Results 71 to 80 of about 4,792 (191)

Extracellular Vesicles and Their Relationship with the Heart–Kidney Axis, Uremia and Peritoneal Dialysis

Toxins, 2021
Cardiorenal syndrome (CRS) is described as primary dysfunction in the heart culminating in renal injury or vice versa. CRS can be classified into five groups, and uremic toxin (UT) accumulation is observed in all types of CRS. Protein-bound uremic toxin (
Carolina Amaral Bueno Azevedo, Regiane Stafim da Cunha, Carolina Victoria Cruz Junho, Jessica Verônica da Silva, Andréa N. Moreno-Amaral, Thyago Proença de Moraes, Marcela Sorelli Carneiro-Ramos, Andréa Emilia Marques Stinghen   +7 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Is 3-Carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) a Clinically Relevant Uremic Toxin in Haemodialysis Patients? [PDF]

, 2018
International audience3-Carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) is a metabolite of furan fatty acid and a marker of fish oil intake. CMPF is described as a protein-bound uremic toxin and interacts with free oxygen radicals, which can induce ...
Szelag, Jean Christophe, Denis Fouque, Christophe Soulage, Jean Christophe Szelag, Luce, Mathilde, Bouchara, Anais, Laville, Maurice, Samuel Granjon, Szelag, Jean, Fouque, Denis, Koppe-Guichard, Laetitia, Pastural, Myriam, Granjon, Samuel, Arkouche, Walid, Mathilde Luce, Soulage, Christophe, Koppe, Laetitia, Anais Bouchara, Christophe O. Soulage, Laetitia Koppe, Maurice Laville, Jean Szelag, Walid Arkouche, Myriam Pastural   +23 more
core   +1 more source

Uremic Toxins and Hemodiafiltration: From Molecular Mechanisms to Clinical Outcomes

Toxins
Uremic syndrome results from the accumulation of biologically active solutes that contribute to inflammation, oxidative stress, endothelial dysfunction, cardiovascular disease, anemia, CKD–mineral and bone disorder, and protein-energy wasting in patients
Stefano Stuard, Charles Hugh-Jones, Dinesh Chatoth, Michael Anger, Alfred Gagel, Bernard Canaud   +5 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Protein-Bound Uremic Toxins Stimulate Crosstalk between Leukocytes and Vessel Wall [PDF]

Journal of the American Society of Nephrology, 2013
Leukocyte activation and endothelial damage both contribute to cardiovascular disease, a major cause of morbidity and mortality in CKD. Experimental in vitro data link several protein-bound uremic retention solutes to the modulation of inflammatory stimuli, including endothelium and leukocyte responses and cardiovascular damage, corroborating ...
Pletinck, A., Glorieux, G., Schepers, E., Cohen, G., Gondouin, B., Landschoot, M. Van, Eloot, S., Rops, L.W.M.M., Voorde, J. van de, Vriese, A. de, Vlag, J. van der, Brunet, P., Biesen, W. Van, Vanholder, R.   +13 more
openaire   +3 more sources

Intimin, tir, and shiga toxin 1 do not influence enteropathogenic responses to shiga toxin-producing Escherichia coli in bovine ligated intestinal loops [PDF]

, 2002
Shiga toxin-producing Escherchia coli (STEC) comprises a group of attaching and effacing (A/E) enteric pathogens of animals and humans. Natural and experimental infection of calves with STEC may result in acute enteritis or subclinical infection ...
Campbell, June, June Campbell, Timothy S. Wallis, Phillips, A D, Oswald, Eric, Campbell, J, Olivier Marchès, Phillips, Alan D., Wallis, Timothy S., Stevens, M P, Veronika Huter, Gad Frankel, Huter, V, Wallis, T S, Mark P. Stevens, Alan D. Phillips, Marchès, Olivier, Huter, Veronika, Marches, O, Oswald, E, Frankel, Gad, Stevens, Mark P., Frankel, G, Eric Oswald   +23 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal disease. [PDF]

PLoS ONE, 2015
Chronic renal failure is characterized by progressive renal scarring and accelerated arteriosclerotic cardiovascular disease despite what is considered to be adequate hemodialysis or peritoneal dialysis. In rodents with reduced renal mass, renal scarring
Sachin Jhawar, Prabhjot Singh, Daniel Torres, Francisco Ramirez-Valle, Hania Kassem, Trina Banerjee, Igor Dolgalev, Adriana Heguy, Jiri Zavadil, Jerome Lowenstein   +9 more
doaj   +1 more source