Displacing the Burden: A Review of Protein-Bound Uremic Toxin Clearance Strategies in Chronic Kidney Disease. [PDF]
J Clin MedUremic toxins (UTs), particularly protein-bound uremic toxins (PBUTs), accumulate in chronic kidney disease (CKD) patients, causing significant health complications like uremic syndrome, cardiovascular disease, and immune dysfunction.
Sánchez-Ospina D +6 more
europepmc +4 more sources
A novel mathematical model of protein-bound uremic toxin kinetics during hemodialysis. [PDF]
Sci Rep, 2017 AbstractProtein-bound uremic toxins (PBUTs) are difficult to remove by conventional hemodialysis; a high degree of protein binding reduces the free fraction of toxins and decreases their diffusion across dialyzer membranes. Mechanistic understanding of PBUT kinetics can open new avenues to improve their dialytic removal.
Maheshwari V +5 more
europepmc +6 more sources
Assessment of Within- and Inter-Patient Variability of Uremic Toxin Concentrations in Children with CKD [PDF]
ToxinsTo promote improved trial design in upcoming randomized clinical trials in childhood chronic kidney disease (CKD), insight in the within- and inter-patient variability of uremic toxins with its nutritional, treatment- and patient-related confounding ...
Evelien Snauwaert +11 more
doaj +7 more sources
Effect of Low Protein Diet Supplemented with Ketoanalogs on Endothelial Function and Protein-Bound Uremic Toxins in Patients with Chronic Kidney Disease [PDF]
Biomedicines, 2023 Studies have demonstrated that a low-protein diet supplemented with ketoanalogs (KAs) could significantly retard progression of renal function in patients with chronic kidney disease (CKD) stages 3–5.
George Chang +4 more
doaj +2 more sources
Does p-cresylglucuronide have the same impact on mortality as other protein-bound uremic toxins? [PDF]
PLoS ONE, 2013 BACKGROUND: Uremic toxins are emerging as important, non-traditional cardiovascular risk factors in chronic kidney disease (CKD). P-cresol has been defined as a prototype protein-bound uremic toxin.
Sophie Liabeuf +9 more
doaj +4 more sources
Optimization of Ibuprofen Route and Dosage to Enhance Protein-Bound Uremic Toxin Clearance During Hemodialysis [PDF]
ToxinsProtein-bound uremic toxins (PBUT), particularly indoxyl sulphate (IS) and p-cresyl sulphate (pCS), are poorly removed by conventional haemodialysis because of their strong albumin binding.
Víctor Joaquín Escudero-Saiz +10 more
doaj +2 more sources
The gut-kidney axis in chronic kidney disease: a vicious cycle of microbial dysbiosis and uremic toxin accumulation [PDF]
Frontiers in ImmunologyThe progression of Chronic Kidney Disease (CKD) is governed by a pathogenic interplay between the host and the gut microbiota, a relationship encapsulated in the gut-kidney axis.
Ruohan Guan +11 more
doaj +2 more sources
Indoxyl Sulfate-Induced Macrophage Toxicity and Therapeutic Strategies in Uremic Atherosclerosis [PDF]
ToxinsCardiovascular disease (CVD) frequently occurs in patients with chronic kidney disease (CKD), particularly those undergoing dialysis. The mechanisms behind this may be related to traditional risk factors and CKD-specific factors that accelerate ...
Takuya Wakamatsu +3 more
doaj +2 more sources
Optical Method and Biochemical Source for the Assessment of the Middle-Molecule Uremic Toxin β2-Microglobulin in Spent Dialysate [PDF]
Toxins, 2021 Optical monitoring of spent dialysate has been used to estimate the removal of water-soluble low molecular weight as well as protein-bound uremic toxins from the blood of end stage kidney disease (ESKD) patients.
Joosep Paats +7 more
doaj +2 more sources
Membrane-to-Patient Optimization: Individualized Dialyzer Selection for Extracorporeal Dialysis [PDF]
ToxinsExtracorporeal dialysis for uremic toxin removal and fluid regulation relies on specialized dialyzers whose membranes differ markedly in polymer chemistry, pore architecture, adsorption capacity, surface bioactivity, and convective performance.
Mariana Murea +6 more
doaj +2 more sources