Results 21 to 30 of about 9,946 (182)

Possible Effects of Uremic Toxins p-Cresol, Indoxyl Sulfate, p-Cresyl Sulfate on the Development and Progression of Colon Cancer in Patients with Chronic Renal Failure. [PDF]

Genes (Basel), 2023
Di Paola R, De A, Izhar R, Abate M, Zappavigna S, Capasso A, Perna AF, La Russa A, Capasso G, Caraglia M, Simeoni M.   +10 more
europepmc   +2 more sources

Prebiotics improve metabolic parameter in uremic mice by reducing intestinal production of p-cresyl sulfate

Kidney Research and Clinical Practice, 2012
Chronic kidney disease (CKD) is associated with a large range of metabolic alterations. P-cresyl sulfate (PCS) has been identified as one of the main uremic toxins involved in the pathogenesis of accelerated atherosclerosis in CKD.
Laetitia Koppe, Caroline Pelletier, Denis Fouque, Christophe Soulage   +3 more
doaj   +2 more sources

Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance. [PDF]

J Am Soc Nephrol, 2019
Significance Statement Vascular calcification contributes to high cardiovascular mortality in patients with CKD. Although research findings have suggested an association between the uremic toxins indoxyl sulfate and p-cresyl sulfate and cardiovascular disease, direct evidence has been lacking.
Opdebeeck B, Maudsley S, Azmi A, De Maré A, De Leger W, Meijers B, Verhulst A, Evenepoel P, D'Haese PC, Neven E.   +9 more
europepmc   +4 more sources

The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review. [PDF]

J Am Soc Nephrol, 2014
A growing number of publications supports a biologic effect of the protein-bound uremic retention solutes indoxyl sulfate and p-cresyl sulfate. However, the use of unrealistically high free concentrations of these compounds and/or inappropriately low albumin concentrations may blur the interpretation of these results.
Vanholder R, Schepers E, Pletinck A, Nagler EV, Glorieux G.   +4 more
europepmc   +4 more sources

p-Cresyl sulfate promotes insulin resistance associated with CKD. [PDF]

J Am Soc Nephrol, 2013
The mechanisms underlying the insulin resistance that frequently accompanies CKD are poorly understood, but the retention of renally excreted compounds may play a role. One such compound is p-cresyl sulfate (PCS), a protein-bound uremic toxin that originates from tyrosine metabolism by intestinal microbes.
Koppe L, Pillon NJ, Vella RE, Croze ML, Pelletier CC, Chambert S, Massy Z, Glorieux G, Vanholder R, Dugenet Y, Soula HA, Fouque D, Soulage CO.   +12 more
europepmc   +6 more sources

The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial. [PDF]

PLoS ONE, 2016
UNLABELLED:The colonic microbial metabolism is a key contributor to uremic retention solutes accumulating in patients with CKD, relating to adverse outcomes and insulin resistance.
Ruben Poesen, Pieter Evenepoel, Henriette de Loor, Jan A Delcour, Christophe M Courtin, Dirk Kuypers, Patrick Augustijns, Kristin Verbeke, Björn Meijers   +8 more
doaj   +1 more source

Protein-Bound Uremic Toxins Lowering Effect of Sevelamer in Pre-Dialysis Chronic Kidney Disease Patients with Hyperphosphatemia: A Randomized Controlled Trial

Toxins, 2021
P-cresyl sulfate and indoxyl sulfate are strongly associated with cardiovascular events and all-cause mortality in chronic kidney disease (CKD). This randomized controlled trial was conducted to compare the effects between sevelamer and calcium carbonate
Kullaya Takkavatakarn, Pongpratch Puapatanakul, Jeerath Phannajit, Warumphon Sukkumme, Pajaree Chariyavilaskul, Patita Sitticharoenchai, Asada Leelahavanichkul, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong   +10 more
doaj   +1 more source

Pea hull fiber supplementation does not modulate uremic metabolites in adults receiving hemodialysis: a randomized, double-blind, controlled trial

Frontiers in Nutrition, 2023
BackgroundFiber is a potential therapeutic to suppress microbiota-generated uremic molecules. This study aimed to determine if fiber supplementation decreased serum levels of uremic molecules through the modulation of gut microbiota in adults undergoing ...
Asmaa M. N. Fatani, Asmaa M. N. Fatani, Joon Hyuk Suh, Jérémie Auger, Karima M. Alabasi, Karima M. Alabasi, Yu Wang, Mark S. Segal, Mark S. Segal, Wendy J. Dahl   +9 more
doaj   +1 more source

Renal clearance and intestinal generation of p-cresyl sulfate and indoxyl sulfate in CKD. [PDF]

Clin J Am Soc Nephrol, 2013
Summary Background and objectives p-Cresyl sulfate and indoxyl sulfate contribute to cardiovascular disease and progression of renal disease. Renal clearance of both solutes mainly depends on tubular secretion, and serum concentrations are widely dispersed for any given stage of CKD ...
Poesen R, Viaene L, Verbeke K, Claes K, Bammens B, Sprangers B, Naesens M, Vanrenterghem Y, Kuypers D, Evenepoel P, Meijers B.   +10 more
europepmc   +5 more sources

p-Cresyl sulfate and indoxyl sulfate in hemodialysis patients. [PDF]

Clin J Am Soc Nephrol, 2009
Indoxyl sulfate and p-cresyl sulfate are important representatives of the protein-bound uremic retention solutes. Serum levels of p-cresyl sulfate and indoxyl sulfate are linked to cardiovascular outcomes and chronic kidney disease progression, respectively.
Meijers BK, De Loor H, Bammens B, Verbeke K, Vanrenterghem Y, Evenepoel P.   +5 more
europepmc   +4 more sources