Results 61 to 70 of about 25,586,764 (161)

Protective effect of simvastatin on arterial plaque instability induced by p-cresyl sulfate.

European review for medical and pharmacological sciences, 2018
To study the protective effect of simvastatin on arterial plaque instability induced by p-cresyl sulfate (PCS).Apolipoprotein E (ApoE)-/- mice were selected as objects of this study. All mice were randomly divided into three groups: 1) the control group, 2) the PCS group and 3) the PCS + simvastatin group.
Li, H.-Y., Liu, F., Gao, C., Wang, H.-R.
openaire   +2 more sources

Damage of uremic myocardium by p-cresyl sulfate and the ameliorative effect of Klotho by regulating SIRT6 ubiquitination

Toxicology Letters, 2022
Uremic cardiomyopathy (UCM) is a common complication in patients with chronic kidney disease (CKD) and an important risk factor for death. P-Cresyl sulfate (PCS) is a damaging factor in UCM, and Klotho is a protective factor. However, the molecular mechanisms of Klotho and PCS in UCM and the relationship between PCS and Klotho are unclear.
Cheng, Chen, Caidie, Xie, Yiqing, Xiong, Hanzhang, Wu, Lin, Wu, Jingfeng, Zhu, Changying, Xing, Huijuan, Mao   +7 more
openaire   +2 more sources

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets

Journal of Anatomy, EarlyView.
We introduce the MacBrain Resource Center (MBRC) Collections of rhesus macaque embryonic brain tissue. Here, we illustrate histo‐ and immunohistology from our dynamically growing Collection 6, which currently contains >10,000 zoomable and downloadable images from n = 14 male and female embryos from early to late in gestation.
Valeria Mendoza‐Silva, Emma Burke, Lucy Greene, Mikhail Rodov, Janja Kopić, Phil Barello, Yury M. Morozov, Keiko Moriya‐Ito, Chiaki Ohtaka‐Maruyama, Zeljka Krsnik, Pasko Rakic, Alvaro Duque   +11 more
wiley   +1 more source

Investigation of Metabolites in Feces and Plasma Associated with the Number of Piglets Weaned per Sow per Year

Metabolites
Background: Sow reproductive performance is a critical parameter for the productivity of commercial pig farms. Gut microbiota is associated with performance in sow reproduction.
Takamitsu Tsukahara, Hiroto Miura, Takahiro Kawase, Shu Yoshimura, Yoshihiro Mizukami, Yoshihiro Yahara, Kikuto Fukuta, Ryo Inoue   +7 more
doaj   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories

Journal of Anatomy, EarlyView.
The MacBrain Resource Center (MBRC) postnatal rhesus macaque brain histology datasets are organized into Collections that promote cost‐effective de novo research. This article provides examples from Collections 5, 6, and 7 and describes the histo‐ and immunohistochemical (IHC) processing of materials for Collection 6.
Valeria Mendoza‐Silva, Lucy Greene, Emma Burke, Cristina Canales, Julia Chocarro, Jose L. Lanciego, Khuleshwari Kurrey, Phil Barello, Aya Nusir, Nadine Kabbani, Kathleen S. Rockland, Dibyadeep Datta, Jon I. Arellano, Amy F. T. Arnsten, Yury M. Morozov, Bashir Ahmed, Zoltán Molnár, Caroline J. Zeiss, Pasko Rakic, Alvaro Duque   +19 more
wiley   +1 more source

Determination of the binding properties of p -cresyl glucuronide to human serum albumin

, 2018
International audiencep-Cresyl glucuronide (p-CG) is a by-product of tyrosine metabolism that accumulates in patients with end-stage renal disease. p-CG binding to human serum albumin in physiological conditions (37 degrees C, pH 7.40) was studied by ...
Daleprane, Julio B., Elisa Bernardes Monteiro, Soulage, Christophe, Christophe O. Soulage, Stéphane Chambert, Monteiro, Elisa Bernardes, Julio B. Daleprane, Dan Yi, Hédi A. Soula, Yi, Dan, Chambert, Stéphane, Soula, Hédi A.   +11 more
core   +1 more source

Serum p -cresyl sulfate predicts cardiovascular disease and mortality in elderly hemodialysis patients

Archives of Medical Science, 2013
Previous studies have shown that serum p-cresyl sulfate (PCS) and indoxyl sulfate (IS) were significantly related to clinical outcomes in patients on hemodialysis (HD). However, evidence for the relationship in elderly HD patients remains scarce. We explore whether the two toxins can predict clinical outcomes in elderly HD patients.Fifty stable HD ...
Lin, Cheng-Jui, Chuang, Chih-Kuang, Jayakumar, Thanasekaran, Liu, Hsuan-Liang, Pan, Chi-Feng, Wang, Tuen-Jen, Chen, Han-Hsiang, Wu, Chih-Jen   +7 more
openaire   +2 more sources

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin [PDF]

Nephrology Dialysis Transplantation, 2009
Protein-bound uraemic retention solutes, including p-cresyl sulfate and indoxyl sulfate, contribute substantially to the uraemic syndrome. These and several other uraemic retention solutes originate from intestinal bacterial protein fermentation. We investigated whether the prebiotic oligofructose-enriched inulin reduced serum concentration of p-cresyl
Björn K I, Meijers, Vicky, De Preter, Kristin, Verbeke, Yves, Vanrenterghem, Pieter, Evenepoel   +4 more
openaire   +2 more sources