Results 121 to 130 of about 4,792 (191)

Treatment of Restless Legs Syndrome in Dialysis Patients

Seminars in Dialysis, EarlyView.
Kenji Sakurai, Yoshitaka Kurihara, Hiromi Hosoya, Fumi Yamouchi, Takeshi Saito   +4 more
wiley   +1 more source

Food Safety and Nutritional Aspects of Plant‐Based Dairy and Meat Alternatives: A Review

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Plant‐based dairy and meat alternatives (PBDA and PBMA) offer sustainability benefits but also introduce chemical and microbiological hazards to the diet. Key concerns include emerging mycotoxins, heavy metals, process contaminants, and heat‐resistant spore‐forming bacteria.
Elina Sohlberg, Petra Pasonen, Hanna‐Leena Alakomi, Johanna Suomi   +3 more
wiley   +1 more source

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

Salvianolic Acid B Upregulates miR‐744‐5p Expression in Peripheral Blood Mononuclear Cell–Derived Extracellular Vesicles to Alleviate Uremic Cardiomyopathy

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
Uremic cardiomyopathy (UCM) is a life‐threatening complication of uremia. We find that extracellular vesicle (EV)‐miR‐744‐5p mediates peripheral blood mononuclear cell (PBMC)‐cardiomyocyte communication in UCM. Salvianolic acid B treats UCM by modulating EV‐miR‐744‐5p expression.
Ziran Wang, Jiaojiao Hao, Yaxi Shang, Wenli Ma, Nan Wang, Weidong Wang, Qingzhu Tang, Xiangning Du, Fan Yang, Biaojie Qin, Shuni Chen, Kun Xiao, Longkai Li, Xianan Guo, Xin Qi, Shuang Meng, Huiyi Song, Hongli Lin   +17 more
wiley   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic cornerstone of model‐informed drug development (MIDD), providing evidence for regulatory decisions. PBPK models integrate physiological and pharmacological data and have been applied across a plethora of contexts of use, including assessing drug–drug interactions (DDIs ...
Marylore Chenel, Andre Dallmann, Ibrahim Ince, Michaela Meyer, Jan‐Frederik Schlender, Donato Teutonico, Erik Sjögren   +6 more
wiley   +1 more source

Bioengineered kidney tubules efficiently excrete uremic toxins [PDF]

, 2016
The development of a biotechnological platform for the removal of waste products (e.g. uremic toxins), often bound to proteins in plasma, is a prerequisite to improve current treatment modalities for patients suffering from end stage renal disease (ESRD).
Masereeuw, R, Kreuser, U M, Wetzels, J.F.M., Heuvel, L.P.W.J. van den, Boltje, T J, Mensink, R A, Hoenderop, J.G., Broek, P.H. van den, van den Heuvel, L P, Stamatialis, D., Jansen, J., Sub Experimental pharmacology, Wilmer, M J, Kreuser, U.M., Peters, J.G., Wetzels, J.F., Wilmer, M.J., Peters, J G, Stamatialis, D, Masereeuw, R., van den Heuvel, L.P., van den Broek, P H, Boltje, T.J., van den Broek, P.H., Wetzels, J F, Pharmacology, Mensink, R.A., Hoenderop, J G, Jansen, J, Fedecostante, M, Fedecostante, M.   +30 more
core   +1 more source

An In Vitro System for Studying Toxin Transport Across Hemodialysis Membranes

Artificial Organs, Volume 50, Issue 7, Page 988-1006, July 2026.
Development of an in vitro hemodialysis (HD) system based on mini dialyzers for evaluating hemodialysis membranes under physiologically relevant conditions. ABSTRACT Background Healthy kidneys regulate acid–base balance and electrolytes, produce hormones, and clear excess fluids and uremic toxins.
M. Torrents‐Yeste, D. Ramada, O. E. M. ter Beek, F. Pel, J. de Vries, B. H. Lentferink, K. G. F. Gerritsen, D. Stamatialis   +7 more
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

The kidney and uremic toxin removal: glomerulus or tubule? [PDF]

, 2014
Item does not contain fulltextChronic kidney disease (CKD) is a condition that affects approximately 10% of the adult population in developed countries.
Abe, T., Masereeuw, R., Jhawar, S., Toyohara, T., Mutsaers, H.A.M., Lowenstein, J., Sweet, D.H.   +6 more
core   +1 more source