British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska +2 more
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Atypical hemolytic uremic syndrome : update on the complement system and what is new [PDF]
, 2010 Atypical hemolytic uremic syndrome (aHUS) is a rare disease of microangiopathic hemolytic anemia, thrombocytopenia, and predominant renal impairment. It is characterized by the absence of Shiga toxin-producing bacteria as a triggering factor.
Dickenmann, Michael +2 more
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The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7 [PDF]
, 2014 Classical studies have focused on the role that individual regulators play in controlling virulence gene expression. An emerging theme, however, is that bacterial metabolism also plays a key role in this process.
Abernathy +59 more
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Investigation of hepatocyte signaling pathways in chronic kidney disease : clinical and experimental studies [PDF]
, 2016 Chronic kidney disease (CKD) is defined as a loss of renal function from any cause and lasting for more than three months. The CKD phenotype is similar across multiple etiologies, suggesting that renal damage itself is a dominant factor. Thus, regardless
Li, Meng
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Effects of Maternal Low Protein Diet on Expression of Drug Transporters in the Blood-Brain Barrier of Adult Offspring [PDF]
, 2012 Adverse uterine environment, manifested as low birth weight (LBW), has been shown to predispose individuals to hypertension, diabetes, and obesity by mechanisms that are just beginning to be understood.
Hastings, Bonnie L.
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Chronic kidney disease and fibrosis : the role of uremic retention solutes [PDF]
, 2015 Chronic kidney disease (CKD) is a major global health concern, and the uremic state is highly associated with fibrogenesis in several organs and tissues.
Glorieux, Griet +4 more
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Association between protein-bound uremic toxins and asymptomatic cardiac dysfunction in patients with chronic kidney disease [PDF]
, 2018 Although the relationship between protein-bound uremic toxins (PBUTs) and cardiac structure and cardiac mortality in chronic kidney disease (CKD) has been studied in the past, the association between cardiac dysfunction and PBUTs has not yet been studied.
Chinnappa, Shanmugakumar +5 more
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Toxins, 2019 High serum levels of gut-derived uremic toxins, especially p-cresyl sulfate (pCS), indoxyl sulfate (IS) and indole acetic acid (IAA), have been linked to adverse outcomes in patients with chronic kidney disease (CKD).
Youssef Bennis +10 more
doaj +1 more source
A novel mechanism of bacterial toxin transfer within host blood cell-derived microvesicles.
PLoS Pathogens, 2015 Shiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli, which are non-invasive strains that can lead to hemolytic uremic syndrome (HUS), associated with renal failure and death.
Anne-lie Ståhl +9 more
doaj +1 more source
Protein-Bound Uremic Toxins Binding to Human Serum Albumin
Education and Research ArchiveKidney failure is a global health concern, exacerbated by the accumulation of uremic metabolites that persist despite conventional treatments such as hemodialysis (HD). A significant subset of these metabolites, termed protein-bound uremic toxins (PBUTs), bind tightly to human serum albumin (HSA), limiting their removal through traditional separation ...
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