Results 31 to 40 of about 4,243 (164)

MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins

Journal of Materiomics, 2023
MXene, a family of two-dimensional (2D) transition metal carbides and nitrides have attracted extensive interests for many biochemical applications, including tumour elimination, biosensors, and magnetic resonance imaging (MRI).
Tianyi Wang, Wei Gu, Lu Yu, Xin Guo, Jian Yang, Xiaoyu Sun, Jun Guan, Lin Zhou, Chengyin Wang, Hang Yao, Xiuyun Zhang, Guoxiu Wang   +11 more
doaj   +1 more source

Uremic Toxins in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Mechanisms and Therapeutic Targets

Toxins, 2021
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting in uremia. Uremic toxins are classified into three categories: free
Yong Jin Lim, Nicole A. Sidor, Nicholas C. Tonial, Adrian Che, Bradley L. Urquhart   +4 more
doaj   +1 more source

Protein-bound uremic toxins impaired mitochondrial dynamics and functions. [PDF]

Oncotarget, 2017
Protein-bound uremic toxins, indoxyl sulfate and p-cresol sulfate, increase oxidative stress and adversely affect chronic kidney disease progression and cardiovascular complications. In this study, we examined whether mitochondria are the target of indoxyl sulfate and p-cresol sulfate intoxication in vivo and in vitro. The kidneys of 10-week-old male B-
Sun CY, Cheng ML, Pan HC, Lee JH, Lee CC.   +4 more
europepmc   +4 more sources

Protein-bound uremic toxins: putative modulators of calcineurin inhibitor exposure

Nephrology Dialysis Transplantation, 2022
No abstract ...
Laetitia Koppe, Christophe O Soulage
openaire   +4 more sources

Uremic Vascular Calcification: The Pathogenic Roles and Gastrointestinal Decontamination of Uremic Toxins

Toxins, 2020
Uremic vascular calcification (VC) commonly occurs during advanced chronic kidney disease (CKD) and significantly increases cardiovascular morbidity and mortality.
Chia-Ter Chao, Shih-Hua Lin
doaj   +1 more source

Enhanced Removal of Protein-Bound Uremic Toxins Using Displacers: Road to Success? [PDF]

Clin J Am Soc Nephrol, 2019
Patients on maintenance dialysis suffer a substantial mortality risk. Traditionally, this increased mortality is attributed to enhanced cardiovascular damage, in itself mostly linked to hastened calcification and vascular stiffness related to inflammation.
Van Biesen W, Eloot S.
europepmc   +4 more sources

The Microbiome and Uremic Solutes

Toxins, 2022
Uremic retention solutes, especially the protein-bound compounds, are toxic metabolites, difficult to eliminate with progressive renal functional decline.
Nadim Zaidan, Lama Nazzal
doaj   +1 more source

Effects of an SGLT Inhibitor on the Production, Toxicity, and Elimination of Gut-Derived Uremic Toxins: A Call for Additional Evidence

Toxins, 2022
Sodium–glucose cotransporter (SGLT) inhibitors are a class of oral hypoglycemic agents, which, in recent years, have been shown to improve renal and cardiovascular outcomes in patients with diabetic and non-diabetic chronic kidney disease.
Pieter Evenepoel, Bjorn Meijers, Rosalinde Masereeuw, Jerome Lowenstein   +3 more
doaj   +1 more source

Loop diuretics in anuric hemodialysis patients for the clearance of protein-bound uremic toxins. [PDF]

Clin Kidney J
ABSTRACT Background In chronic kidney disease, the accumulation of protein-bound uremic toxins (PBUTs), such as hippuric acid (HA), p-cresyl sulfate (PCS) and indoxyl sulfate (IS), contributes to systemic toxicity and organ dysfunction.
Sánchez-Ospina D, Romero-Cote M, Criado-Bellido L, Saez-Calero MI, Hijazi-Prieto B, Delgado-Cuesta S, Herrera-Gómez F, Mujika-Marticorena M, Gonzalez-Parra E, Izquierdo-Ortiz MJ, Mas-Fontao S.   +10 more
europepmc   +3 more sources

Uremic Toxins and Blood Purification: A Review of Current Evidence and Future Perspectives

Toxins, 2021
Accumulation of uremic toxins represents one of the major contributors to the rapid progression of chronic kidney disease (CKD), especially in patients with end-stage renal disease that are undergoing dialysis treatment.
Stefania Magnani, Mauro Atti
doaj   +1 more source