Results 41 to 50 of about 4,243 (164)

Protein-bound uremic solutes: The forgotten toxins

Kidney International, 2001
The present concept of dialysis focuses mainly on the removal of small water-soluble compounds, and also, the currently applied kinetic parameters of dialysis adequacy are based on the behavior of water-soluble compounds. Nevertheless, many of the currently known biological effects in uremia are attributable to compounds with different physicochemical ...
Vanholder, Raymond, De Smet, Rita, Lameire, Norbert   +2 more
openaire   +2 more sources

The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients

Scientific Reports, 2021
Protein-bound uremic toxins (Indoxyl sulfate [IS] and p-cresyl sulfate [PCS]) are both associated with cardiovascular (CV) and all-cause mortality in subjects with chronic kidney disease (CKD). Possible mechanisms have not been elucidated.
Ping-Hsun Wu, Yi-Ting Lin, Yi-Wen Chiu, Gabriel Baldanzi, Jiun-Chi Huang, Shih-Shin Liang, Su-Chu Lee, Szu-Chia Chen, Ya-Ling Hsu, Mei-Chuan Kuo, Shang-Jyh Hwang   +10 more
doaj   +1 more source

Protection of Residual Renal Function and Nutritional Treatment: First Step Strategy for Reduction of Uremic Toxins in End-Stage Kidney Disease Patients

Toxins, 2021
The retention of uremic toxins and their pathological effects occurs in the advanced phases of chronic kidney disease (CKD), mainly in stage 5, when the implementation of conventional thrice-weekly hemodialysis is the prevalent and life-saving treatment.
Adamasco Cupisti, Piergiorgio Bolasco, Claudia D’Alessandro, Domenico Giannese, Alice Sabatino, Enrico Fiaccadori   +5 more
doaj   +1 more source

Lymphocyte Phenotypes and Protein-Bound Uremic Toxins as Determinants of Clinical Outcomes in Hemodialysis Patients. [PDF]

Int J Mol Sci
The impact of protein bound uremic toxins (PBUTs) and lymphocyte alterations in morbidity and mortality in patients on hemodialysis (HD) is of great concern. The aim of this study was the assessment of association between PBUTs, immunosenescent lymphocytes’ phenotype and clinical events [cardiovascular, severe infections (hospitalization due to ...
Tourountzis T, Lioulios G, Stai S, Laecke SV, Moysidou E, Christodoulou M, Fouza A, Fylaktou A, Kantartzi K, Glorieux G, Stangou M.   +10 more
europepmc   +4 more sources

AST-120 to target protein-bound uremic toxins improves cardiac output and kidney oxygenation in experimental chronic kidney disease.

Kidney & Blood Pressure Research, 2023
Introduction Chronic kidney disease (CKD) is a global health problem with increasing incidence which is closely associated with cardiac dysfunction. In CKD uremic toxins accumulate as kidney function declines.
Ebba Sivertsson, Sara Ceder, Masaomi Nangaku, Peter Hansell, Lina Nordquist, Fredrik Palm   +5 more
doaj   +1 more source

Protein-Bound Uremic Toxin Profiling as a Tool to Optimize Hemodialysis

PLOS ONE, 2016
We studied various hemodialysis strategies for the removal of protein-bound solutes, which are associated with cardiovascular damage.This study included 10 patients on standard (3 x 4 h/week) high-flux hemodialysis. Blood was collected at the dialyzer inlet and outlet at several time points during a midweek session.
Eloot, Sunny, Schneditz, Daniel, Cornelis, Tom, Van Biesen, Wim, Glorieux, Griet, Dhondt, Annemieke, Kooman, Jeroen, Vanholder, Raymond   +7 more
openaire   +6 more sources

The Impact of CKD on Uremic Toxins and Gut Microbiota

Toxins, 2021
Numerous studies have indicated that the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD) is strictly associated with the accumulation of toxic metabolites in blood and other metabolic compartments.
Jacek Rysz, Beata Franczyk, Janusz Ławiński, Robert Olszewski, Aleksanda Ciałkowska-Rysz, Anna Gluba-Brzózka   +5 more
doaj   +1 more source

Vasculopathy in the setting of cardiorenal syndrome: roles of protein-bound uremic toxins [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2017
Chronic kidney disease (CKD) often leads to and accelerates the progression of cardiovascular disease (CVD), while CVD also causes kidney dysfunction. This bidirectional interaction leads to the development of a complex syndrome known as cardiorenal syndrome (CRS). CRS not only involves both the heart and the kidney but also the vascular system through
Jingbin, Guo, Lu, Lu, Yue, Hua, Kevin, Huang, Ian, Wang, Li, Huang, Qiang, Fu, Aihua, Chen, Paul, Chan, Huimin, Fan, Zhong-Min, Liu, Bing Hui, Wang   +11 more
openaire   +2 more sources

Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate

Toxins, 2014
Protein binding prevents uremic toxins from removal by conventional extracorporeal therapies leading to accumulation in maintenance dialysis patients. Weakening of the protein binding may enhance the dialytic elimination of these toxins.
Eric Devine, Detlef H. Krieter, Marieke Rüth, Joachim Jankovski, Horst-Dieter Lemke   +4 more
doaj   +1 more source

Uremic Toxins in Organ Crosstalk

Frontiers in Medicine, 2021
Many putative uremic toxins—like indoxyl sulfate, p-cresol sulfate, kynurenic acid, uric acid, and CMPF—are organic anions. Both inter-organ and inter-organismal communication are involved.
Jerome Lowenstein, Sanjay K. Nigam
doaj   +1 more source