Gut-Derived Protein-Bound Uremic Toxins [PDF]
Toxins, 2020 Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of the fastest growing global causes of mortality. When glomerular filtration rate begins to fall, uremic toxins accumulate in the serum and significantly increase ...
Amanda L. Graboski, Matthew R. Redinbo
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Furosemide and Serum Protein-Bound Uremic Toxin Concentrations in Patients With CKD [PDF]
Kidney International ReportsIntroduction: Furosemide is commonly prescribed to patients with chronic kidney disease (CKD) but may impair the kidney’s excretion of protein-bound uremic toxins (PBUTs) via the organic anion transporters 1 and 3 (OAT1 and OAT3).
Margaux Costes-Albrespic +29 more
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Animal Models for Studying Protein-Bound Uremic Toxin Removal-A Systematic Review. [PDF]
Int J Mol Sci, 2023 Protein-bound uremic toxins (PBUTs) are associated with the progression of chronic kidney disease (CKD) and its associated morbidity and mortality. The conventional dialysis techniques are unable to efficiently remove PBUTs due to their plasma protein binding.
Ahmed S +7 more
europepmc +13 more sources
Protein-Bound Uremic Toxin Profiling as a Tool to Optimize Hemodialysis. [PDF]
PLoS ONE, 2016 AIM:We studied various hemodialysis strategies for the removal of protein-bound solutes, which are associated with cardiovascular damage. METHODS:This study included 10 patients on standard (3 x 4 h/week) high-flux hemodialysis.
Sunny Eloot +7 more
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Uremic Toxins and Protein-Bound Therapeutics in AKI and CKD: Up-to-Date Evidence [PDF]
Toxins, 2021 Uremic toxins are defined as harmful metabolites that accumulate in the human body of patients whose renal function declines, especially chronic kidney disease (CKD) patients. Growing evidence demonstrates the deteriorating effect of uremic toxins on CKD
Jia-Huang Chen, Chih-Kang Chiang
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Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate [PDF]
Toxins, 2014 Protein binding prevents uremic toxins from removal by conventional extracorporeal therapies leading to accumulation in maintenance dialysis patients. Weakening of the protein binding may enhance the dialytic elimination of these toxins.
Eric Devine +4 more
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P-Cresylsulfate, the Protein-Bound Uremic Toxin, Increased Endothelial Permeability Partly Mediated by Src-Induced Phosphorylation of VE-Cadherin [PDF]
Toxins, 2020 The goal of our study was to investigate the impact of p-cresylsulfate (PCS) on the barrier integrity in human umbilical vein endothelial cell (HUVEC) monolayers and the renal artery of chronic kidney disease (CKD) patients.
Shih-Chieh Chen +3 more
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Disposition and clinical implications of protein-bound uremic toxins [PDF]
Clinical Science, 2017 In patients with chronic kidney disease (CKD), adequate renal clearance is compromised, resulting in the accumulation of a plethora of uremic solutes. These uremic retention solutes, also named uremic toxins, are a heterogeneous group of organic compounds with intrinsic biological activities, many of which are too large to be filtered and/or are ...
Jansen, J. +4 more
core +8 more sources
Uremic Vascular Calcification: The Pathogenic Roles and Gastrointestinal Decontamination of Uremic Toxins [PDF]
Toxins, 2020 Uremic vascular calcification (VC) commonly occurs during advanced chronic kidney disease (CKD) and significantly increases cardiovascular morbidity and mortality.
Chia-Ter Chao, Shih-Hua Lin
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The Dual Roles of Protein-Bound Solutes as Toxins and Signaling Molecules in Uremia [PDF]
Toxins, 2022 In patients with severe kidney disease, renal clearance is compromised, resulting in the accumulation of a plethora of endogenous waste molecules that cannot be removed by current dialysis techniques, the most often applied treatment.
Rosalinde Masereeuw
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