Results 91 to 100 of about 7,413 (211)

Efficient selective removal of uremic toxin precursor by olefin-linked covalent organic frameworks for nephropathy treatment

Nature Communications, 2023
Indoxyl sulfate is a protein-bound uremic toxin synthesized from indole that cannot be efficiently removed by the hemodialysis method and thus becomes a key risk factor for the progression of chronic kidney disease.
Jinxia Wei, Rui Li, Penghui Zhang, Haiqun Jin, Zhenjie Zhang, Yubo Li, Yao Chen   +6 more
doaj   +1 more source

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB [PDF]

, 2013
BACKGROUND: Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD) patients, accelerating the progression of CKD.
Dilinaer Bolati, Fuyuhiko Nishijima, Hidehisa Shimizu, Maimaiti Yisireyili, Toshimitsu Niwa   +4 more
core   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Vasculopathy in the setting of cardiorenal syndrome: roles of protein-bound uremic toxins [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2017
Chronic kidney disease (CKD) often leads to and accelerates the progression of cardiovascular disease (CVD), while CVD also causes kidney dysfunction. This bidirectional interaction leads to the development of a complex syndrome known as cardiorenal syndrome (CRS). CRS not only involves both the heart and the kidney but also the vascular system through
Jingbin, Guo, Lu, Lu, Yue, Hua, Kevin, Huang, Ian, Wang, Li, Huang, Qiang, Fu, Aihua, Chen, Paul, Chan, Huimin, Fan, Zhong-Min, Liu, Bing Hui, Wang   +11 more
openaire   +2 more sources

Prognostic value of contrast‐enhanced ultrasound in dogs with acute renal injury treated with haemodialysis

Veterinary Record, Volume 196, Issue 6, 15/22 March 2025.
Abstract Background It is clinically relevant to predict outcomes in dogs with acute kidney injury (AKI) treated with haemodialysis. The aim of this study was to evaluate the prognostic value of contrast‐enhanced ultrasound (CEUS) and its role in discriminating between AKI and acute impairment associated with chronic kidney disease (AKI/CKD).
Caterina Puccinelli, Ilaria Lippi, Tina Pelligra, Simonetta Citi   +3 more
wiley   +1 more source

Primary Human Derived Blood Outgrowth Endothelial Cells: An Appropriate In Vitro Model to Study Shiga Toxin Mediated Damage of Endothelial Cells

Toxins, 2020
Hemolytic uremic syndrome (HUS) is a rare disease primarily characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Endothelial damage is the hallmark of the pathogenesis of HUS with an infection with the Shiga toxin (Stx) producing
Wouter J. C. Feitz, Nicole C. A. J. van de Kar, Ian Cheong, Thea J. A. M. van der Velden, Carolina G. Ortiz-Sandoval, Dorothea Orth-Höller, Lambert P. J. W. van den Heuvel, Christoph Licht   +7 more
doaj   +1 more source

Interaction of Human Serum Albumin with short Polyelectrolytes: A study by Calorimetry and Computer Simulation

, 2015
We present a comprehensive study of the interaction of human serum albumin (HSA) with poly(acrylic acid) (PAA; number average degree of polymerization: 25) in aqueous solution. The interaction of HSA with PAA is studied in dilute solution as the function
Ballauff, Matthias, Dzubiella, Joachim, Jankowski, Joachim, van der Giet, Markus, Xu, Xiao, Yigit, Cemil, Yu, Shun, Zidek, Walter   +7 more
core   +1 more source

An In Vitro System for Studying Toxin Transport Across Hemodialysis Membranes

Artificial Organs, EarlyView.
Development of an in vitro hemodialysis (HD) system based on mini dialyzers for evaluating hemodialysis membranes under physiologically relevant conditions. ABSTRACT Background Healthy kidneys regulate acid–base balance and electrolytes, produce hormones, and clear excess fluids and uremic toxins.
M. Torrents‐Yeste, D. Ramada, O. E. M. ter Beek, F. Pel, J. de Vries, B. H. Lentferink, K. G. F. Gerritsen, D. Stamatialis   +7 more
wiley   +1 more source

Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient

Case Reports in Nephrology, 2016
Uric acid accumulates in renal failure and is thought to be a uremic toxin—that is, higher levels of uric acid are more damaging to the kidneys. Urate crystals can precipitate in the kidney tubules, cause urate stones, and promote inflammatory changes in
Lynda Ann Frassetto, Suzanne Gibson
doaj   +1 more source

Differences in Dialysis Efficacy Have Limited Effects on Protein-Bound Uremic Toxins Plasma Levels over Time

Toxins, 2019
The protein-bound uremic toxins para-cresyl sulfate (pCS) and indoxyl sulfate (IS) are associated with cardiovascular disease in chronic renal failure, but the effect of different dialysis procedures on their plasma levels over time is poorly studied ...
Detlef H. Krieter, Simon Kerwagen, Marieke Rüth, Horst-Dieter Lemke, Christoph Wanner   +4 more
doaj   +1 more source