The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression [PDF]
Nephrology Dialysis Transplantation, 2011 The fundamental insights into uraemic toxicity have evolved little since publication of the classical monograph by Cushny nearly a century ago [1]. Organic metabolites are still thought to substantially contribute to uremia (albeit urea might not be the culprit), yet evidence unequivocally demonstrating toxicity of any single uraemic constituent is ...
Björn K I, Meijers, Pieter, Evenepoel
openaire +2 more sources
Effects of Sevelamer Hydrochloride on Uremic Toxins Serum Indoxyl Sulfate and P-Cresyl Sulfate in Hemodialysis Patients. [PDF]
J Clin Med Res, 2017 Beside the phosphate binding effect, non-calcium non-aluminum phosphate binder, namely sevelamer hydrochloride (SH), has many other effects in dialysis patients. It can absorb many other compounds, decrease low-density lipoprotein cholesterol (LDL-C) level, and attenuate the progression of vascular calcification; it has been reported to have anti ...
Lin CJ +6 more
europepmc +4 more sources
Correlation between Saliva Levels and Serum Levels of Free Uremic Toxins in Healthy Volunteers
Toxins, 2023 The objective of the present study was to investigate the putative correlation between the saliva concentration and free serum concentration for 10 uremic toxins (UTs; eight protein-bound solutes: 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF),
Nicolas Fabresse +6 more
doaj +1 more source
Removal of Protein-Bound Uremic Toxins Using Binding Competitors in Hemodialysis: A Narrative Review
Toxins, 2021 Removal of protein-bound uremic toxins (PBUTs) during conventional dialysis is insufficient. PBUTs are associated with comorbidities and mortality in dialysis patients.
Vaibhav Maheshwari +3 more
doaj +1 more source
Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice. [PDF]
Mol Med Rep, 2016 p-cresyl sulfate (PCS) is a protein-bound uremic toxin retained in the blood of patients with chronic kidney disease (CKD) As atherosclerosis is a primary cardiovascular complication for patients with CKD, the aim of the present study was to investigate the mechanisms underlying the aggravation of atherosclerosis by PCS.
Han H +5 more
europepmc +4 more sources
Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients [PDF]
, 2017 Background and aim : Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points.
Delrue, Willem +7 more
core +13 more sources
Measuring serum total and free indoxyl sulfate and p-cresyl sulfate in chronic kidney disease using UPLC-MS/MS. [PDF]
J Food Drug Anal, 2019 Chronic kidney disease (CKD) is a complex disorder that affects multiple organs and increases the risk of cardiovascular complications. CKD affects approximately 12% of the population in Taiwan. Loss of kidney function leads to accumulation of potentially toxic compounds such as indoxyl sulfate (IS) and p-cresyl sulfate (pCS), two protein-bound uremic ...
Lin CN +5 more
europepmc +3 more sources
Nutritional Therapy Modulates Intestinal Microbiota and Reduces Serum Levels of Total and Free Indoxyl Sulfate and P-Cresyl Sulfate in Chronic Kidney Disease (Medika Study). [PDF]
J Clin Med, 2019 Di Iorio BR +12 more
europepmc +2 more sources
MO277: Effect of P-Cresyl Sulfate in Cardiorenal Axis in Mice
Nephrology Dialysis Transplantation, 2022 Abstract BACKGROUND AND AIMS Uremic toxins (UT) are extremely relevant for the understanding of pathologies of the cardiovascular system once kidney and heart have a close relationship and share different functions.
Carlos Alexandre Falconi +5 more
openaire +1 more source
Biomolecules, 2023 Diabetic kidney disease (DKD) is one of the most debilitating complications of type 2 diabetes mellitus (T2DM), as it progresses silently to end-stage renal disease (ESRD). The discovery of novel biomarkers of early DKD becomes acute, as its incidence is
Lavinia Balint +13 more
doaj +1 more source