Results 51 to 60 of about 25,586,764 (161)
Toxins, 2014 Chronic kidney disease (CKD) has been considered a major risk factor for cardiovascular diseases. Although great advances have recently been made in the pathophysiology and treatment of cardiovascular diseases, CKD remains a major global health problem ...
Shunsuke Ito, Masayuki Yoshida
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Biomedicines, 2023 Studies have demonstrated that a low-protein diet supplemented with ketoanalogs (KAs) could significantly retard progression of renal function in patients with chronic kidney disease (CKD) stages 3–5.
George Chang +4 more
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Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice. [PDF]
Mol Med Rep, 2016 p-cresyl sulfate (PCS) is a protein-bound uremic toxin retained in the blood of patients with chronic kidney disease (CKD) As atherosclerosis is a primary cardiovascular complication for patients with CKD, the aim of the present study was to investigate the mechanisms underlying the aggravation of atherosclerosis by PCS.
Han H +5 more
europepmc +4 more sources
Protein-Bound Uremic Toxins: New Insight from Clinical Studies
Toxins, 2011 The uremic syndrome is attributed to the progressive retention of a large number of compounds which, under normal conditions, are excreted by healthy kidneys. The compounds are called uremic toxins when they interact negatively with biological functions.
Ziad A. Massy +2 more
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Uremic Toxins and Protein-Bound Therapeutics in AKI and CKD: Up-to-Date Evidence
Toxins, 2021 Uremic toxins are defined as harmful metabolites that accumulate in the human body of patients whose renal function declines, especially chronic kidney disease (CKD) patients. Growing evidence demonstrates the deteriorating effect of uremic toxins on CKD
Jia-Huang Chen, Chih-Kang Chiang
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The Medium Cut-Off Membrane Does Not Lower Protein-Bound Uremic Toxins
Toxins, 2022 The accumulation of protein-bound uremic toxins (PBUT) is associated with increased cardiovascular outcomes in patients on dialysis. However, the efficacy of PBUT removal for a medium-cutoff (MCO) membrane has not been clarified.
Yang Gyun Kim +8 more
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Heritability of indoxyl sulfate and p-cresyl sulfate.
, 2014 Values are proportions ± standard error. Indoxyl sulfate and p-cresyl sulfate were log-transformed.h2, heritability.Adjusted for sex, age (linear and squared term), triglycerides, current smoking status, measured creatinine clearance and history of ...
Lutgarde Thijs (511286) +8 more
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Toxins, 2020 High serum levels of microbiota-derived uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate (PCS), are associated with chronic kidney disease (CKD) progression and cardiovascular complications.
Maria Teresa Rocchetti +10 more
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Frontiers in Endocrinology, 2023 p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine. p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic toxins that correlate positively with chronic kidney disease and diabetes ...
Pernille Baumann Toft +8 more
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Indoxyl sulfate and p-cresyl sulfate according to age.
, 2014 The dots indicate the geometric means of indoxyl sulfate (IndS) and p-cresyl sulfate (PCS) in decades of age (
Lutgarde Thijs (511286) +8 more
core +1 more source