Results 11 to 20 of about 7,413 (211)
Gut-Derived Protein-Bound Uremic Toxins [PDF]
Toxins, 2020 Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of the fastest growing global causes of mortality. When glomerular filtration rate begins to fall, uremic toxins accumulate in the serum and significantly increase ...
Amanda L. Graboski, Matthew R. Redinbo
doaj +5 more sources
Animal Models for Studying Protein-Bound Uremic Toxin Removal-A Systematic Review. [PDF]
Int J Mol Sci, 2023 Protein-bound uremic toxins (PBUTs) are associated with the progression of chronic kidney disease (CKD) and its associated morbidity and mortality. The conventional dialysis techniques are unable to efficiently remove PBUTs due to their plasma protein binding.
Ahmed S +7 more
europepmc +7 more sources
Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate
Toxins, 2014 Protein binding prevents uremic toxins from removal by conventional extracorporeal therapies leading to accumulation in maintenance dialysis patients. Weakening of the protein binding may enhance the dialytic elimination of these toxins.
Eric Devine +4 more
doaj +3 more sources
The Medium Cut-Off Membrane Does Not Lower Protein-Bound Uremic Toxins
Toxins, 2022 The accumulation of protein-bound uremic toxins (PBUT) is associated with increased cardiovascular outcomes in patients on dialysis. However, the efficacy of PBUT removal for a medium-cutoff (MCO) membrane has not been clarified.
Yang Gyun Kim +8 more
doaj +4 more sources
Toxins, 2014 Chronic kidney disease (CKD) has been considered a major risk factor for cardiovascular diseases. Although great advances have recently been made in the pathophysiology and treatment of cardiovascular diseases, CKD remains a major global health problem ...
Shunsuke Ito, Masayuki Yoshida
doaj +3 more sources
Detailing Protein-Bound Uremic Toxin Interaction Mechanisms with Human Serum Albumin in the Pursuit of Designing Competitive Binders. [PDF]
Int J Mol Sci, 2023 Dehghan Niestanak V, Unsworth LD.
europepmc +2 more sources
A novel mathematical model of protein-bound uremic toxin kinetics during hemodialysis. [PDF]
Sci Rep, 2017 AbstractProtein-bound uremic toxins (PBUTs) are difficult to remove by conventional hemodialysis; a high degree of protein binding reduces the free fraction of toxins and decreases their diffusion across dialyzer membranes. Mechanistic understanding of PBUT kinetics can open new avenues to improve their dialytic removal.
Maheshwari V +5 more
europepmc +4 more sources
Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis
Biomedicines, 2023 Chronic kidney disease (CKD) is a progressive condition of kidney dysfunction due to diverse causes of injury. In healthy kidneys, protein-bound uremic toxins (PBUTs) are cleared from the systemic circulation by proximal tubule cells through the concerted action of plasma membrane transporters that facilitate their urinary excretion, but the endogenous
Yi Yang +2 more
openaire +7 more sources
Biomedicines, 2023 Studies have demonstrated that a low-protein diet supplemented with ketoanalogs (KAs) could significantly retard progression of renal function in patients with chronic kidney disease (CKD) stages 3–5.
George Chang +4 more
doaj +1 more source
Displacing the Burden: A Review of Protein-Bound Uremic Toxin Clearance Strategies in Chronic Kidney Disease. [PDF]
J Clin MedSánchez-Ospina D +6 more
europepmc +2 more sources