Results 61 to 70 of about 4,792 (191)

Enhanced Removal of Protein-Bound Uremic Toxins Using Displacers [PDF]

Clinical Journal of the American Society of Nephrology, 2019
Patients on maintenance dialysis suffer a substantial mortality risk. Traditionally, this increased mortality is attributed to enhanced cardiovascular damage, in itself mostly linked to hastened calcification and vascular stiffness related to inflammation.
Wim, Van Biesen, Sunny, Eloot
openaire   +2 more sources

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy, Darby Alistair C, Alistair C Darby, Allison Heather E, Rooks David J, Rooks, David, Smith, Darren, Paul CM Fogg, Thomson, Nicholas, David J Rooks, Smith Darren L, McCarthy Alan J, McCarthy, Alan, Heather E Allison, Darren L Smith, Allison, Heather, Fogg Paul CM, Nick R Thomson, Fogg, Paul, Darby, Alistair, Thomson Nick R   +20 more
core   +1 more source

Uremic Toxin Clearance and Cardiovascular Toxicities [PDF]

, 2018
Uremic solutes contribute to cardiovascular disease in renal insufficiency. In this review we describe the clearance of selected uremic solutes, which have been associated with cardiovascular disease.
Robert D. Mair, Timothy W. Meyer, Timothy Meyer, Robert D. Mair, Tammy L. Sirich, Timothy W. Meyer, Tammy L. Sirich, Robert Mair, Tammy Sirich   +8 more
core   +1 more source

Probiotic Bifidobacteria Mitigate the Deleterious Effects of para-Cresol in a Drosophila melanogaster Toxicity Model

mSphere, 2022
Renal impairment associated with chronic kidney disease (CKD) causes the buildup of uremic toxins that are deleterious to patient health. Current therapies that manage toxin accumulation in CKD offer an incomplete therapeutic effect against toxins such ...
Gerrit A. Stuivenberg, John A. Chmiel, Polycronis P. Akouris, Jeremy P. Burton, Gregor Reid   +4 more
doaj   +1 more source

Protein-bound uremic toxins impaired mitochondrial dynamics and functions

Oncotarget, 2017
Protein-bound uremic toxins, indoxyl sulfate and p-cresol sulfate, increase oxidative stress and adversely affect chronic kidney disease progression and cardiovascular complications. In this study, we examined whether mitochondria are the target of indoxyl sulfate and p-cresol sulfate intoxication in vivo and in vitro. The kidneys of 10-week-old male B-
Sun, Chiao-Yin, Cheng, Mei-Ling, Pan, Heng-Chih, Lee, Jia-Hung, Lee, Chin-Chan   +4 more
openaire   +3 more sources

Research advances in the mechanisms of indoxyl sulfate and sarcopenia in chronic kidney disease

Linchuang shenzangbing zazhi
Sarcopenia in chronic kidney disease （CKD） occurs mainly in patients with end-stage renal disease （ESRD） on hemodialysis. The potential causes are insufficient nutrition intake, protein and energy consumption, inflammatory cytokines, oxidative stress ...
Shu-yuan Yang, Yan Zhang, Yan-kun Luo
doaj   +1 more source

Comparable Efficacy of Medium Cut-Off Dialysis Plus HA130 Hemoadsorption and Postfilter Hemodiafiltration in Removing Protein-Bound Uremic Toxins

Kidney Medicine
Rationale & Objective: Protein-bound uremic toxins, including indoxyl sulfate and p-cresyl sulfate, are poorly removed by conventional dialysis and contribute to cardiovascular, inflammatory, and neurological complications in end-stage kidney disease.
Gonzalo Ramírez-Guerrero, Cristian Pedreros-Rosales, María José Cáceres, Katherine Saravia, Alejandra Urizar, Armando Rojas, Thiago Reis, Hans Müller-Ortiz, Claudio Ronco   +8 more
doaj   +1 more source

Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome. [PDF]

PLoS ONE, 2017
Intracellular accumulation of protein-bound uremic toxins in the setting of cardiorenal syndrome leads to adverse effects on cardiorenal cellular functions, where cardiac hypertrophy and cardiorenal fibrosis are the hallmarks. In this study, we sought to
Feby Savira, Longxing Cao, Ian Wang, Wendi Yang, Kevin Huang, Yue Hua, Beat M Jucker, Robert N Willette, Li Huang, Henry Krum, Zhiliang Li, Qiang Fu, Bing Hui Wang   +12 more
doaj   +1 more source

Assembly of chemically modified protein nanocages into 3D materials for the adsorption of uremic toxins [PDF]

, 2022
Hemodialysis fails to remove protein-bound uremic toxins that are attributed with high cardiovascular risk. Application of adsorption materials is a viable strategy, but suitable biocompatible adsorbents are still not available. Here, we demonstrate that
Böhler, Hendrik, Orth-Alampour, Setareh, Beck, Tobias, Jankowski, Joachim, Riedner, Maria, Baaten, Constance   +5 more
core   +1 more source

Impact of Indoxyl Sulfate on Progenitor Cell-Related Neovascularization of Peripheral Arterial Disease and Post-Angioplasty Thrombosis of Dialysis Vascular Access

Toxins, 2017
Patients with chronic kidney disease (CKD) have an increased risk of vascular disease, which is associated with considerable health care costs. Vascular disease in CKD differs clinically and pathobiologically from that in patients with normal renal ...
Chih-Cheng Wu, Szu-Chun Hung, Ko-Lin Kuo, Der-Cherng Tarng   +3 more
doaj   +1 more source