Protein-bound uremic toxins: putative modulators of calcineurin inhibitor exposure
Nephrology Dialysis Transplantation, 2022 No abstract ...
Laetitia Koppe, Christophe O Soulage
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Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients. [PDF]
PLoS ONE, 2017 Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points.
Sunny Eloot +7 more
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Scientific Reports, 2021 Protein-bound uremic toxins (Indoxyl sulfate [IS] and p-cresyl sulfate [PCS]) are both associated with cardiovascular (CV) and all-cause mortality in subjects with chronic kidney disease (CKD). Possible mechanisms have not been elucidated.
Ping-Hsun Wu +10 more
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Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients
Toxins, 2021 NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich +10 more
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Review on uremic toxins : classification, concentration, and interindividual variability [PDF]
, 2003 Background. The choice of the correct concentration of potential uremic toxins for in vitro, ex vivo, and in vivo experiments remains a major area of concern; errors at this level might result in incorrect decisions regarding therpeutic correction of ...
Thomas Henle +47 more
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Protein-bound uremic solutes: The forgotten toxins
Kidney International, 2001 The present concept of dialysis focuses mainly on the removal of small water-soluble compounds, and also, the currently applied kinetic parameters of dialysis adequacy are based on the behavior of water-soluble compounds. Nevertheless, many of the currently known biological effects in uremia are attributable to compounds with different physicochemical ...
Vanholder, Raymond +2 more
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Adsorption- and Displacement-Based Approaches for the Removal of Protein-Bound Uremic Toxins
Toxins, 2023 End-stage renal disease (ESRD) patients rely on renal replacement therapies to survive. Hemodialysis (HD), the most widely applied treatment, is responsible for the removal of excess fluid and uremic toxins (UTs) from blood, particularly those with low molecular weight (MW < 500 Da).
Flávia S. C. Rodrigues, Mónica Faria
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Zirconium-Based Metal–Organic Frameworks for the Removal of Protein-Bound Uremic Toxin from Human Serum Albumin [PDF]
, 2019 Uremic toxins often accumulate in patients with compromised kidney function, like those with chronic kidney disease (CKD), leading to major clinical complications including serious illness and death.
Haoyuan Chen +15 more
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Protein-Bound Uremic Toxins: New Insight from Clinical Studies [PDF]
Toxins, 2011 The uremic syndrome is attributed to the progressive retention of a large number of compounds which, under normal conditions, are excreted by healthy kidneys. The compounds are called uremic toxins when they interact negatively with biological functions.
Sophie Liabeuf +2 more
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Effects of uremic toxin p-cresol on oxidative stress in human coronary artery endothelial cells
Di-san junyi daxue xuebao, 2021 Objective To investigate the effects of uremic toxin p-cresol (PC) on the oxidative stress of human coronary artery endothelial cells (HCAECs). Methods HCAECs were cultured in vitro, and treated with different concentrations of free PC alone or combined ...
LI Li, LI Jing, YUAN Fahuan, LI Xiaoli
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