Results 31 to 40 of about 25,586,764 (161)

Host–microbial co-metabolites: from biogenesis to immunomodulation and implications for health and disease [PDF]

Frontiers in Immunology
Host–microbial co-metabolites are small bioactive molecules generated through obligatory sequential or complementary enzymatic transformations by both gut microbiota and host tissues, including secondary bile acids, trimethylamine N-oxide (TMAO), indoxyl
Ying Wang, Liangliang Zhao, Ying Zou, Lili Nie   +3 more
doaj   +2 more sources

p-Cresyl Sulfate Predicts Ischemic Stroke among Patients on Hemodialysis: A Prospective Cohort Study. [PDF]

Dis Markers, 2022
Background and Purpose. Hemodialysis patients face a higher risk of ischemic stroke. p-Cresyl sulfate is a typical protein-bound uremic toxin that contributes to chronic kidney disease and cardiovascular disease progression, as well as mortality in hemodialysis patients.
Tan X, Zou J, Xiang F, Zhang P, Shen B, Wang Y, Ding X, Cao X.   +7 more
europepmc   +4 more sources

Role of the ABCG2 transporter in the biodistribution of the food-borne uremic toxin p-cresyl sulfate. [PDF]

Sci Rep
Millán-García A, Álvarez-Fernández L, Velasco-Díez M, Huertas-Álvarez D, López-García Á, de la Fuente Á, Merino G, Blanco-Paniagua E.   +7 more
europepmc   +4 more sources

p-Cresyl Sulfate and Indoxyl Sulfate in Hemodialysis Patients [PDF]

Clinical Journal of the American Society of Nephrology, 2009
Indoxyl sulfate and p-cresyl sulfate are important representatives of the protein-bound uremic retention solutes. Serum levels of p-cresyl sulfate and indoxyl sulfate are linked to cardiovascular outcomes and chronic kidney disease progression, respectively.
Björn K I, Meijers, Henriette, De Loor, Bert, Bammens, Kristin, Verbeke, Yves, Vanrenterghem, Pieter, Evenepoel   +5 more
openaire   +2 more sources

The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial. [PDF]

PLoS ONE, 2016
UNLABELLED:The colonic microbial metabolism is a key contributor to uremic retention solutes accumulating in patients with CKD, relating to adverse outcomes and insulin resistance.
Ruben Poesen, Pieter Evenepoel, Henriette de Loor, Jan A Delcour, Christophe M Courtin, Dirk Kuypers, Patrick Augustijns, Kristin Verbeke, Björn Meijers   +8 more
doaj   +1 more source

Protein-Bound Uremic Toxins Lowering Effect of Sevelamer in Pre-Dialysis Chronic Kidney Disease Patients with Hyperphosphatemia: A Randomized Controlled Trial

Toxins, 2021
P-cresyl sulfate and indoxyl sulfate are strongly associated with cardiovascular events and all-cause mortality in chronic kidney disease (CKD). This randomized controlled trial was conducted to compare the effects between sevelamer and calcium carbonate
Kullaya Takkavatakarn, Pongpratch Puapatanakul, Jeerath Phannajit, Warumphon Sukkumme, Pajaree Chariyavilaskul, Patita Sitticharoenchai, Asada Leelahavanichkul, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong   +10 more
doaj   +1 more source

The Uremic Toxin p-Cresyl Sulfate Is a New Predictor of Major Adverse Cardiovascular Events in Patients with ST-Elevation Myocardial Infarction. [PDF]

Toxins (Basel)
ST-elevation myocardial infarction (STEMI) remains a major health concern despite advances in care. Indoxyl sulfate (IS) and p-cresyl-sulfate (p-CS) are gut-derived uremic toxins linked to higher morbidity and mortality in patients with chronic kidney ...
Raillon LA, Bochaton T, Glorieux G, Guebre-Egziabher F, Soulage CO.   +4 more
europepmc   +2 more sources

The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression [PDF]

Nephrology Dialysis Transplantation, 2011
The fundamental insights into uraemic toxicity have evolved little since publication of the classical monograph by Cushny nearly a century ago [1]. Organic metabolites are still thought to substantially contribute to uremia (albeit urea might not be the culprit), yet evidence unequivocally demonstrating toxicity of any single uraemic constituent is ...
Björn K I, Meijers, Pieter, Evenepoel
openaire   +2 more sources

Pea hull fiber supplementation does not modulate uremic metabolites in adults receiving hemodialysis: a randomized, double-blind, controlled trial

Frontiers in Nutrition, 2023
BackgroundFiber is a potential therapeutic to suppress microbiota-generated uremic molecules. This study aimed to determine if fiber supplementation decreased serum levels of uremic molecules through the modulation of gut microbiota in adults undergoing ...
Asmaa M. N. Fatani, Asmaa M. N. Fatani, Joon Hyuk Suh, Jérémie Auger, Karima M. Alabasi, Karima M. Alabasi, Yu Wang, Mark S. Segal, Mark S. Segal, Wendy J. Dahl   +9 more
doaj   +1 more source

Effects of Sevelamer Hydrochloride on Uremic Toxins Serum Indoxyl Sulfate and P-Cresyl Sulfate in Hemodialysis Patients. [PDF]

J Clin Med Res, 2017
Beside the phosphate binding effect, non-calcium non-aluminum phosphate binder, namely sevelamer hydrochloride (SH), has many other effects in dialysis patients. It can absorb many other compounds, decrease low-density lipoprotein cholesterol (LDL-C) level, and attenuate the progression of vascular calcification; it has been reported to have anti ...
Lin CJ, Pan CF, Chuang CK, Liu HL, Huang SF, Chen HH, Wu CJ.   +6 more
europepmc   +4 more sources