Results 21 to 30 of about 15,339 (215)

Protein-Bound Uremic Toxins and Inflammation Process in Hemodialysis Patients: Is There a Role for Adsorption Hemodiafiltration?

Blood Purif, 2023
Introduction: Despite major advances in the field of dialysis, there are still some unmet needs such as reducing inflammation through adequate depuration.
Fabbrini P, Vergani D, Malinverno A, Pieruzzi F, Marengo M, Merlotti G, Medana C, Quercia AD, Cantaluppi V.   +8 more
europepmc   +2 more sources

Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Modulating Protein-Bound Uremic Toxins and Gut Microbiota in Predialysis CKD Patients: Matched Case-Control Study. [PDF]

Kidney360
Visual ...
Hsu CK, Chang LC, Chen YT, Chen CY, Hsu HR, Bai S, Lee CC, Lee CC, Jangir H, Sun CY, Su SC, Wu IW.   +11 more
europepmc   +2 more sources

Pruritus and protein-bound uremic toxins in patients undergoing hemodialysis: a cross-sectional study. [PDF]

Clin Kidney J
Background Patients undergoing hemodialysis frequently experience pruritus; its severity is associated with poor quality of life and mortality. Recent progress in hemodialysis treatment has improved the removal of small- and middle-molecular-weight ...
Yamamoto S, Tanaka T, Omori K, Ei I, Kikuchi K, Konagai A, Goto S, Kitamura N, Narita I.   +8 more
europepmc   +2 more sources

The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury. [PDF]

Toxins (Basel), 2022
Acute kidney injury (AKI) is a frequent disease encountered in the hospital, with a higher incidence in intensive care units. Despite progress in renal replacement therapy, AKI is still associated with early and late complications, especially ...
Caillard P, Bennis Y, Six I, Bodeau S, Kamel S, Choukroun G, Maizel J, Titeca-Beauport D.   +7 more
europepmc   +2 more sources

A Novel Strategy for Enhanced Sequestration of Protein-Bound Uremic Toxins Using Smart Hybrid Membranes. [PDF]

J Funct Biomater, 2023
Currently available hemodialysis (HD) membranes are unable to safely remove protein-bound uremic toxins (PBUTs), especially those bonded to human serum albumin (HSA).
Lopes M, Pires RF, Faria M, Bonifácio VDB.   +3 more
europepmc   +2 more sources

Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney disease.

Kidney International, 2020
Chronic kidney disease (CKD) is characterized by accumulation of protein-bound uremic toxins such as p-cresyl sulfate, p-cresyl glucuronide, indoxyl sulfate and indole-3-acetic acid, which originate in the gut.
T. Gryp, K. De Paepe, R. Vanholder, F. Kerckhof, W. van Biesen, T. van de Wiele, F. Verbeke, M. Speeckaert, M. Joossens, M. Couttenye, Mario Vaneechoutte, G. Glorieux   +11 more
semanticscholar   +3 more sources

Gut Microbiota and Their Derived Metabolites, a Search for Potential Targets to Limit Accumulation of Protein-Bound Uremic Toxins in Chronic Kidney Disease. [PDF]

Toxins (Basel), 2021
Chronic kidney disease (CKD) is characterized by gut dysbiosis with a decrease in short-chain fatty acid (SCFA)-producing bacteria. Levels of protein-bound uremic toxins (PBUTs) and post-translational modifications (PTMs) of albumin increase with CKD ...
Steenbeke M, Valkenburg S, Valkenburg S, Gryp T, Van Biesen W, Delanghe JR, Speeckaert MM, Glorieux G.   +7 more
europepmc   +2 more sources

Protein-Bound Uremic Toxins: New Culprits of Cardiovascular Events in Chronic Kidney Disease Patients

Toxins, 2014
Chronic kidney disease (CKD) has been considered a major risk factor for cardiovascular diseases. Although great advances have recently been made in the pathophysiology and treatment of cardiovascular diseases, CKD remains a major global health problem ...
Shunsuke Ito, Masayuki Yoshida
doaj   +3 more sources

Protein-bound uremic toxins impaired mitochondrial dynamics and functions. [PDF]

Oncotarget, 2017
Protein-bound uremic toxins, indoxyl sulfate and p-cresol sulfate, increase oxidative stress and adversely affect chronic kidney disease progression and cardiovascular complications. In this study, we examined whether mitochondria are the target of indoxyl sulfate and p-cresol sulfate intoxication in vivo and in vitro. The kidneys of 10-week-old male B-
Sun CY, Cheng ML, Pan HC, Lee JH, Lee CC.   +4 more
europepmc   +4 more sources

Structure-based discovery of a new type of scaffold compound as binding competitors for protein-bound Uremic Toxins. [PDF]

Sci Rep
Protein-bound uremic toxins (PBUTs) are the main cause of uremia, but traditional hemodialysis is ineffective in removing them because of their strong ability to bind to human serum albumin (HSA), highlighting the need for new treatments.
Wang P, Liu S, Zhao S, Wang Y.
europepmc   +2 more sources