Results 51 to 60 of about 6,406 (145)

Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice

Frontiers in Endocrinology, 2023
p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine. p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic toxins that correlate positively with chronic kidney disease and diabetes ...
Pernille Baumann Toft, Amanda Marie Vanslette, Kajetan Trošt, Thomas Moritz, Matthew Paul Gillum, Fredrik Bäckhed, Fredrik Bäckhed, Fredrik Bäckhed, Tulika Arora   +8 more
doaj   +1 more source

Protective effect of simvastatin on arterial plaque instability induced by p-cresyl sulfate.

European review for medical and pharmacological sciences, 2018
To study the protective effect of simvastatin on arterial plaque instability induced by p-cresyl sulfate (PCS).Apolipoprotein E (ApoE)-/- mice were selected as objects of this study. All mice were randomly divided into three groups: 1) the control group, 2) the PCS group and 3) the PCS + simvastatin group.
Li, H.-Y., Liu, F., Gao, C., Wang, H.-R.
openaire   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Damage of uremic myocardium by p-cresyl sulfate and the ameliorative effect of Klotho by regulating SIRT6 ubiquitination

Toxicology Letters, 2022
Uremic cardiomyopathy (UCM) is a common complication in patients with chronic kidney disease (CKD) and an important risk factor for death. P-Cresyl sulfate (PCS) is a damaging factor in UCM, and Klotho is a protective factor. However, the molecular mechanisms of Klotho and PCS in UCM and the relationship between PCS and Klotho are unclear.
Cheng, Chen, Caidie, Xie, Yiqing, Xiong, Hanzhang, Wu, Lin, Wu, Jingfeng, Zhu, Changying, Xing, Huijuan, Mao   +7 more
openaire   +2 more sources

Meta-Analysis of the Associations of p-Cresyl Sulfate (PCS) and Indoxyl Sulfate (IS) with Cardiovascular Events and All-Cause Mortality in Patients with Chronic Renal Failure. [PDF]

PLoS ONE, 2015
Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are protein-bound uremic toxins that increase in the sera of patients with chronic kidney disease (CKD), and are not effectively removed by dialysis. The purpose of this meta-analysis was to investigate the
Cheng-Jui Lin, Vincent Wu, Pei-Chen Wu, Chih-Jen Wu   +3 more
doaj   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Investigation of Metabolites in Feces and Plasma Associated with the Number of Piglets Weaned per Sow per Year

Metabolites
Background: Sow reproductive performance is a critical parameter for the productivity of commercial pig farms. Gut microbiota is associated with performance in sow reproduction.
Takamitsu Tsukahara, Hiroto Miura, Takahiro Kawase, Shu Yoshimura, Yoshihiro Mizukami, Yoshihiro Yahara, Kikuto Fukuta, Ryo Inoue   +7 more
doaj   +1 more source

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Serum p -cresyl sulfate predicts cardiovascular disease and mortality in elderly hemodialysis patients

Archives of Medical Science, 2013
Previous studies have shown that serum p-cresyl sulfate (PCS) and indoxyl sulfate (IS) were significantly related to clinical outcomes in patients on hemodialysis (HD). However, evidence for the relationship in elderly HD patients remains scarce. We explore whether the two toxins can predict clinical outcomes in elderly HD patients.Fifty stable HD ...
Lin, Cheng-Jui, Chuang, Chih-Kuang, Jayakumar, Thanasekaran, Liu, Hsuan-Liang, Pan, Chi-Feng, Wang, Tuen-Jen, Chen, Han-Hsiang, Wu, Chih-Jen   +7 more
openaire   +2 more sources

Distal Colon Motor Dysfunction in Mice with Chronic Kidney Disease: Putative Role of Uremic Toxins

Toxins, 2018
Although gastrointestinal complications are a common feature of patients with chronic kidney disease (CKD), the impact of uremia on bowel motility remains poorly understood.
Elsa Hoibian, Nans Florens, Laetitia Koppe, Hubert Vidal, Christophe O. Soulage   +4 more
doaj   +1 more source