Protein-bound uremic toxin clearance as biomarker of kidney tubular function in diabetic kidney disease [PDF]
Scientific ReportsKidney tubular damage is an important prognostic determinant in diabetic kidney disease (DKD). A vital homeostatic function of the proximal tubule is active tubular secretion of waste products via organic anion transporters (OATs), including protein ...
Sabbir Ahmed +8 more
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pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro [PDF]
Toxins, 2021 Protein-bound uremic toxins (PBUTs) are difficult to remove using conventional dialysis treatment owing to their high protein-binding affinity. As pH changes the conformation of proteins, it may be associated with the binding of uremic toxins.
Suguru Yamamoto +7 more
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AST-120 to target protein-bound uremic toxins improves cardiac output and kidney oxygenation in experimental chronic kidney disease. [PDF]
Kidney & Blood Pressure Research, 2023 Introduction Chronic kidney disease (CKD) is a global health problem with increasing incidence which is closely associated with cardiac dysfunction. In CKD uremic toxins accumulate as kidney function declines.
Ebba Sivertsson +5 more
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Biomedicines, 2023 Many hypotheses could explain the mortality decrease observed using hemodiafiltration, such as reduction of intradialytic hypotension and more efficient toxin removal. We led a systematic analysis of representative uremic toxin removal with hemodialysis (
Ariane Duval-Sabatier +10 more
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Differences in Dialysis Efficacy Have Limited Effects on Protein-Bound Uremic Toxins Plasma Levels over Time [PDF]
Toxins, 2019 The protein-bound uremic toxins para-cresyl sulfate (pCS) and indoxyl sulfate (IS) are associated with cardiovascular disease in chronic renal failure, but the effect of different dialysis procedures on their plasma levels over time is poorly studied ...
Detlef H. Krieter +4 more
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Cardiotoxicity of Uremic Toxins: A Driver of Cardiorenal Syndrome [PDF]
Toxins, 2018 Cardiovascular disease (CVD) is highly prevalent in the setting of chronic kidney disease (CKD). Such coexistence of CVD and CKD—the so-called “cardiorenal or renocardiac syndrome”—contributes to exponentially increased risk of ...
Suree Lekawanvijit
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Comprehensive Bibliometric Analysis of Uremic Toxin Research [PDF]
ToxinsUremic toxins accumulate as kidney disease progresses, contributing to diverse systemic disorders. Despite numerous studies, no comprehensive mapping has been performed.
Marsuki Hardjo +4 more
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Parallel metabolomic and transcriptomic profiling reveals the cytotoxic mechanism of protein-bound uremic toxin p-cresol sulfate via disruption of glutathione and glycerophospholipid metabolism in MC3T3-E1 osteoblasts [PDF]
BMC NephrologyBackground Chronic kidney disease-mineral bone disorder (CKD-MBD), a common complication of chronic kidney disease (CKD), leads to vascular calcification, osteoporosis, and electrolyte disturbances, impacting patient survival and quality of life ...
Qiong Wu +11 more
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Vascular Incompetence in Dialysis Patients—Protein‐Bound Uremic Toxins and Endothelial Dysfunction [PDF]
Seminars in Dialysis, 2011 AbstractPatients with chronic kidney disease (CKD) have a much higher risk of cardiovascular diseases than the general population. Endothelial dysfunction, which participates in accelerated atherosclerosis, is a hallmark of CKD. Patients with CKD display impaired endothelium‐dependent vasodilatation, elevated soluble biomarkers of endothelial ...
Jourde-Chiche, Noemie +4 more
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Detailing Protein-Bound Uremic Toxin Interaction Mechanisms with Human Serum Albumin in the Pursuit of Designing Competitive Binders. [PDF]
Int J Mol Sci, 2023 Dehghan Niestanak V, Unsworth LD.
europepmc +2 more sources