Comparative Effects of Acetate- and Citrate-Based Dialysates on Dialysis Dose and Protein-Bound Uremic Toxins in Hemodiafiltration Patients: Exploring the Impact of Calcium and Magnesium Concentrations [PDF]
ToxinsModern hemodialysis employs weak acids as buffers to prevent bicarbonate precipitation with calcium or magnesium. Acetate, the most used acid, is linked to chronic inflammation and poor dialysis tolerance.
Diana Rodríguez-Espinosa +10 more
doaj +2 more sources
Gut Microbiota and Cardiovascular Uremic Toxicities [PDF]
Toxins, 2018 Cardiovascular disease (CVD) remains a major cause of high morbidity and mortality in patients with chronic kidney disease (CKD). Numerous CVD risk factors in CKD patients have been described, but these do not fully explain the high pervasiveness of CVD ...
Manuel T. Velasquez +4 more
doaj +2 more sources
Uremic Toxin Clearance and Cardiovascular Toxicities
Toxins, 2018 Uremic solutes contribute to cardiovascular disease in renal insufficiency. In this review we describe the clearance of selected uremic solutes, which have been associated with cardiovascular disease.
Robert D. Mair +2 more
doaj +2 more sources
Vascular Incompetence in Dialysis Patients—Protein‐Bound Uremic Toxins and Endothelial Dysfunction
Seminars in Dialysis, 2011 Abstract Patients with chronic kidney disease (CKD) have a much higher risk of cardiovascular diseases than the general population. Endothelial dysfunction, which participates in accelerated atherosclerosis, is a hallmark of CKD. Patients with CKD display impaired endothelium‐dependent vasodilatation, elevated soluble biomarkers of ...
Jourde-Chiche, Noemie +4 more
openaire +4 more sources
Immunosenescence and Immune Exhaustion Are Associated with Levels of Protein-Bound Uremic Toxins in Patients on Hemodialysis. [PDF]
Biomedicines, 2023 Tourountzis T +10 more
europepmc +2 more sources
Precision Hemodialysis Using Sorbents to Remove Protein-Bound Uremic Toxins. [PDF]
Kidney360, 2023 Ash SR.
europepmc +3 more sources
Biochimie, 2017 Little is known about potential differences in binding characteristics of protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD) versus healthy controls. The question arises whether eventual differences are attributed to (i) the elevated levels of competing uremic toxins, and/or (ii) post-translational modifications of ...
Olivier Deltombe +6 more
openaire +3 more sources
Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients. [PDF]
PLoS ONE, 2017 Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points.
Sunny Eloot +7 more
doaj +1 more source
MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins
Journal of Materiomics, 2023 MXene, a family of two-dimensional (2D) transition metal carbides and nitrides have attracted extensive interests for many biochemical applications, including tumour elimination, biosensors, and magnetic resonance imaging (MRI).
Tianyi Wang +11 more
doaj +1 more source
Protein-bound uremic toxins: putative modulators of calcineurin inhibitor exposure
Nephrology Dialysis Transplantation, 2022 No abstract ...
Koppe, L., Soulage, C. O.
openaire +4 more sources