Gut-Derived Protein-Bound Uremic Toxins [PDF]
Toxins, 2020 Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of the fastest growing global causes of mortality. When glomerular filtration rate begins to fall, uremic toxins accumulate in the serum and significantly increase ...
Amanda L. Graboski, Matthew R. Redinbo
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Adsorption- and Displacement-Based Approaches for the Removal of Protein-Bound Uremic Toxins [PDF]
Toxins, 2023 End-stage renal disease (ESRD) patients rely on renal replacement therapies to survive. Hemodialysis (HD), the most widely applied treatment, is responsible for the removal of excess fluid and uremic toxins (UTs) from blood, particularly those with low ...
Flávia S. C. Rodrigues, Mónica Faria
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Protein-Bound Uremic Toxins: New Insight from Clinical Studies [PDF]
Toxins, 2011 The uremic syndrome is attributed to the progressive retention of a large number of compounds which, under normal conditions, are excreted by healthy kidneys. The compounds are called uremic toxins when they interact negatively with biological functions.
Ziad A. Massy +2 more
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The Medium Cut-Off Membrane Does Not Lower Protein-Bound Uremic Toxins [PDF]
Toxins, 2022 The accumulation of protein-bound uremic toxins (PBUT) is associated with increased cardiovascular outcomes in patients on dialysis. However, the efficacy of PBUT removal for a medium-cutoff (MCO) membrane has not been clarified.
Yang Gyun Kim +8 more
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Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis [PDF]
Biomedicines, 2023 Chronic kidney disease (CKD) is a progressive condition of kidney dysfunction due to diverse causes of injury. In healthy kidneys, protein-bound uremic toxins (PBUTs) are cleared from the systemic circulation by proximal tubule cells through the ...
Yi Yang +2 more
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Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders [PDF]
Frontiers in EndocrinologyCardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, and cardiovascular diseases, leading to multi-organ ...
Shihan Zhang +6 more
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Toxins, 2014 Chronic kidney disease (CKD) has been considered a major risk factor for cardiovascular diseases. Although great advances have recently been made in the pathophysiology and treatment of cardiovascular diseases, CKD remains a major global health problem ...
Shunsuke Ito, Masayuki Yoshida
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Strategies for Removal of Protein-Bound Uremic Toxins in Hemodialysis [PDF]
ToxinsThe removal of protein-bound uremic toxins (PBUTs) from the blood of kidney failure patients with conventional dialysis is limited. However, as their harmful effects and association with morbidity and mortality in dialysis patients are increasingly ...
Joost C. de Vries +9 more
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Comparable Efficacy of Medium Cut-Off Dialysis Plus HA130 Hemoadsorption and Postfilter Hemodiafiltration in Removing Protein-Bound Uremic Toxins [PDF]
Kidney MedicineRationale & Objective: Protein-bound uremic toxins, including indoxyl sulfate and p-cresyl sulfate, are poorly removed by conventional dialysis and contribute to cardiovascular, inflammatory, and neurological complications in end-stage kidney disease.
Gonzalo Ramírez-Guerrero +8 more
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Effect of Low Protein Diet Supplemented with Ketoanalogs on Endothelial Function and Protein-Bound Uremic Toxins in Patients with Chronic Kidney Disease [PDF]
Biomedicines, 2023 Studies have demonstrated that a low-protein diet supplemented with ketoanalogs (KAs) could significantly retard progression of renal function in patients with chronic kidney disease (CKD) stages 3–5.
George Chang +4 more
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