Results 61 to 70 of about 9,946 (182)

Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice

Frontiers in Endocrinology, 2023
p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine. p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic toxins that correlate positively with chronic kidney disease and diabetes ...
Pernille Baumann Toft, Amanda Marie Vanslette, Kajetan Trošt, Thomas Moritz, Matthew Paul Gillum, Fredrik Bäckhed, Fredrik Bäckhed, Fredrik Bäckhed, Tulika Arora   +8 more
doaj   +1 more source

Efficacy of Divinylbenzenic Resin in Removing Indoxyl Sulfate and P-cresol Sulfate in Hemodialysis Patients: Results from an In Vitro Study and an In Vivo Pilot Trial (xuanro4-Nature 3.2)

Toxins, 2020
High serum levels of microbiota-derived uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate (PCS), are associated with chronic kidney disease (CKD) progression and cardiovascular complications.
Maria Teresa Rocchetti, Carmela Cosola, Ighli di Bari, Stefania Magnani, Vanessa Galleggiante, Letizia Scandiffio, Giuseppe Dalfino, Giuseppe Stefano Netti, Mauro Atti, Roberto Corciulo, Loreto Gesualdo   +10 more
doaj   +1 more source

Microbial−mammalian cometabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American populations [PDF]

, 2013
Understanding the metabolic processes associated with aging is key to developing effective management and treatment strategies for age-related diseases. We investigated the metabolic profiles associated with age in a Taiwanese and an American population.
Beckonert O., Bell J. D., Cannon J. G., Carmel R., Carol D. Ryff, Chadeau-Hyam M., Cho S., Christopher L. Coe, Clarke R., Coe C. L., Dana A. Glei, Davies K. M., Dean M., Elaine Holmes, Elsden S. R., Fukushima T., Goldman N., Hammar M. L., He F., Hebuterne X., Hehemann J. H., Holmes E., Hopkins M. J., Houtkooper R. H., Hurley B. F., Jeremy K. Nicholson, Jonathan R. Swann, Kaiser L. G., Kochhar S., Konstantina Spagou, Laidlaw S. A., Mariat D., Marmot M. G., Matthew Lewis, Maxine Weinstein, Mishur R. J., Muangpaisan W., Nicholson J. K., Noreen Goldman, Okuda Y., O’Sullivan O., Partridge L., Perrone R. D., Piper M. D., Psihogios N. G., Ramakrishna B. S., Ramakrishna B. S., Regitz-Zagrosek V., Robert L., Saude E. J., Slupsky C. M., Stanley E. G., Takiyama N., Teresa E. Seeman, Tiihonen K., Triantafyllou K., van den Bussche H., Veselkov K. A., Veselkov K. A., Vukovich M. D., Wald A., Walston J., Wang Y., Wang Z., Want E. J., Welshman S. G., Wijeyesekera A., Willets J. M., Williams A., Wolfe R. R., Yap I. K., Yasuda M., Zhang A. Q., Zhang F.   +73 more
core   +1 more source

Protective effect of simvastatin on arterial plaque instability induced by p-cresyl sulfate.

European review for medical and pharmacological sciences, 2018
To study the protective effect of simvastatin on arterial plaque instability induced by p-cresyl sulfate (PCS).Apolipoprotein E (ApoE)-/- mice were selected as objects of this study. All mice were randomly divided into three groups: 1) the control group, 2) the PCS group and 3) the PCS + simvastatin group.
Li, H.-Y., Liu, F., Gao, C., Wang, H.-R.
openaire   +2 more sources

Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure [PDF]

, 2015
Chronic kidney disease (CKD) is a major health problem worldwide. Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are highly protein-bound nephro-cardiovascular toxins, which are not efficiently removed through hemodialysis.
Chao, Pei-Dawn Lee, Hou, Yu-Chi, Lin, Shiuan-Pey, Peng, Yu-Hsuan, Sweet, Douglas H., Yu, Chung-Ping   +5 more
core   +2 more sources

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

Meta-Analysis of the Associations of p-Cresyl Sulfate (PCS) and Indoxyl Sulfate (IS) with Cardiovascular Events and All-Cause Mortality in Patients with Chronic Renal Failure. [PDF]

PLoS ONE, 2015
Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are protein-bound uremic toxins that increase in the sera of patients with chronic kidney disease (CKD), and are not effectively removed by dialysis. The purpose of this meta-analysis was to investigate the
Cheng-Jui Lin, Vincent Wu, Pei-Chen Wu, Chih-Jen Wu   +3 more
doaj   +1 more source

Gut microbiota in chronic kidney disease [PDF]

, 2016
La microflora intestinal mantiene una relación simbiótica con el huésped en condicionesnormales, sin embargo, su alteración se ha asociado recientemente con numerosas enfer-medades.En la enfermedad renal crónica (ERC) se ha descrito una disbiosis en la ...
Cases Amenós, Aleix, Cigarran Guldris, Secundino, González Parra, Emilio   +2 more
core   +3 more sources

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Trehalose alleviates the phenotype of Machado–Joseph disease mouse models [PDF]

, 2020
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration.
Cavadas, Cláudia, Cunha-Santos, Janete, Gaspar, Laetitia S., Greif, Hagar, Nobre, Rui Jorge, Nóbrega, Clévio, Paixão, Susana, Pereira de Almeida, Luís, Santana, Magda M., Silva, Teresa Pereira, Trevino-Garcia, Allyson   +10 more
core   +1 more source