Contribution of Hypoalbuminemia and Anemia to the Prognostic Value of Plasma p-Cresyl Sulfate and p-Cresyl Glucuronide for Cardiovascular Outcome in Chronic Kidney Disease [PDF]
Journal of Personalized Medicine, 2022 Free plasma concentrations of protein-bound uremic toxins (PBUTs) may be influenced by serum albumin and hemoglobin. The potential association of serum albumin and hemoglobin with free levels of p-cresyl sulfate (pCS) and p-cresyl glucuronide (pCG) and ...
Wim Van Biesen +2 more
exaly +5 more sources
Validation of an LC–HRMS Method for Quantifying Indoxyl Sulfate and p-Cresyl Sulfate in Human Serum [PDF]
MoleculesAccurate quantification of indoxyl sulfate (IndS) and p-cresyl sulfate (pCS) is essential for understanding their role in chronic kidney disease (CKD) progression and for developing strategies to mitigate their harmful effects, including cardiovascular ...
María Rodríguez-García +8 more
doaj +7 more sources
PLoS ONE, 2014 BackgroundIndoxyl sulfate and p-cresyl sulfate are unique microbial co-metabolites. Both co-metabolites have been involved in the pathogenesis of accelerated cardiovascular disease and renal disease progression.
Liesbeth Viaene +8 more
doaj +5 more sources
Indoxyl Sulfate, Not P-Cresyl Sulfate, is Associated with Advanced Glycation end Products in Patients on Long-Term Hemodialysis [PDF]
Kidney & Blood Pressure Research, 2015 Background/Aims: Advanced glycation end products (AGEs) are pro-inflammatory and pro-oxidative compounds that play a critical role in endothelial dysfunction and atherosclerosis. Protein-bound uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate (PCS)
Cheng-Jui Lin +8 more
doaj +5 more sources
Possible Effects of Uremic Toxins p-Cresol, Indoxyl Sulfate, p-Cresyl Sulfate on the Development and Progression of Colon Cancer in Patients With Chronic Renal Failure [PDF]
Genes, 2023 Chronic kidney disease (CKD) induces several systemic effects, including the accumulation and production of uremic toxins responsible for the activation of various harmful processes.
Mariadelina Simeoni +2 more
exaly +3 more sources
The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review. [PDF]
J Am Soc Nephrol, 2014 A growing number of publications supports a biologic effect of the protein-bound uremic retention solutes indoxyl sulfate and p-cresyl sulfate. However, the use of unrealistically high free concentrations of these compounds and/or inappropriately low ...
Vanholder R +4 more
europepmc +5 more sources
Renal clearance and intestinal generation of p-cresyl sulfate and indoxyl sulfate in CKD. [PDF]
Clin J Am Soc Nephrol, 2013 p-Cresyl sulfate and indoxyl sulfate contribute to cardiovascular disease and progression of renal disease. Renal clearance of both solutes mainly depends on tubular secretion, and serum concentrations are widely dispersed for any given stage of CKD ...
Poesen R +10 more
europepmc +6 more sources
Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance. [PDF]
J Am Soc Nephrol, 2019 : Background Protein-bound uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (PCS) have been associated with cardiovascular morbidity and mortality in patients with CKD.
Opdebeeck B +9 more
europepmc +7 more sources
p-Cresyl sulfate promotes insulin resistance associated with CKD. [PDF]
J Am Soc Nephrol, 2013 The mechanisms underlying the insulin resistance that frequently accompanies CKD are poorly understood, but the retention of renally excreted compounds may play a role.
Koppe L +12 more
europepmc +7 more sources
Gut-Microbiota-Metabolite Axis in Early Renal Function Decline. [PDF]
PLoS ONE, 2015 IntroductionSeveral circulating metabolites derived from bacterial protein fermentation have been found to be inversely associated with renal function but the timing and disease severity is unclear.
Clara Barrios +10 more
doaj +3 more sources