Results 51 to 60 of about 15,339 (215)

Single needle hemodialysis : is the past the future? [PDF]

, 2020
Whereas the usual way to gain access to the vascular bed for hemodialysis is by inserting two needles, an alternative option based on the introduction of only one needle has been available for several decades.
Vanholder, Raymond
core   +2 more sources

Effects of an SGLT Inhibitor on the Production, Toxicity, and Elimination of Gut-Derived Uremic Toxins: A Call for Additional Evidence

Toxins, 2022
Sodium–glucose cotransporter (SGLT) inhibitors are a class of oral hypoglycemic agents, which, in recent years, have been shown to improve renal and cardiovascular outcomes in patients with diabetic and non-diabetic chronic kidney disease.
Pieter Evenepoel, Bjorn Meijers, Rosalinde Masereeuw, Jerome Lowenstein   +3 more
doaj   +1 more source

Serum levels and removal by haemodialysis and haemodiafiltration of tryptophan-derived uremic toxins in ESKD patients [PDF]

, 2020
Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes.
Adoberg, A, Arduan Ortiz, A, Arund, J, Dhondt, Annemieke, Fernström, A, Fridolin, I, Glorieux, Griet, Gonzales-Parra, E, Leis, L, Luman, M, Paats, J, Perez-Gomez, VM, Pilt, K, Sanchez-Ospina, D, Segelmark, M, Uhlin, F   +15 more
core   +1 more source

The Microbiome and Uremic Solutes

Toxins, 2022
Uremic retention solutes, especially the protein-bound compounds, are toxic metabolites, difficult to eliminate with progressive renal functional decline.
Nadim Zaidan, Lama Nazzal
doaj   +1 more source

Protection of Residual Renal Function and Nutritional Treatment: First Step Strategy for Reduction of Uremic Toxins in End-Stage Kidney Disease Patients

Toxins, 2021
The retention of uremic toxins and their pathological effects occurs in the advanced phases of chronic kidney disease (CKD), mainly in stage 5, when the implementation of conventional thrice-weekly hemodialysis is the prevalent and life-saving treatment.
Adamasco Cupisti, Piergiorgio Bolasco, Claudia D’Alessandro, Domenico Giannese, Alice Sabatino, Enrico Fiaccadori   +5 more
doaj   +1 more source

Binding of bromocresol green and bromocresol purple to albumin in hemodialysis patients [PDF]

, 2017
BACKGROUND: Colorimetric albumin assays based on binding to bromocresol purple (BCP) and bromocresol green (BCG) yield different results in chronic kidney disease. Altered dye binding of carbamylated albumin has been suggested as a cause.
Delanghe, Joris, Delanghe, Sigurd, Eloot, Sunny, Glorieux, Griet, Pletinck, Anneleen, Schepers, Eva, Speeckaert, Marijn, Van Biesen, Wim, Van de Velde, Nadeige   +8 more
core   +1 more source

The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients

Scientific Reports, 2021
Protein-bound uremic toxins (Indoxyl sulfate [IS] and p-cresyl sulfate [PCS]) are both associated with cardiovascular (CV) and all-cause mortality in subjects with chronic kidney disease (CKD). Possible mechanisms have not been elucidated.
Ping-Hsun Wu, Yi-Ting Lin, Yi-Wen Chiu, Gabriel Baldanzi, Jiun-Chi Huang, Shih-Shin Liang, Su-Chu Lee, Szu-Chia Chen, Ya-Ling Hsu, Mei-Chuan Kuo, Shang-Jyh Hwang   +10 more
doaj   +1 more source

Protein-bound uremic solutes: The forgotten toxins

Kidney International, 2001
The present concept of dialysis focuses mainly on the removal of small water-soluble compounds, and also, the currently applied kinetic parameters of dialysis adequacy are based on the behavior of water-soluble compounds. Nevertheless, many of the currently known biological effects in uremia are attributable to compounds with different physicochemical ...
Vanholder, Raymond, De Smet, Rita, Lameire, Norbert   +2 more
openaire   +2 more sources

Uremic Toxins and Blood Purification: A Review of Current Evidence and Future Perspectives

Toxins, 2021
Accumulation of uremic toxins represents one of the major contributors to the rapid progression of chronic kidney disease (CKD), especially in patients with end-stage renal disease that are undergoing dialysis treatment.
Stefania Magnani, Mauro Atti
doaj   +1 more source

Protein-Bound Uremic Toxins Stimulate Crosstalk between Leukocytes and Vessel Wall [PDF]

Journal of the American Society of Nephrology, 2013
Leukocyte activation and endothelial damage both contribute to cardiovascular disease, a major cause of morbidity and mortality in CKD. Experimental in vitro data link several protein-bound uremic retention solutes to the modulation of inflammatory stimuli, including endothelium and leukocyte responses and cardiovascular damage, corroborating ...
Pletinck, A., Glorieux, G., Schepers, E., Cohen, G., Gondouin, B., Landschoot, M. Van, Eloot, S., Rops, L.W.M.M., Voorde, J. van de, Vriese, A. de, Vlag, J. van der, Brunet, P., Biesen, W. Van, Vanholder, R.   +13 more
openaire   +3 more sources