Results 41 to 50 of about 4,559,139 (173)
Protein-bound uremic toxins impaired mitochondrial dynamics and functions. [PDF]
Oncotarget, 2017 Protein-bound uremic toxins, indoxyl sulfate and p-cresol sulfate, increase oxidative stress and adversely affect chronic kidney disease progression and cardiovascular complications. In this study, we examined whether mitochondria are the target of indoxyl sulfate and p-cresol sulfate intoxication in vivo and in vitro. The kidneys of 10-week-old male B-
Sun CY +4 more
europepmc +4 more sources
Removal of Protein-Bound Uremic Toxins Using Binding Competitors in Hemodialysis: A Narrative Review. [PDF]
Toxins (Basel), 2021 Removal of protein-bound uremic toxins (PBUTs) during conventional dialysis is insufficient. PBUTs are associated with comorbidities and mortality in dialysis patients.
Maheshwari V +3 more
europepmc +2 more sources
Protein-bound uremic solutes: The forgotten toxins
Kidney International, 2001 The present concept of dialysis focuses mainly on the removal of small water-soluble compounds, and also, the currently applied kinetic parameters of dialysis adequacy are based on the behavior of water-soluble compounds. Nevertheless, many of the currently known biological effects in uremia are attributable to compounds with different physicochemical ...
Vanholder, Raymond +2 more
openaire +2 more sources
Scientific Reports, 2021 Protein-bound uremic toxins (Indoxyl sulfate [IS] and p-cresyl sulfate [PCS]) are both associated with cardiovascular (CV) and all-cause mortality in subjects with chronic kidney disease (CKD). Possible mechanisms have not been elucidated.
Ping-Hsun Wu +10 more
doaj +1 more source
Kidney & Blood Pressure Research, 2023 Introduction Chronic kidney disease (CKD) is a global health problem with increasing incidence which is closely associated with cardiac dysfunction. In CKD uremic toxins accumulate as kidney function declines.
Ebba Sivertsson +5 more
doaj +1 more source
pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro
, 2021 Protein-bound uremic toxins (PBUTs) are difficult to remove using conventional dialysis treatment owing to their high protein-binding affinity. As pH changes the conformation of proteins, it may be associated with the binding of uremic toxins.
Keiichi Yamaguchi +7 more
core +1 more source
Association between Protein-Bound Uremic Toxins and Asymptomatic Cardiac Dysfunction in Patients with Chronic Kidney Disease. [PDF]
Toxins (Basel), 2018 Although the relationship between protein-bound uremic toxins (PBUTs) and cardiac structure and cardiac mortality in chronic kidney disease (CKD) has been studied in the past, the association between cardiac dysfunction and PBUTs has not yet been studied.
Chinnappa S +5 more
europepmc +2 more sources
Enhanced Removal of Protein-Bound Uremic Toxins Using Displacers: Road to Success? [PDF]
Clin J Am Soc Nephrol, 2019 Patients on maintenance dialysis suffer a substantial mortality risk. Traditionally, this increased mortality is attributed to enhanced cardiovascular damage, in itself mostly linked to hastened calcification and vascular stiffness related to inflammation.
Van Biesen W, Eloot S.
europepmc +4 more sources
How do Uremic Toxins Affect the Endothelium?
, 2020 Uremic toxins can induce endothelial dysfunction in patients with chronic kidney disease (CKD). Indeed, the structure of the endothelial monolayer is damaged in CKD, and studies have shown that the uremic toxins contribute to the loss of cell–cell ...
Andréa Emilia Marques Stinghen +3 more
core +1 more source
, 2022 Effect of AST-120 to reduced protein bound uremic toxins on in vivo kidney ...
Ebba Sivertsson (11667481)
core +1 more source