Results 11 to 20 of about 15,339 (215)

Protein-Bound Uremic Toxins: New Insight from Clinical Studies [PDF]

Toxins, 2011
The uremic syndrome is attributed to the progressive retention of a large number of compounds which, under normal conditions, are excreted by healthy kidneys. The compounds are called uremic toxins when they interact negatively with biological functions.
Ziad A. Massy, Sophie Liabeuf, Tilman B. Drüeke   +2 more
doaj   +5 more sources

Comparative Effects of Acetate- and Citrate-Based Dialysates on Dialysis Dose and Protein-Bound Uremic Toxins in Hemodiafiltration Patients: Exploring the Impact of Calcium and Magnesium Concentrations [PDF]

Toxins
Modern hemodialysis employs weak acids as buffers to prevent bicarbonate precipitation with calcium or magnesium. Acetate, the most used acid, is linked to chronic inflammation and poor dialysis tolerance.
Diana Rodríguez-Espinosa, Elena Cuadrado-Payán, Naira Rico, Mercè Torra, Rosa María Fernández, Miquel Gómez, Laura Morantes, Gregori Casals, Maria Rodriguez-Garcia, Francisco Maduell, José Jesús Broseta   +10 more
doaj   +3 more sources

Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients. [PDF]

PLoS ONE, 2017
Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points.
Sunny Eloot, Wim Van Biesen, Sanne Roels, Willem Delrue, Eva Schepers, Annemieke Dhondt, Raymond Vanholder, Griet Glorieux   +7 more
doaj   +20 more sources

Predictive value of protein-bound uremic toxins for heart failure in patients with chronic kidney disease. [PDF]

ESC Heart Fail, 2023
This retrospective cohort study aimed to be the first to evaluate the association between plasma protein‐bound uremic toxins (PBUTs) concentrations, echocardiographic parameters of heart failure (HF), and incident HF events in patients with chronic ...
Zwaenepoel B, De Backer T, Glorieux G, Verbeke F.   +3 more
europepmc   +2 more sources

Loop diuretics in anuric hemodialysis patients for the clearance of protein-bound uremic toxins. [PDF]

Clin Kidney J
Background In chronic kidney disease, the accumulation of protein-bound uremic toxins (PBUTs), such as hippuric acid (HA), p-cresyl sulfate (PCS) and indoxyl sulfate (IS), contributes to systemic toxicity and organ dysfunction.
Sánchez-Ospina D, Romero-Cote M, Criado-Bellido L, Saez-Calero MI, Hijazi-Prieto B, Delgado-Cuesta S, Herrera-Gómez F, Mujika-Marticorena M, Gonzalez-Parra E, Izquierdo-Ortiz MJ, Mas-Fontao S.   +10 more
europepmc   +2 more sources

Lymphocyte Phenotypes and Protein-Bound Uremic Toxins as Determinants of Clinical Outcomes in Hemodialysis Patients. [PDF]

Int J Mol Sci
The impact of protein bound uremic toxins (PBUTs) and lymphocyte alterations in morbidity and mortality in patients on hemodialysis (HD) is of great concern.
Tourountzis T, Lioulios G, Stai S, Laecke SV, Moysidou E, Christodoulou M, Fouza A, Fylaktou A, Kantartzi K, Glorieux G, Stangou M.   +10 more
europepmc   +2 more sources

Kidney clearances of protein-bound uremic toxins predict outcomes in chronic kidney disease: a prospective cohort study. [PDF]

Ren Fail
This prospective cohort study investigated the kidney clearance of protein-bound uremic toxins (PBUTs)—specifically, indole sulfate (IS), p-cresol sulfate (pCS), and indole-3-acetic acid (IAA)—across various stages of chronic kidney disease (CKD) stages ...
Xie D, Jiang M, Li J, Chen Y, Ding F, Wang W.   +5 more
europepmc   +2 more sources

A highly biocompatible polyethyleneimine/sulfonated polysulfone hemoperfusion microsphere with tailored surface charge for rapid and efficient removal of major protein-bound uremic toxins from simulated human plasma. [PDF]

Regen Biomater
Conventional hemodialysis and hemodiafiltration prove less effective at removing protein-bound uremic toxins (PBUTs) from the bloodstream of end-stage renal disease patients, primarily because PBUTs cannot pass through the small pores in the polymeric ...
Wang S, Liang J, Chen Y, Liu X, Tong D, Li Y, Zhao W, Su B, Zhao C.   +8 more
europepmc   +2 more sources

Effect of Membrane Permeance and System Parameters on the Removal of Protein-Bound Uremic Toxins in Hemodialysis. [PDF]

Ann Biomed Eng, 2023
Inadequate clearance of protein-bound uremic toxins (PBUTs) during dialysis is associated with morbidities in chronic kidney disease patients. The development of high-permeance membranes made from materials such as graphene raises the question whether ...
Chow CM, Persad AH, Karnik R.
europepmc   +2 more sources

Removal of Protein-Bound Uremic Toxins Using Binding Competitors in Hemodialysis: A Narrative Review. [PDF]

Toxins (Basel), 2021
Removal of protein-bound uremic toxins (PBUTs) during conventional dialysis is insufficient. PBUTs are associated with comorbidities and mortality in dialysis patients.
Maheshwari V, Tao X, Thijssen S, Kotanko P.   +3 more
europepmc   +2 more sources