Enhanced Removal of Protein-Bound Uremic Toxins Using Displacers: Road to Success? [PDF]
Clin J Am Soc Nephrol, 2019 Patients on maintenance dialysis suffer a substantial mortality risk. Traditionally, this increased mortality is attributed to enhanced cardiovascular damage, in itself mostly linked to hastened calcification and vascular stiffness related to inflammation.
Van Biesen W, Eloot S.
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Kidney & Blood Pressure Research, 2023 Introduction Chronic kidney disease (CKD) is a global health problem with increasing incidence which is closely associated with cardiac dysfunction. In CKD uremic toxins accumulate as kidney function declines.
Ebba Sivertsson +5 more
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Protein-Bound Uremic Toxins in Hemodialysis Patients Relate to Residual Kidney Function, Are Not Influenced by Convective Transport, and Do Not Relate to Outcome. [PDF]
Toxins (Basel), 2020 Protein-bound uremic toxins (PBUTs) are predominantly excreted by renal tubular secretion and hardly removed by traditional hemodialysis (HD). Accumulation of PBUTs is proposed to contribute to the increased morbidity and mortality of patients with end ...
van Gelder MK +11 more
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Precision Hemodialysis Using Sorbents to Remove Protein-Bound Uremic Toxins. [PDF]
Kidney360, 2023 Ash SR.
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Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor. [PDF]
Clin J Am Soc Nephrol, 2019 Current hemodialysis techniques fail to efficiently remove the protein-bound uremic toxins p-cresyl sulfate and indoxyl sulfate due to their high degree of albumin binding. Ibuprofen, which shares the same primary albumin binding site with p-cresyl sulfate and indoxyl sulfate, can be infused during hemodialysis to displace these toxins, thereby ...
Madero M +9 more
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Comprehensive Bibliometric Analysis of Uremic Toxin Research [PDF]
ToxinsUremic toxins accumulate as kidney disease progresses, contributing to diverse systemic disorders. Despite numerous studies, no comprehensive mapping has been performed.
Marsuki Hardjo +4 more
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Protein-bound uremic toxins induce tissue remodeling by targeting the EGF receptor. [PDF]
J Am Soc Nephrol, 2015 Indoxyl sulfate and p-cresol sulfate have been suggested to induce kidney tissue remodeling. This study aimed to clarify the molecular mechanisms underlying this tissue remodeling using cultured human proximal renal tubular cells and half-nephrectomized mice treated with indoxyl sulfate or p-cresol sulfate as study models.
Sun CY +7 more
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Factors influencing the removal of protein-bound uremic toxins in hemodiafiltration.
Nefrología (English Edition)INTRODUCTION Protein-bound uremic toxins (PBUTs) have a high affinity for albumin and they are associated with increased cardiovascular morbidity and mortality in hemodialysis patients.
V. Escudero-Saiz +7 more
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Association between Protein-Bound Uremic Toxins and Asymptomatic Cardiac Dysfunction in Patients with Chronic Kidney Disease. [PDF]
Toxins (Basel), 2018 Although the relationship between protein-bound uremic toxins (PBUTs) and cardiac structure and cardiac mortality in chronic kidney disease (CKD) has been studied in the past, the association between cardiac dysfunction and PBUTs has not yet been studied.
Chinnappa S +5 more
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, 2017 If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Glorieux, Griet +3 more
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