Results 91 to 100 of about 4,792 (191)

From Physicochemical Classification to Multidimensional Insights: A Comprehensive Review of Uremic Toxin Research. [PDF]

Toxins (Basel)
Chronic kidney disease (CKD) is a global health burden, with uremic toxins (UTs) playing a central role in its pathophysiology. In this review, we systematically examined the evolution of UT classification from the 2003 European Uremic Toxin Work Group ...
Cozzolino M, Magagnoli L, Ciceri P.
europepmc   +3 more sources

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Protein-bound uremic toxin kinetics modeling for a new dialysis device [PDF]

, 2020
Thesis (Master's)--University of Washington, 2020Addition to the conventional hemodialysis, a protein-bound uremic toxins process device is designed. To better understand the mechanism of this novel device, we build a fixed-bed adsorbent column model to ...
Liu, Kailei
core   +1 more source

Prognostic value of contrast‐enhanced ultrasound in dogs with acute renal injury treated with haemodialysis

Veterinary Record, Volume 196, Issue 6, 15/22 March 2025.
Abstract Background It is clinically relevant to predict outcomes in dogs with acute kidney injury (AKI) treated with haemodialysis. The aim of this study was to evaluate the prognostic value of contrast‐enhanced ultrasound (CEUS) and its role in discriminating between AKI and acute impairment associated with chronic kidney disease (AKI/CKD).
Caterina Puccinelli, Ilaria Lippi, Tina Pelligra, Simonetta Citi   +3 more
wiley   +1 more source

Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor [PDF]

Clinical Journal of the American Society of Nephrology, 2019
Current hemodialysis techniques fail to efficiently remove the protein-bound uremic toxins p-cresyl sulfate and indoxyl sulfate due to their high degree of albumin binding. Ibuprofen, which shares the same primary albumin binding site with p-cresyl sulfate and indoxyl sulfate, can be infused during hemodialysis to displace these toxins, thereby ...
Magdalena, Madero, Karla B, Cano, Israel, Campos, Xia, Tao, Vaibhav, Maheshwari, Jillian, Brown, Beatriz, Cornejo, Garry, Handelman, Stephan, Thijssen, Peter, Kotanko   +9 more
openaire   +2 more sources

Immunosenescence and Immune Exhaustion Are Associated with Levels of Protein-Bound Uremic Toxins in Patients on Hemodialysis

Biomedicines, 2023
Background: The accumulation of protein-bound uremic toxins (PBUTs) in chronic kidney disease may affect patients’ immune status. The aim of the study was to evaluate their potential impacts on lymphocyte alterations in patients on hemodialysis (HD).
Theodoros Tourountzis, Georgios Lioulios, Steven Van Laecke, Evdoxia Ginikopoulou, Vasiliki Nikolaidou, Eleni Moysidou, Stamatia Stai, Michalis Christodoulou, Asimina Fylaktou, Griet Glorieux, Maria Stangou   +10 more
openaire   +4 more sources

Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease

VIEW, EarlyView.
This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin, Lijie Ma, Yuqing Yuan, Kaiyi Zhu, Zhaohui Tong, Qianmei Sun   +5 more
wiley   +1 more source

Is Fluorescence Valid to Monitor Removal of Protein Bound Uremic Solutes in Dialysis? [PDF]

PLoS ONE, 2016
The aim of this study was to evaluate the contribution and removal dynamics of the main fluorophores during dialysis by analyzing the spent dialysate samples to prove the hypothesis whether the fluorescence of spent dialysate can be utilized for ...
Jürgen Arund, Merike Luman, Fredrik Uhlin, Risto Tanner, Ivo Fridolin   +4 more
doaj   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Development of clinical methods for increased removal of protein-bound uremic toxins in the context of an extracorporeal therapy. [PDF]

, 2014
Die extrakorporale Nierenersatztherapie ist gegenwärtig das Verfahren der Wahl zur Behandlung von chronischen Nierenversagen, sofern kein Spenderorgan zu Verfügung steht und somit eine Nierentransplantation nicht möglich ist. Rezente Nierenersatztherapie-
Böhringer, Falko
core   +1 more source