Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy
Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva +5 more
wiley +1 more source
Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic cornerstone of model‐informed drug development (MIDD), providing evidence for regulatory decisions. PBPK models integrate physiological and pharmacological data and have been applied across a plethora of contexts of use, including assessing drug–drug interactions (DDIs ...
Marylore Chenel +6 more
wiley +1 more source
An In Vitro System for Studying Toxin Transport Across Hemodialysis Membranes
Artificial Organs, Volume 50, Issue 7, Page 988-1006, July 2026.Development of an in vitro hemodialysis (HD) system based on mini dialyzers for evaluating hemodialysis membranes under physiologically relevant conditions. ABSTRACT Background Healthy kidneys regulate acid–base balance and electrolytes, produce hormones, and clear excess fluids and uremic toxins.
M. Torrents‐Yeste +7 more
wiley +1 more source
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
Mechanisms and Clinical Manifestations of Age‐Related Impairment in Wound Healing
International Wound Journal, Volume 23, Issue 7, July 2026.ABSTRACT Chronic wounds account for a considerable burden on the overall US healthcare system, affecting an estimated 10.2 million people and costing as much as $148 billion dollars in 2022 alone. Elderly patients suffer disproportionately, as nearly 85% of the chronic wound population is over the age of 65 years old.
Daniel A. Rabin +10 more
wiley +1 more source
Small SciencePeople with end‐stage chronic kidney disease (CKD) require routine dialysis treatments to remove uremic toxins from the blood in order to minimize toxic symptoms.
Fátima Guerrero +4 more
doaj +1 more source
Uremic Toxins and Hemodiafiltration: From Molecular Mechanisms to Clinical Outcomes
ToxinsUremic syndrome results from the accumulation of biologically active solutes that contribute to inflammation, oxidative stress, endothelial dysfunction, cardiovascular disease, anemia, CKD–mineral and bone disorder, and protein-energy wasting in patients
Stefano Stuard +5 more
doaj +1 more source
The influence of uremic toxins on low bone turnover disease in chronic kidney disease
Tzu Chi Medical JournalUremic toxins play a crucial role in the development of low bone turnover disease in chronic kidney disease (CKD) through the induction of oxidative stress.
Giou-Teng Yiang +6 more
doaj +1 more source
A Novel Strategy for Enhanced Sequestration of Protein-Bound Uremic Toxins Using Smart Hybrid Membranes. [PDF]
J Funct Biomater, 2023 Lopes M +3 more
europepmc +1 more source
The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury. [PDF]
Toxins (Basel), 2022 Caillard P +7 more
europepmc +1 more source