Gut-Derived Protein-Bound Uremic Toxins [PDF]
Toxins, 2020 Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of the fastest growing global causes of mortality. When glomerular filtration rate begins to fall, uremic toxins accumulate in the serum and significantly increase ...
Amanda L. Graboski, Matthew R. Redinbo
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Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders [PDF]
Frontiers in EndocrinologyCardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, and cardiovascular diseases, leading to multi-organ ...
Shihan Zhang +6 more
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Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis [PDF]
Biomedicines, 2023 Chronic kidney disease (CKD) is a progressive condition of kidney dysfunction due to diverse causes of injury. In healthy kidneys, protein-bound uremic toxins (PBUTs) are cleared from the systemic circulation by proximal tubule cells through the ...
Yi Yang +2 more
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Adsorption- and Displacement-Based Approaches for the Removal of Protein-Bound Uremic Toxins [PDF]
Toxins, 2023 End-stage renal disease (ESRD) patients rely on renal replacement therapies to survive. Hemodialysis (HD), the most widely applied treatment, is responsible for the removal of excess fluid and uremic toxins (UTs) from blood, particularly those with low ...
Flávia S. C. Rodrigues, Mónica Faria
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The Medium Cut-Off Membrane Does Not Lower Protein-Bound Uremic Toxins [PDF]
Toxins, 2022 The accumulation of protein-bound uremic toxins (PBUT) is associated with increased cardiovascular outcomes in patients on dialysis. However, the efficacy of PBUT removal for a medium-cutoff (MCO) membrane has not been clarified.
Yang Gyun Kim +8 more
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The Choice of Anti-Inflammatory Influences the Elimination of Protein-Bound Uremic Toxins [PDF]
ToxinsPain is a frequent and disturbing symptom among hemodialysis patients. Protein-bound uremic toxins (PBUTs) are related to cardiovascular and overall mortality, and they are difficult to remove with current hemodialysis treatments.
Víctor Joaquín Escudero-Saiz +10 more
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Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes [PDF]
Toxins, 2019 To better understand the kinetics of protein-bound uremic toxins (PBUTs) during hemodialysis (HD), we investigated the distribution of hippuric acid (HA), indole-3-acetic acid (IAA), indoxyl sulfate (IS), and p-cresyl sulfate (pCS) in erythrocytes of HD ...
Olivier Deltombe +5 more
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Effect of Low Protein Diet Supplemented with Ketoanalogs on Endothelial Function and Protein-Bound Uremic Toxins in Patients with Chronic Kidney Disease [PDF]
Biomedicines, 2023 Studies have demonstrated that a low-protein diet supplemented with ketoanalogs (KAs) could significantly retard progression of renal function in patients with chronic kidney disease (CKD) stages 3–5.
George Chang +4 more
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Strategies for Removal of Protein-Bound Uremic Toxins in Hemodialysis [PDF]
ToxinsThe removal of protein-bound uremic toxins (PBUTs) from the blood of kidney failure patients with conventional dialysis is limited. However, as their harmful effects and association with morbidity and mortality in dialysis patients are increasingly ...
Joost C. de Vries +9 more
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Immunosenescence and Immune Exhaustion Are Associated with Levels of Protein-Bound Uremic Toxins in Patients on Hemodialysis [PDF]
Biomedicines, 2023 Background: The accumulation of protein-bound uremic toxins (PBUTs) in chronic kidney disease may affect patients’ immune status. The aim of the study was to evaluate their potential impacts on lymphocyte alterations in patients on hemodialysis (HD ...
Theodoros Tourountzis +10 more
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