The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review. [PDF]
J Am Soc Nephrol, 2014 A growing number of publications supports a biologic effect of the protein-bound uremic retention solutes indoxyl sulfate and p-cresyl sulfate. However, the use of unrealistically high free concentrations of these compounds and/or inappropriately low albumin concentrations may blur the interpretation of these results.
Vanholder R +4 more
europepmc +4 more sources
Role of the ABCG2 transporter in the biodistribution of the food-borne uremic toxin p-cresyl sulfate. [PDF]
Sci RepMillán-García A +7 more
europepmc +4 more sources
p-Cresyl Sulfate and Indoxyl Sulfate in Hemodialysis Patients [PDF]
Clinical Journal of the American Society of Nephrology, 2009 Indoxyl sulfate and p-cresyl sulfate are important representatives of the protein-bound uremic retention solutes. Serum levels of p-cresyl sulfate and indoxyl sulfate are linked to cardiovascular outcomes and chronic kidney disease progression, respectively.
Björn K I, Meijers +5 more
openaire +2 more sources
The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial. [PDF]
PLoS ONE, 2016 UNLABELLED:The colonic microbial metabolism is a key contributor to uremic retention solutes accumulating in patients with CKD, relating to adverse outcomes and insulin resistance.
Ruben Poesen +8 more
doaj +1 more source
Toxins, 2021 P-cresyl sulfate and indoxyl sulfate are strongly associated with cardiovascular events and all-cause mortality in chronic kidney disease (CKD). This randomized controlled trial was conducted to compare the effects between sevelamer and calcium carbonate
Kullaya Takkavatakarn +10 more
doaj +1 more source
The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression [PDF]
Nephrology Dialysis Transplantation, 2011 The fundamental insights into uraemic toxicity have evolved little since publication of the classical monograph by Cushny nearly a century ago [1]. Organic metabolites are still thought to substantially contribute to uremia (albeit urea might not be the culprit), yet evidence unequivocally demonstrating toxicity of any single uraemic constituent is ...
Björn K I, Meijers, Pieter, Evenepoel
openaire +2 more sources
Frontiers in Nutrition, 2023 BackgroundFiber is a potential therapeutic to suppress microbiota-generated uremic molecules. This study aimed to determine if fiber supplementation decreased serum levels of uremic molecules through the modulation of gut microbiota in adults undergoing ...
Asmaa M. N. Fatani +9 more
doaj +1 more source
p-Cresyl sulfate promotes insulin resistance associated with CKD. [PDF]
J Am Soc Nephrol, 2013 The mechanisms underlying the insulin resistance that frequently accompanies CKD are poorly understood, but the retention of renally excreted compounds may play a role. One such compound is p-cresyl sulfate (PCS), a protein-bound uremic toxin that originates from tyrosine metabolism by intestinal microbes.
Koppe L +12 more
europepmc +6 more sources
Renal clearance and intestinal generation of p-cresyl sulfate and indoxyl sulfate in CKD. [PDF]
Clin J Am Soc Nephrol, 2013 Summary Background and objectives p-Cresyl sulfate and indoxyl sulfate contribute to cardiovascular disease and progression of renal disease. Renal clearance of both solutes mainly depends on tubular secretion, and serum concentrations are widely dispersed for any given stage of CKD ...
Poesen R +10 more
europepmc +5 more sources
Nutritional Therapy Modulates Intestinal Microbiota and Reduces Serum Levels of Total and Free Indoxyl Sulfate and P-Cresyl Sulfate in Chronic Kidney Disease (Medika Study) [PDF]
Journal of Clinical Medicine, 2019 Antonio Bellasi +2 more
exaly +2 more sources