Results 51 to 60 of about 4,243 (164)

Comparable Efficacy of Medium Cut-Off Dialysis Plus HA130 Hemoadsorption and Postfilter Hemodiafiltration in Removing Protein-Bound Uremic Toxins

Kidney Medicine
Rationale & Objective: Protein-bound uremic toxins, including indoxyl sulfate and p-cresyl sulfate, are poorly removed by conventional dialysis and contribute to cardiovascular, inflammatory, and neurological complications in end-stage kidney disease.
Gonzalo Ramírez-Guerrero, Cristian Pedreros-Rosales, María José Cáceres, Katherine Saravia, Alejandra Urizar, Armando Rojas, Thiago Reis, Hans Müller-Ortiz, Claudio Ronco   +8 more
doaj   +1 more source

The association of uremic toxins and inflammation in hemodialysis patients. [PDF]

PLoS ONE, 2014
Cardiovascular disease is the leading cause of mortality in hemodialysis patients and is associated with chronic inflammation. Elevation of uremic toxins, particular protein-bound uremic toxins, is a possible cause of hyper-inflammation in hemodialysis ...
Heng-Jung Hsu, Chiung-Hui Yen, I-Wen Wu, Kuang-Hung Hsu, Chih-Ken Chen, Chiao-Yin Sun, Chia-Chi Chou, Chun-Yu Chen, Chi-Jen Tsai, Mai-Szu Wu, Chin-Chan Lee   +10 more
doaj   +1 more source

Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor. [PDF]

Clin J Am Soc Nephrol, 2019
Current hemodialysis techniques fail to efficiently remove the protein-bound uremic toxins p-cresyl sulfate and indoxyl sulfate due to their high degree of albumin binding. Ibuprofen, which shares the same primary albumin binding site with p-cresyl sulfate and indoxyl sulfate, can be infused during hemodialysis to displace these toxins, thereby ...
Madero M, Cano KB, Campos I, Tao X, Maheshwari V, Brown J, Cornejo B, Handelman G, Thijssen S, Kotanko P.   +9 more
europepmc   +4 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Molecular and Cellular Mechanisms that Induce Arterial Calcification by Indoxyl Sulfate and P-Cresyl Sulfate

Toxins, 2020
The protein-bound uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate (PCS), are considered to be harmful vascular toxins. Arterial media calcification, or the deposition of calcium phosphate crystals in the arteries, contributes significantly to ...
Britt Opdebeeck, Patrick C. D’Haese, Anja Verhulst   +2 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Protein-Bound Uremic Toxins Stimulate Crosstalk between Leukocytes and Vessel Wall [PDF]

Journal of the American Society of Nephrology, 2013
Leukocyte activation and endothelial damage both contribute to cardiovascular disease, a major cause of morbidity and mortality in CKD. Experimental in vitro data link several protein-bound uremic retention solutes to the modulation of inflammatory stimuli, including endothelium and leukocyte responses and cardiovascular damage, corroborating ...
Pletinck, A., Glorieux, G., Schepers, E., Cohen, G., Gondouin, B., Landschoot, M. Van, Eloot, S., Rops, L.W.M.M., Voorde, J. van de, Vriese, A. de, Vlag, J. van der, Brunet, P., Biesen, W. Van, Vanholder, R.   +13 more
openaire   +3 more sources

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

A novel mathematical model of protein-bound uremic toxin kinetics during hemodialysis [PDF]

Scientific Reports, 2017
AbstractProtein-bound uremic toxins (PBUTs) are difficult to remove by conventional hemodialysis; a high degree of protein binding reduces the free fraction of toxins and decreases their diffusion across dialyzer membranes. Mechanistic understanding of PBUT kinetics can open new avenues to improve their dialytic removal.
Vaibhav Maheshwari, Stephan Thijssen, Xia Tao, Doris Fuertinger, Franz Kappel, Peter Kotanko   +5 more
openaire   +2 more sources

Animal Models for Studying Protein-Bound Uremic Toxin Removal—A Systematic Review

International Journal of Molecular Sciences, 2023
Protein-bound uremic toxins (PBUTs) are associated with the progression of chronic kidney disease (CKD) and its associated morbidity and mortality. The conventional dialysis techniques are unable to efficiently remove PBUTs due to their plasma protein binding.
Sabbir Ahmed, Joost C. de Vries, Jingyi Lu, Milan H. Verrijn Stuart, Silvia M. Mihăilă, Robin W. M. Vernooij, Rosalinde Masereeuw, Karin G. F. Gerritsen   +7 more
openaire   +3 more sources