Protein-bound uremic solutes: The forgotten toxins
Kidney International, 2001 The present concept of dialysis focuses mainly on the removal of small water-soluble compounds, and also, the currently applied kinetic parameters of dialysis adequacy are based on the behavior of water-soluble compounds. Nevertheless, many of the currently known biological effects in uremia are attributable to compounds with different physicochemical ...
Vanholder, Raymond +2 more
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Binding of bromocresol green and bromocresol purple to albumin in hemodialysis patients [PDF]
, 2017 BACKGROUND: Colorimetric albumin assays based on binding to bromocresol purple (BCP) and bromocresol green (BCG) yield different results in chronic kidney disease. Altered dye binding of carbamylated albumin has been suggested as a cause.
Delanghe, Joris +8 more
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Serum levels and removal by haemodialysis and haemodiafiltration of tryptophan-derived uremic toxins in ESKD patients [PDF]
, 2020 Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes.
Adoberg, A +15 more
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Dinucleoside polyphosphates : newly detected uraemic compounds with an impact on leucocyte oxidative burst [PDF]
, 2009 Background. Dinucleoside polyphosphates (NpnN) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells.
Dhondt, Annemieke +5 more
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Biomedicines, 2023 Many hypotheses could explain the mortality decrease observed using hemodiafiltration, such as reduction of intradialytic hypotension and more efficient toxin removal. We led a systematic analysis of representative uremic toxin removal with hemodialysis (
Ariane Duval-Sabatier +10 more
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Does p-cresylglucuronide have the same impact on mortality as other protein-bound uremic toxins? [PDF]
PLoS ONE, 2013 BACKGROUND: Uremic toxins are emerging as important, non-traditional cardiovascular risk factors in chronic kidney disease (CKD). P-cresol has been defined as a prototype protein-bound uremic toxin.
Sophie Liabeuf +9 more
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Effects of uremic toxin p-cresol on oxidative stress in human coronary artery endothelial cells
Di-san junyi daxue xuebao, 2021 Objective To investigate the effects of uremic toxin p-cresol (PC) on the oxidative stress of human coronary artery endothelial cells (HCAECs). Methods HCAECs were cultured in vitro, and treated with different concentrations of free PC alone or combined ...
LI Li, LI Jing, YUAN Fahuan, LI Xiaoli
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Protein-Bound Uremic Toxins Stimulate Crosstalk between Leukocytes and Vessel Wall [PDF]
Journal of the American Society of Nephrology, 2013 Leukocyte activation and endothelial damage both contribute to cardiovascular disease, a major cause of morbidity and mortality in CKD. Experimental in vitro data link several protein-bound uremic retention solutes to the modulation of inflammatory stimuli, including endothelium and leukocyte responses and cardiovascular damage, corroborating ...
Pletinck, A. +13 more
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Uraemic toxins and new methods to control their accumulation : game changers for the concept of dialysis adequacy [PDF]
, 2015 The current concept of an adequate dialysis based only on the dialysis process itself is rather limited. We now have considerable knowledge of uraemic toxicity and improved tools for limiting uraemic toxin accumulation. It is time to make use of these. A
Glorieux, Griet, Tattersall, James
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The intestine and the kidneys : a bad marriage can be hazardous [PDF]
, 2015 The concept that the intestine and chronic kidney disease influence each other, emerged only recently. The problem is multifaceted and bidirectional. On one hand, the composition of the intestinal microbiota impacts uraemic retention solute production ...
Glorieux, Griet, Vanholder, Raymond
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