Results 101 to 110 of about 4,792 (191)

p-Cresyl Sulfate

Toxins, 2017
If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Tessa Gryp, Raymond Vanholder, Mario Vaneechoutte, Griet Glorieux   +3 more
doaj   +1 more source

Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients

Hemodialysis International, EarlyView.
ABSTRACT Introduction Tenapanor, a minimally absorbed intestinal NHE3 inhibitor approved for hyperphosphatemia in dialysis, lowers phosphate and reduces intestinal sodium absorption. Its sodium–water signal may have implications beyond phosphate but remains poorly separated from diarrhea‐mediated losses and dialysis prescription artifacts. Methods This
Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior   +8 more
wiley   +1 more source

Uremic Toxin Concentrations are Related to Residual Kidney Function in the Pediatric Hemodialysis Population [PDF]

, 2019
Protein-bound uremic toxins (PBUTs) play a role in the multisystem disease that children on hemodialysis (HD) are facing, but little is known about their levels and protein binding (%PB).
Stefanidis, Constantinos J.,, Griet Glorieux, Stefanidis, Constantinos J., Azukaitis, K., Sanne Roels, Collard, Laure, Wim Van Biesen, Vande Walle, Johan, Shroff, Rukshana, Claus Peter Schmitt, Roels, Sandrine, Askiti, Varvara,, Koen Van Hoeck, Fabio Paglialonga, Paglialonga, Fabio,, Brankica Spasojevic, Paglialonga, Fabio, Stefanidis, Constantinos J, Eloot, Sunny, Spasojevic, B., Van Dyck, Maria, Godefroid, Nathalie, Stefanidis, C.J., Obrycki, Lukasz,, Karolis Azukaitis, Van Dyck, M., Shroff, R., Evelien Snauwaert, Johan Vande Walle, Aysun Bayazit, Laure Collard, Fischbach, Michel, Van Hoeck, Koen, Constantinos J. Stefanidis, Snauwaert, Evelien, Litwin, M., Canpolat, Nur,, Mieczyslaw Litwin, Schmitt, C.P., Sunny Eloot, Bayazit, A., Askiti, Varvara, Godefroid, Nathalie,, Vanholder, Raymond,, Bruno Ranchin, Holvoet, Els, Constantinos J. Stefanidis, Van Biesen, Wim,, Litwin, Mieczyslaw, Walle, Johan Vande,, Schmitt, Claus Peter,, Samaille, Charlotte, Snauwaert, Evelien,, Bayazit, Aysun,, Samaille, Charlotte,, Litwin, Mieczyaw, Raes, Ann, El Amouri, Amina, Varvara Askiti, Ranchin, B., Nur Canpolat, Azukaitis, Karolis, Ann Raes, Van Hoeck, K., Litwin, Mieczyslaw,, Schaefer, F., Roels, Sanne, Ranchin, Bruno, Askiti, V., Glorieux, Griet, Obrycki, L., Saoussen Krid, Franz Schaefer, Vanholder, Raymond, Roels, Sanne,, Bayazit, Aysun, Lukasz Obrycki, Holvoet, Els,, Van Biesen, Wim, Canpolat, Nur, Krid, Saoussen, Van de Walle, J., Collard, Laure,, Ažukaitis, Karolis,, Eloot, S., Canpolat, N., Samaille, C., Maria Van Dyck, Schaefer, Franz, Charlotte Samaille, Shroff, Rukshana,, Raymond Vanholder, Spasojevic, Brankica, Krid, S., Obrycki, Lukasz, Michel Fischbach, Raes, Ann,, Fischbach, Michel,, Nathalie Godefroid, Schaefer, Franz,, Fischbach, M., Godefroi, N., Schmitt, Claus Peter, Van Dyck, Maria,, Van Hoeck, Koen,, Glorieux, Griet,, Krid, Saoussen,, Els Holvoet, Claus Peter Schmitt, Paglialonga, F., Collard, L., Ranchin, Bruno,, Rukshana Shroff, Spasojevic, Brankica,, Eloot, Sunny,   +114 more
core   +1 more source

Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2–KEAP1–CUL3 Interactions in Chronic Kidney Disease

Antioxidants, 2020
Chronic kidney disease (CKD) is characterized by the accumulation of protein-bound uremic toxins (PBUTs), which play a pathophysiological role in renal fibrosis (a common pathological process resulting in CKD progression).
Bowen Sun, Xifan Wang, Xiaoxue Liu, Longjiao Wang, Fazheng Ren, Xiaoyu Wang, Xiaojing Leng   +6 more
doaj   +1 more source

Efficient selective removal of uremic toxin precursor by olefin-linked covalent organic frameworks for nephropathy treatment

Nature Communications, 2023
Indoxyl sulfate is a protein-bound uremic toxin synthesized from indole that cannot be efficiently removed by the hemodialysis method and thus becomes a key risk factor for the progression of chronic kidney disease.
Jinxia Wei, Rui Li, Penghui Zhang, Haiqun Jin, Zhenjie Zhang, Yubo Li, Yao Chen   +6 more
doaj   +1 more source

Infection with the Neorickettsial Organism Stellantchasmus falcatus Agent in an Arctic Fox (Vulpes lagopus)

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 1‐year‐old female‐intact arctic fox (Vulpes lagopus) presented for diarrhea, lethargy, severe thrombocytopenia, and hyperbilirubinemia. Blood film evaluation revealed intracytoplasmic coccoid bacteria within moderate numbers of leukocytes consistent with infection by a rickettsial organism.
Jeremy P. Bessett, Alexis G. Davidson, Alyssa M. Scagnelli, Kristen R. Friedrichs   +3 more
wiley   +1 more source

From bench to the hemodialysis clinic: protein-bound uremic toxins modulate NF-\kappaB/Nrf2 expression [PDF]

, 2017
International audiencePURPOSE: Uremic toxins produced by gut microbiota (indoxyl sulfate-IS, p-cresyl sulfate-p-CS, and indole-3-acetic acid-IAA) accumulate in hemodialysis (HD) patients and exhibit potent inflammatory effects.
Cardozo, Ludmila F. M. F., Denis Fouque, Mafra, Denise, Nakao, Lia S., Denise Mafra, Milena B. Stockler-Pinto, Borges, Natália A., Ludmila F. M. F. Cardozo, Fouque, Denis, Dolenga, Carla J., Natália A. Borges, Roberto Pecoits-Filho, Soulage, Christophe, Pecoits-Filho, Roberto, Christophe O. Soulage, Stockler-Pinto, Milena B., Lia S. Nakao, Carla J. Dolenga   +17 more
core   +1 more source

Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient

Case Reports in Nephrology, 2016
Uric acid accumulates in renal failure and is thought to be a uremic toxin—that is, higher levels of uric acid are more damaging to the kidneys. Urate crystals can precipitate in the kidney tubules, cause urate stones, and promote inflammatory changes in
Lynda Ann Frassetto, Suzanne Gibson
doaj   +1 more source

Sepsis in Dogs and Cats—Consensus Definition and Clinical Criteria

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Sepsis is the clinical syndrome that results from the host response to severe or widespread infection and is a frequent cause of death in veterinary critical care settings. Rapid diagnosis aids early treatment initiation, and hence, how sepsis is defined and identified clinically has implications for patient outcomes.
Robert Goggs, Stefano Cortellini, Amy E. DeClue, Massimo Giunti, Kate Hopper, Julie M. Menard, Rodrigo C. Rabelo, Elizabeth A. Rozanski, Claire R. Sharp, Deborah C. Silverstein, Virginia Sinnott‐Stutzman, Giacomo Stanzani, John Bourgeois, Erik Fausak   +13 more
wiley   +1 more source

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, Volume 30, Issue 4, Page 544-550, August 2026.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source