Results 81 to 90 of about 4,559,139 (173)

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source

Inflammatory Cytokines as Uremic Toxins: “Ni Son Todos Los Que Estan, Ni Estan Todos Los Que Son” [PDF]

, 2017
Chronic kidney disease is among the fastest growing causes of death worldwide. An increased risk of all-cause and cardiovascular death is thought to depend on the accumulation of uremic toxins when glomerular filtration rate falls.
Fernandez-Fernandez, Beatriz, Soledad Pizarro-Sánchez, Esmeralda Castillo-Rodríguez, Maria Sanchez-Niño, Adrian Ramos, Catalina Martin-Cleary, Ana Sanz, Sanz, Ana B, Pizarro-Sánchez, Soledad, Ramos, Adrian M, Martin-Cleary, Catalina, Castillo-Rodríguez, Esmeralda, Beatriz Fernandez-Fernandez, Sanchez-Niño, Maria Dolores, Alberto Ortiz, Ortiz, Alberto   +15 more
core   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Research advances in the mechanisms of indoxyl sulfate and sarcopenia in chronic kidney disease

Linchuang shenzangbing zazhi
Sarcopenia in chronic kidney disease （CKD） occurs mainly in patients with end-stage renal disease （ESRD） on hemodialysis. The potential causes are insufficient nutrition intake, protein and energy consumption, inflammatory cytokines, oxidative stress ...
Shu-yuan Yang, Yan Zhang, Yan-kun Luo
doaj   +1 more source

Liver Injury Repair and Regeneration: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 11, November 2026.
This review outlines the spatiotemporal framework of liver injury repair and regeneration, orchestrated by molecular signaling, multicellular niche crosstalk, metabolic reprogramming, and interorgan communication. Post‑injury regenerative cascades (initiation, proliferation, termination) rely on crosstalk between hepatocytes, Kupffer cells, hepatic ...
Mingyue Pan, Ni An, Yutian Feng, Yuelei Hu, Chongqin Pan, Yuxin Su, Yuanzheng Huang, Tanqing Long, Qi Wang, Qingru Song, Pengfei Li, Xiaomeng Li, Wenzhen Yin, Zhiyuan Hu, Xiaoxuan Liu, Juan Liu   +15 more
wiley   +1 more source

Gastroschisis‐Like Defect in a Crossbred Bovine Calf: Anatomical, Clinical and Surgical Perspectives

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
A gastroschisis‐like defect was observed in a one‐day‐old, crossbred bovine calf with evisceration of the pyloric abomasum and small intestine, likely resulting from prenatal rupture of an omphalocele. The calf presented with lethargy, hypothermia and metabolic derangements, along with elevated renal biomarkers.
Mohammad Raguib Munif, Tanjin Tamanna Mumu   +1 more
wiley   +1 more source

Furosemide and Serum Protein-Bound Uremic Toxin Concentrations in Patients With CKD

Kidney International Reports
Furosemide is commonly prescribed to patients with chronic kidney disease (CKD) but may impair the kidney's excretion of protein-bound uremic toxins (PBUTs) via the organic anion transporters 1 and 3 (OAT1 and OAT3). We evaluated the association between furosemide prescription (status and dose level) and the serum concentrations of free OAT1/3 ...
Margaux Costes-Albrespic, Natalia Alencar de Pinho, Islam Amine Larabi, Carolla El Chamieh, Solène M. Laville, Denis Fouque, Maurice Laville, Luc Frimat, Jean-Claude Alvarez, Ziad A. Massy, Sophie Liabeuf, Natalia Alencar De Pinho, Dorothée Cannet, Christian Combe, Denis Fouque, Luc Frimat, Aghilès Hamroun, Yves-Edouard Herpe, Christian Jacquelinet, Maurice Laville, Sophie Liabeuf, Ziad A. Massy, Pascal Morel, Christophe Pascal, Roberto Pecoits-Filho, Joost Schanstra, Bénédicte Stengel, Céline Lange, Oriane Lambert, Marie Metzger   +29 more
openaire   +3 more sources

Role of Uremic Toxins in Early Vascular Ageing and Calcification

, 2021
In patients with advanced chronic kidney disease (CKD), the accumulation of uremic toxins, caused by a combination of decreased excretion secondary to reduced kidney function and increased generation secondary to aberrant expression of metabolite genes ...
Kyriakidis, NC, Peter Stenvinkel, Lu Dai, Gabriela Cobo, Stenvinkel, P,, Cobo, G, Dai, L,, Nikolaos C. Kyriakidis, Lindholm, B,, Bengt Lindholm   +9 more
core   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, Volume 30, Issue 5, Page 627-640, October 2026.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Evaluation of the Toxin-to-Protein Binding Rates during Hemodialysis Using Sorbent-Loaded Mixed-Matrix Membranes

Applied Sciences, 2018
The transport and reaction phenomena that take place in multi-layered mixed-matrix membranes with activated carbon (AC) sorbents that are expected to improve extra-corporeal blood purification, are studied at the macroscopic scale.
Christos S. Stiapis, Eugene D. Skouras, Denys Pavlenko, Dimitrios Stamatialis, Vasilis N. Burganos   +4 more
doaj   +1 more source