Results 81 to 90 of about 7,413 (211)

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

MO622IMPAIRED PROTEIN-BOUND UREMIC TOXIN EXCRETION SUGGESTS TUBULAR DYSFUNCTION IN DIABETIC NEPHROPATHY

Nephrology Dialysis Transplantation, 2021
Abstract Background and Aims Kidney tubular damage is an important prognostic determinant in diabetic nephropathy (DN) (1). Proximal tubular secretion is a vital homeostatic function that is responsible for excretion of waste, such as protein bound uremic toxins (PBUTs) that are minimally eliminated ...
Karin Gerritsen, Sabbir Ahmed, Rolf Sparidans, Silvia Mihaila, Roel Broekhuizen, Roel Goldschmeding, Tri Nguyen, Rosalinde Masereeuw   +7 more
openaire   +1 more source

Complement System Part II: Role in Immunity [PDF]

, 2015
International audienceThe complement system has been considered for a long time as a simple lytic cascade, aimed to kill bacteria infecting the host organism.
Fremeaux-Bacchi, Veronique, Halbwachs-Mecarelli, Lise, Merle, Nicolas S., Noe, Remi, Roumenina, Lubka T.   +4 more
core   +8 more sources

Gut microbiota in chronic kidney disease [PDF]

, 2016
La microflora intestinal mantiene una relación simbiótica con el huésped en condicionesnormales, sin embargo, su alteración se ha asociado recientemente con numerosas enfer-medades.En la enfermedad renal crónica (ERC) se ha descrito una disbiosis en la ...
Cases Amenós, Aleix, Cigarran Guldris, Secundino, González Parra, Emilio   +2 more
core   +3 more sources

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Comparison of uremic toxin removal between expanded hemodialysis and high volume online hemodiafiltrations in different modes

Acta Biochimica Polonica
Various high-efficiency hemodialysis techniques exist, including different online high- volume hemodiafiltration (HDF) modes and expanded hemodialysis (HDx) utilizing dialyzers with medium cut-off (MCO) membranes.
Jan Biedunkiewicz, Agnieszka Zakrzewska, Sylwia Małgorzewicz, Michał Komorniczak, Katarzyna Jasiulewicz, Natalia Płonka, Agnieszka Tarasewicz, Magdalena Jankowska, Bogdan Biedunkiewicz, Alicja Dębska‐Ślizień, Leszek Tylicki   +10 more
doaj   +1 more source

Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2–KEAP1–CUL3 Interactions in Chronic Kidney Disease

Antioxidants, 2020
Chronic kidney disease (CKD) is characterized by the accumulation of protein-bound uremic toxins (PBUTs), which play a pathophysiological role in renal fibrosis (a common pathological process resulting in CKD progression).
Bowen Sun, Xifan Wang, Xiaoxue Liu, Longjiao Wang, Fazheng Ren, Xiaoyu Wang, Xiaojing Leng   +6 more
doaj   +1 more source

Sex steroids do not affect shigatoxin cytotoxicity on human renal tubular or glomerular cells [PDF]

, 2002
Background The greater susceptibility of children to renal injury in post-diarrheal hemolytic-uremic syndrome (HUS) may be related, at least in part, to heightened renal cell sensitivity to the cytotoxic effect of Shiga toxin (Stx), the putative mediator
R Siegler, K Cummings, B Bell, TG Obrig, B Boyd, CA Lingwood, WLM Robson, P van Setten, A Hughes, A Hughes, W Dunagan, K Gunawardena, P van Setten, F Taylor, A Meseguer, M Cid   +15 more
core   +1 more source

Machine learning‐based predictive models versus traditional risk scores in hemodialysis patients with comorbid urolithiasis

Precision Medical Sciences, EarlyView.
Machine learning‐based predictive models outperform traditional risk scores in hemodialysis patients with comorbid urolithiasis by capturing nonlinear, dialysis‐specific interactions. These approaches enable more accurate prediction of stone recurrence, sepsis, hospitalization, and mortality, supporting personalized risk stratification and precision ...
Dipal Chaulagain, Muhammad Riaz, Mirza Muhammad Hadeed Khawar, Jawad Hameed, Malik Sohail Riaz   +4 more
wiley   +1 more source

Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study

Renal Failure
Objective To delineate the efficacy and safety profile of hemodiafiltration with endogenous reinfusion (HFR) for uremic toxin removal in patients undergoing maintenance hemodialysis (MHD).Methods Patients who have been on MHD for a period of at least 3 ...
Renhua Lu, Yan Fang, Wangshu Wu, Xiaojun Zeng, Tingting Liu, Yue Qian, Yuanyuan Xie, Yijun Zhou, Leyi Gu   +8 more
doaj   +1 more source