-Cresyl sulfate and indoxyl sulfate in pediatric patients on chronic dialysis [PDF]
Korean Journal of Pediatrics, 2013 PurposeIndoxyl sulfate and p-cresyl sulfate are important protein-bound uremic retention solutes whose levels can be partially reduced by renal replacement therapy. These solutes originate from intestinal bacterial protein fermentation and are associated
Hye Sun Hyun +2 more
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-Derived p-Cresyl Metabolites Induce Inflammation and Apoptosis in Biliary Epithelial Cells [PDF]
Cancer InformaticsObjective Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease, and the effects of p-cresyl sulfate (PCS) and p-cresyl glucuronide (PCG) in PBC remain unclear.
Haiyan Yu +7 more
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Meta-Analysis of the Associations of p-Cresyl Sulfate (PCS) and Indoxyl Sulfate (IS) with Cardiovascular Events and All-Cause Mortality in Patients with Chronic Renal Failure. [PDF]
PLoS ONE, 2015 Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are protein-bound uremic toxins that increase in the sera of patients with chronic kidney disease (CKD), and are not effectively removed by dialysis. The purpose of this meta-analysis was to investigate the
Cheng-Jui Lin +3 more
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Serum P-Cresyl Sulfate Is a Predictor of Central Arterial Stiffness in Patients on Maintenance Hemodialysis. [PDF]
Toxins (Basel), 2019 Arterial stiffness (AS) has an important impact on the outcomes of patients on hemodialysis (HD), and p-cresyl sulfate (PC) can mediate the process of vascular damage.
Lai YH +5 more
europepmc +5 more sources
Journal of Renal Nutrition, 2014 International audienceProtein-bound uremic toxins (i.e., indoxyl sulfate or p-cresyl sulfate), produced by intestinal bacteria, are accumulated in the plasma of chronic kidney disease (CKD) patients.
Stockler-Pinto, M. B. +4 more
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Distal Colon Motor Dysfunction in Mice with Chronic Kidney Disease: Putative Role of Uremic Toxins
Toxins, 2018 Although gastrointestinal complications are a common feature of patients with chronic kidney disease (CKD), the impact of uremia on bowel motility remains poorly understood.
Elsa Hoibian +4 more
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P-cresyl sulfate causes mitochondrial hyperfusion in H9C2 cardiomyoblasts. [PDF]
J Cell Mol Med, 2020 AbstractIncreased circulating level of uraemic solute pâcresyl sulphate (PCS) in patients with chronic kidney disease (CKD) is known to increase myocardial burden relevant to mitochondrial abnormalities. This study aimed at investigating mitochondrial response to PCS in H9C2 cardiomyoblasts.
Huang TH +5 more
europepmc +3 more sources
Curcumin enhances p-cresyl sulfate-induced cytotoxic effects on renal tubular cells. [PDF]
Int J Med Sci, 2022 Indoxyl sulfate (IS) and p-cresyl sulfate (PCS), protein-bound uremic toxins, can induce oxidative stress and cause renal disease progression. However, the different cytotoxic effects on renal cells between IS and PCS are not stated. Due to uremic toxins are generally found in CKD patients, the mechanisms of uremic toxins-induced renal injury are ...
Wei CW +8 more
europepmc +3 more sources
Improving the In Vitro Removal of Indoxyl Sulfate and p-Cresyl Sulfate by Coating Diatomaceous Earth (DE) and Poly-vinyl-pyrrolidone-co-styrene (PVP-co-S) with Polydopamine. [PDF]
Toxins (Basel), 2022 Polydopamine (PDA) is a synthetic eumelanin polymer mimicking the biopolymer secreted by mussels to attach to surfaces with a high binding strength.
Cicco SR +9 more
europepmc +2 more sources
Kidney Research and Clinical Practice, 2012 Chronic kidney disease (CKD) is associated with a large range of metabolic alterations. P-cresyl sulfate (PCS) has been identified as one of the main uremic toxins involved in the pathogenesis of accelerated atherosclerosis in CKD.
Laetitia Koppe +3 more
doaj +2 more sources