Toxins, 2019 Protein-bound uremic toxins (PBUTs) play a role in the multisystem disease that children on hemodialysis (HD) are facing, but little is known about their levels and protein binding (%PB).
Evelien Snauwaert +28 more
doaj +1 more source
Aryl hydrocarbon receptor activation mediates kidney disease and renal cell carcinoma. [PDF]
, 2019 The aryl hydrocarbon receptor (AhR) is a well-known ligand-activated cytoplasmic transcription factor that contributes to cellular responses against environmental toxins and carcinogens.
Chen, Lin +8 more
core +1 more source
The Choice of Anti-Inflammatory Influences the Elimination of Protein-Bound Uremic Toxins
ToxinsPain is a frequent and disturbing symptom among hemodialysis patients. Protein-bound uremic toxins (PBUTs) are related to cardiovascular and overall mortality, and they are difficult to remove with current hemodialysis treatments. The PBUT displacers, such as furosemide, tryptophan, or ibuprofen, may be promising new strategies for improving their ...
Víctor Joaquín Escudero-Saiz +10 more
openaire +3 more sources
Frontiers in EndocrinologyCardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, and cardiovascular diseases, leading to multi-organ dysfunction and a higher incidence of cardiovascular endpoints.
Shihan Zhang +6 more
openaire +3 more sources
A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. [PDF]
, 2019 Genes central to drug absorption, distribution, metabolism and elimination (ADME) also regulate numerous endogenous molecules. The Remote Sensing and Signaling Hypothesis argues that an ADME gene-centered network-including SLC and ABC "drug" transporters,
Bush, Kevin T +2 more
core +1 more source
Precision Hemodialysis Using Sorbents to Remove Protein-Bound Uremic Toxins
Kidney360, 2023 openaire +2 more sources
The Arrhythmogenic Effect of Protein-Bound Uremic Toxin p-Cresylsulfate: An In Vitro Study. [PDF]
Acta Cardiol Sin, 2019 Tsai IT +7 more
europepmc +1 more source
Unambiguous Characterization of p-Cresyl Sulfate, a Protein-Bound Uremic Toxin, as Biomarker of Heart and Kidney Disease. [PDF]
Molecules, 2019 Paroni R +5 more
europepmc +1 more source
A plea for more uremic toxin research in children with chronic kidney disease [PDF]
, 2018 Eloot, Sunny +6 more
core +2 more sources
FP464COMPARISON OF EXTRACORPOREAL THERAPIES FOR PROTEIN-BOUND UREMIC TOXINS REMOVAL [PDF]
Nephrology Dialysis Transplantation, 2018 Vaibhav Maheshwari +5 more
openaire +1 more source