Changes in the Conformational State of Hemoglobin in Hemodialysed Patients with Chronic Renal Failure [PDF]
, 2015 The aim of this study was to evaluate the properties of internal components of erythrocytes in chronic renal failure (CRF) patients undergoing hemodialysis (HD) in comparison to control subjects.
Gwozdzinski, Krzysztof +1 more
core +4 more sources
Dinucleoside polyphosphates : newly detected uraemic compounds with an impact on leucocyte oxidative burst [PDF]
, 2009 Background. Dinucleoside polyphosphates (NpnN) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells.
Dhondt, Annemieke +5 more
core +1 more source
The Impact of CKD on Uremic Toxins and Gut Microbiota
Toxins, 2021 Numerous studies have indicated that the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD) is strictly associated with the accumulation of toxic metabolites in blood and other metabolic compartments.
Jacek Rysz +5 more
doaj +1 more source
Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate
Toxins, 2014 Protein binding prevents uremic toxins from removal by conventional extracorporeal therapies leading to accumulation in maintenance dialysis patients. Weakening of the protein binding may enhance the dialytic elimination of these toxins.
Eric Devine +4 more
doaj +1 more source
Uremic Toxins in Organ Crosstalk
Frontiers in Medicine, 2021 Many putative uremic toxins—like indoxyl sulfate, p-cresol sulfate, kynurenic acid, uric acid, and CMPF—are organic anions. Both inter-organ and inter-organismal communication are involved.
Jerome Lowenstein, Sanjay K. Nigam
doaj +1 more source
Prebiotic, Probiotic, and Synbiotic Supplementation in Chronic Kidney Disease: A Systematic Review and Meta-analysis [PDF]
, 2019 Gut dysbiosis has been implicated in the pathogenesis of chronic kidney disease (CKD). Restoring gut microbiota with prebiotic, probiotic, and synbiotic supplementation has emerged as a potential therapeutic intervention but has not been systematically ...
Campbell, Katrina L. +3 more
core +1 more source
Uraemic toxins and new methods to control their accumulation : game changers for the concept of dialysis adequacy [PDF]
, 2015 The current concept of an adequate dialysis based only on the dialysis process itself is rather limited. We now have considerable knowledge of uraemic toxicity and improved tools for limiting uraemic toxin accumulation. It is time to make use of these. A
Glorieux, Griet, Tattersall, James
core +2 more sources
A novel mathematical model of protein-bound uremic toxin kinetics during hemodialysis [PDF]
Scientific Reports, 2017 AbstractProtein-bound uremic toxins (PBUTs) are difficult to remove by conventional hemodialysis; a high degree of protein binding reduces the free fraction of toxins and decreases their diffusion across dialyzer membranes. Mechanistic understanding of PBUT kinetics can open new avenues to improve their dialytic removal.
Vaibhav Maheshwari +5 more
openaire +2 more sources
Animal Models for Studying Protein-Bound Uremic Toxin Removal—A Systematic Review
International Journal of Molecular Sciences, 2023 Protein-bound uremic toxins (PBUTs) are associated with the progression of chronic kidney disease (CKD) and its associated morbidity and mortality. The conventional dialysis techniques are unable to efficiently remove PBUTs due to their plasma protein binding.
Sabbir Ahmed +7 more
openaire +4 more sources
Protein-Bound Uremic Toxin Profiling as a Tool to Optimize Hemodialysis
PLOS ONE, 2016 We studied various hemodialysis strategies for the removal of protein-bound solutes, which are associated with cardiovascular damage.This study included 10 patients on standard (3 x 4 h/week) high-flux hemodialysis. Blood was collected at the dialyzer inlet and outlet at several time points during a midweek session.
Eloot, Sunny +7 more
openaire +6 more sources