Results 111 to 120 of about 4,792 (191)

Primary Human Derived Blood Outgrowth Endothelial Cells: An Appropriate In Vitro Model to Study Shiga Toxin Mediated Damage of Endothelial Cells

Toxins, 2020
Hemolytic uremic syndrome (HUS) is a rare disease primarily characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Endothelial damage is the hallmark of the pathogenesis of HUS with an infection with the Shiga toxin (Stx) producing
Wouter J. C. Feitz, Nicole C. A. J. van de Kar, Ian Cheong, Thea J. A. M. van der Velden, Carolina G. Ortiz-Sandoval, Dorothea Orth-Höller, Lambert P. J. W. van den Heuvel, Christoph Licht   +7 more
doaj   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, Volume 30, Issue 4, Page 523-529, August 2026.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Determination of the binding properties of the uremic toxin phenylacetic acid to human serum albumin [PDF]

, 2016
Uremic toxins are compounds normally excreted in urine that accumulate in patients with chronic kidney disease as a result of decreased renal clearance. Phenylacetic acid (PAA) has been identified as a new protein bound uremic toxin.
Mafra, Denise, Soulage, Christophe, Soula, Hédi, Stockler-Pinto, Milena B., Saldanha, Juliana F., Fouque, Denis, Yi, Dan, Chambert, Stéphane   +7 more
core   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

The Choice of Anti-Inflammatory Influences the Elimination of Protein-Bound Uremic Toxins

Toxins
Pain is a frequent and disturbing symptom among hemodialysis patients. Protein-bound uremic toxins (PBUTs) are related to cardiovascular and overall mortality, and they are difficult to remove with current hemodialysis treatments. The PBUT displacers, such as furosemide, tryptophan, or ibuprofen, may be promising new strategies for improving their ...
Víctor Joaquín Escudero-Saiz, Elena Cuadrado-Payán, María Rodriguez-Garcia, Gregori Casals, Lida María Rodas, Néstor Fontseré, María del Carmen Salgado, Carla Bastida, Nayra Rico, José Jesús Broseta, Francisco Maduell   +10 more
openaire   +3 more sources

Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom [PDF]

, 2010
Atypical haemolytic uraemic syndrome (aHUS) is associated with a poor prognosis with regard to survival at presentation, recovery of renal function and transplantation.
Sam Machin, ?, ?, Machin, Sam, Tim H. J. Goodship, Goodship, Tim H J, Stephen J. Wigmore, Taylor, C Mark, Wigmore, Stephen J, C. Mark Taylor   +8 more
core   +1 more source

Electroacupuncture Treatment on Sarcopenia in Patients Undergoing Maintenance Haemodialysis: An Effective Therapy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Electroacupuncture (EA) treatment has been utilized for recovery from neuromuscular‐related diseases and may play a significant role in the treatment of sarcopenia. This interventional, randomized controlled clinical study aims to explore the efficacy of EA treatment in maintenance haemodialysis (MHD) patients with sarcopenia ...
Ruoxin Chen, Qinqin Qian, Bin Wang, Ruoyang Chen, Liuping Zhang, Hui Jin, Jun Zhu, Zuolin Li, Jianyun Gao, Hong Liu   +9 more
wiley   +1 more source

The Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive‐Like Behavior in Mice

Brain and Behavior, Volume 16, Issue 7, July 2026.
Repetitive transcranial magnetic stimulation (rTMS) ameliorates chronic unpredictable mild stress (CUMS)‐induced depressive‐like behaviors in mice by modulating key tryptophan metabolism pathways, as evidenced by the restoration of serotonin levels and reduction of neuroactive metabolites.
Gao Yuan, Wang Zihao, Leng Yujia, Luan Rongrong, Zhao Xin, Yang Juanini, Liu Junchang, Feng Yuchao, Wang Peng   +8 more
wiley   +1 more source

Cingulate Gradient Dysfunction in End‐Stage Renal Disease: Associations With Clinical Phenotypes and Exploratory Transcriptomic Signatures

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
End‐stage renal disease (ESRD) patients exhibited significant cingulate gradient dysfunction, which was significantly correlated with multiple functional domains, serum urea, and hemoglobin levels. Spatially, these alterations were correlated with genes enriched in neurodegenerative pathways.
Peng Li, Jun‐Ya Mu, Xin‐Yi Zhu, Hui‐Jie Yuan, Zhao‐Yao Luo, Qian‐Ge Zhu, Xuan Niu, Xiu‐Long Feng, Yu Han, Ting Ge, Chen‐Xi Wang, Wen Wang, Ming Zhang   +12 more
wiley   +1 more source

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, Volume 4, Issue 3, Page 684-696, July 2026.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source