Results 11 to 20 of about 9,946 (182)

Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology [PDF]

Toxicology in Vitro, 2015
The uremic solutes p-cresyl sulfate (pCS) and p-cresyl glucuronide (pCG) accumulate in patients with chronic kidney disease (CKD), and might contribute to disease progression. Moreover, retention of these solutes may directly be related to renal tubular function.
Mutsaers, H.A., Caetano-Pinto, P., Seegers, A.E., Dankers, A.C.A., van den Broek, P.H.H., Wetzels, J.F.M., van den Brand, J., van den Brand, J., van den Heuvel, B., van den Heuvel, B., Hoenderop, J.G., Wilmer, M.J.G., Masereeuw, R.   +12 more
openaire   +9 more sources

Indoxyl Sulfate, Not P-Cresyl Sulfate, is Associated with Advanced Glycation end Products in Patients on Long-Term Hemodialysis [PDF]

Kidney & Blood Pressure Research, 2015
Background/Aims: Advanced glycation end products (AGEs) are pro-inflammatory and pro-oxidative compounds that play a critical role in endothelial dysfunction and atherosclerosis. Protein-bound uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate (PCS)
Cheng-Jui Lin, Jackson Lin, Chi-Feng Pan, Chih-Kuang Chuang, Hsuan-Liang Liu, Fang-Ju Sun, Tuan-Jen Wang, Han-Hsiang Chen, Chih-Jen Wu   +8 more
doaj   +3 more sources

Serum P-Cresyl Sulfate Levels Correlate with Peripheral Arterial Disease in Hypertensive Patients [PDF]

Diagnostics
Background/Objectives: p-Cresyl sulfate (PCS) is implicated in inflammation, oxidative stress and vascular dysfunction. Hypertension is a major risk factor for peripheral arterial disease (PAD), which is linked to increased mortality in patients with ...
Yahn-Bor Chern, Jen-Pi Tsai, Bang-Gee Hsu, Chin-Hung Liu, Ji-Hung Wang   +4 more
doaj   +2 more sources

Validation of an LC–HRMS Method for Quantifying Indoxyl Sulfate and p-Cresyl Sulfate in Human Serum [PDF]

Molecules
Accurate quantification of indoxyl sulfate (IndS) and p-cresyl sulfate (pCS) is essential for understanding their role in chronic kidney disease (CKD) progression and for developing strategies to mitigate their harmful effects, including cardiovascular ...
María Rodríguez-García, Irene Martínez, Irene Aliart, Jaime I. Sainz de Medrano, Nayra Rico, Víctor Joaquín Escudero-Saiz, Francisco Maduell, Manuel Morales-Ruiz, Gregori Casals   +8 more
doaj   +2 more sources

Association between Protein-Bound Uremic Toxins and Asymptomatic Cardiac Dysfunction in Patients with Chronic Kidney Disease [PDF]

Toxins, 2018
Although the relationship between protein-bound uremic toxins (PBUTs) and cardiac structure and cardiac mortality in chronic kidney disease (CKD) has been studied in the past, the association between cardiac dysfunction and PBUTs has not yet been studied.
Shanmugakumar Chinnappa, Yu-Kang Tu, Yi Chun Yeh, Griet Glorieux, Raymond Vanholder, Andrew Mooney   +5 more
doaj   +3 more sources

p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase [PDF]

Kidney International, 2013
The accumulation of p-cresyl sulfate (PCS), a uremic toxin, is associated with the mortality rate of chronic kidney disease patients; however, the biological functions and the mechanism of its action remain largely unknown. Here we determine whether PCS enhances the production of reactive oxygen species (ROS) in renal tubular cells resulting in ...
Watanabe, Hiroshi, Miyamoto, Yohei, Honda, Daisuke, Tanaka, Hisae, Wu, Qiong, Endo, Masayuki, Noguchi, Tsuyoshi, Kadowaki, Daisuke, Ishima, Yu, Kotani, Shunsuke, Nakajima, Makoto, Kataoka, Keiichiro, Kim-Mitsuyama, Shokei, Tanaka, Motoko, Fukagawa, Masafumi, Otagiri, Masaki, Maruyama, Toru   +16 more
openaire   +4 more sources

Curcumin enhances p-cresyl sulfate-induced cytotoxic effects on renal tubular cells. [PDF]

Int J Med Sci, 2022
Indoxyl sulfate (IS) and p-cresyl sulfate (PCS), protein-bound uremic toxins, can induce oxidative stress and cause renal disease progression. However, the different cytotoxic effects on renal cells between IS and PCS are not stated. Due to uremic toxins are generally found in CKD patients, the mechanisms of uremic toxins-induced renal injury are ...
Wei CW, Wu TK, Wu SC, Chen YL, Pan YR, Chien YC, Wu JY, Yu YL, Yiang GT.   +8 more
europepmc   +3 more sources

P-cresyl sulfate causes mitochondrial hyperfusion in H9C2 cardiomyoblasts. [PDF]

J Cell Mol Med, 2020
AbstractIncreased circulating level of uraemic solute p‐cresyl sulphate (PCS) in patients with chronic kidney disease (CKD) is known to increase myocardial burden relevant to mitochondrial abnormalities. This study aimed at investigating mitochondrial response to PCS in H9C2 cardiomyoblasts.
Huang TH, Yip HK, Sun CK, Chen YL, Yang CC, Lee FY.   +5 more
europepmc   +3 more sources

p-Cresyl Sulfate Predicts Ischemic Stroke among Patients on Hemodialysis: A Prospective Cohort Study. [PDF]

Dis Markers, 2022
Background and Purpose. Hemodialysis patients face a higher risk of ischemic stroke. p-Cresyl sulfate is a typical protein-bound uremic toxin that contributes to chronic kidney disease and cardiovascular disease progression, as well as mortality in hemodialysis patients.
Tan X, Zou J, Xiang F, Zhang P, Shen B, Wang Y, Ding X, Cao X.   +7 more
europepmc   +4 more sources

Contribution of Hypoalbuminemia and Anemia to the Prognostic Value of Plasma p-Cresyl Sulfate and p-Cresyl Glucuronide for Cardiovascular Outcome in Chronic Kidney Disease. [PDF]

J Pers Med, 2022
Free plasma concentrations of protein-bound uremic toxins (PBUTs) may be influenced by serum albumin and hemoglobin. The potential association of serum albumin and hemoglobin with free levels of p-cresyl sulfate (pCS) and p-cresyl glucuronide (pCG) and their predictive value for cardiovascular morbidity and mortality were explored.
Verbeke F, Vanholder R, Van Biesen W, Glorieux G.   +3 more
europepmc   +3 more sources