Results 11 to 20 of about 4,559,139 (173)
Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes [PDF]
Toxins, 2019 To better understand the kinetics of protein-bound uremic toxins (PBUTs) during hemodialysis (HD), we investigated the distribution of hippuric acid (HA), indole-3-acetic acid (IAA), indoxyl sulfate (IS), and p-cresyl sulfate (pCS) in erythrocytes of HD ...
Olivier Deltombe +5 more
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Uremic Toxins and Protein-Bound Therapeutics in AKI and CKD: Up-to-Date Evidence [PDF]
Toxins, 2021 Uremic toxins are defined as harmful metabolites that accumulate in the human body of patients whose renal function declines, especially chronic kidney disease (CKD) patients. Growing evidence demonstrates the deteriorating effect of uremic toxins on CKD
Jia-Huang Chen, Chih-Kang Chiang
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Toxins, 2020 Uremic vascular calcification (VC) commonly occurs during advanced chronic kidney disease (CKD) and significantly increases cardiovascular morbidity and mortality.
Chia-Ter Chao, Shih-Hua Lin
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Food-Derived Uremic Toxins in Chronic Kidney Disease [PDF]
Toxins, 2023 Patients with chronic kidney disease (CKD) have a higher cardiovascular risk compared to the average population, and this is partially due to the plasma accumulation of solutes known as uremic toxins.
Mara Lauriola +4 more
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Disposition and clinical implications of protein-bound uremic toxins
Clinical Science, 2017 In patients with chronic kidney disease (CKD), adequate renal clearance is compromised, resulting in the accumulation of a plethora of uremic solutes. These uremic retention solutes, also named uremic toxins, are a heterogeneous group of organic compounds with intrinsic biological activities, many of which are too large to be filtered and/or are ...
Jansen, J. +4 more
core +7 more sources
The Dual Roles of Protein-Bound Solutes as Toxins and Signaling Molecules in Uremia [PDF]
Toxins, 2022 In patients with severe kidney disease, renal clearance is compromised, resulting in the accumulation of a plethora of endogenous waste molecules that cannot be removed by current dialysis techniques, the most often applied treatment.
Rosalinde Masereeuw
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Toxins, 2021 Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting in uremia. Uremic toxins are classified into three categories: free
Yong Jin Lim +4 more
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Uremic Toxins and Blood Purification: A Review of Current Evidence and Future Perspectives
Toxins, 2021 Accumulation of uremic toxins represents one of the major contributors to the rapid progression of chronic kidney disease (CKD), especially in patients with end-stage renal disease that are undergoing dialysis treatment.
Stefania Magnani, Mauro Atti
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Toxins, 2021 The retention of uremic toxins and their pathological effects occurs in the advanced phases of chronic kidney disease (CKD), mainly in stage 5, when the implementation of conventional thrice-weekly hemodialysis is the prevalent and life-saving treatment.
Adamasco Cupisti +5 more
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The Interplay between Uremic Toxins and Albumin, Membrane Transporters and Drug Interaction
Toxins, 2022 Uremic toxins are a heterogeneous group of molecules that accumulate in the body due to the progression of chronic kidney disease (CKD). These toxins are associated with kidney dysfunction and the development of comorbidities in patients with CKD, being ...
Regiane Stafim da Cunha +6 more
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