Results 41 to 50 of about 7,345 (172)
Indoxyl-Sulfate-Induced Redox Imbalance in Chronic Kidney Disease [PDF]
Antioxidants, 2021 The accumulation of the uremic toxin indoxyl sulfate (IS) induces target organ damage in chronic kidney disease (CKD) patients, and causes complications including cardiovascular diseases, renal osteodystrophy, muscle wasting, and anemia. IS stimulates reactive oxygen species (ROS) production in CKD, which impairs glomerular filtration by a direct ...
Chien-Lin Lu +5 more
openaire +3 more sources
Indoxyl sulfate in hemodialysis patients
Journal of Japanese Society for Dialysis Therapy, 1988 慢性血液透析患者血液中に蛋白結合して著明に増加しているインドキシル硫酸の高速液体クロマトグラフィー (HPLC) を用いた簡便な定量法の確立を試みた. 血清10μlをinternal-surface reversed-phase (ISRP) カラムを装着したHPLCにより分析した. 溶出ピークを乾固後, 二次イオンマススペクトロメトリー (SIMS) により測定したところ, 分子量が213と分かり, また, UVスペクトル, HPLCの保持時間もインドキシル硫酸と一致した.
Niwa, Toshimitsu +3 more
openaire +2 more sources
Indoxyl sulfate induces apoptosis in mononuclear blood cells via mitochondrial pathway
Scientific Reports, 2023 The consequence of chronic kidney disease is the accumulation of metabolic products called uremic toxins in the body. Indoxyl sulfate (IS) is a toxin with a high affinity for proteins.
Anna Pieniazek +2 more
doaj +1 more source
Toxins, 2021 P-cresyl sulfate and indoxyl sulfate are strongly associated with cardiovascular events and all-cause mortality in chronic kidney disease (CKD). This randomized controlled trial was conducted to compare the effects between sevelamer and calcium carbonate
Kullaya Takkavatakarn +10 more
doaj +1 more source
Neurobehavioral effects of uremic toxin–indoxyl sulfate in the rat model [PDF]
Scientific Reports, 2020 AbstractChronic kidney disease (CKD) is deemed to be a worldwide health concern connected with neurological manifestations. The etiology of central nervous system (CNS) disorders in CKD is still not fully understood, however particular attention is currently being paid to the impact of accumulated toxins.
Karbowska, Małgorzata +7 more
openaire +2 more sources
Gut-Microbiota-Metabolite Axis in Early Renal Function Decline.
PLoS ONE, 2015 IntroductionSeveral circulating metabolites derived from bacterial protein fermentation have been found to be inversely associated with renal function but the timing and disease severity is unclear.
Clara Barrios +10 more
doaj +1 more source
The Effects of Indoxyl Sulfate on Human Umbilical Cord-Derived Mesenchymal Stem Cells In Vitro
Cellular Physiology and Biochemistry, 2016 Background/Aims: Indoxyl sulfate, an important protein-bound uremic toxin, can damage stem cells, thus hampering stem cell-based regenerative medicine approaches targeting chronic kidney diseases (CKD). Human umbilical cord-derived mesenchymal stem cells
Wei Wang +9 more
doaj +1 more source
Phytotherapy Research, EarlyView.Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen +10 more
wiley +1 more source
Association between Dental Scores and Saliva Uremic Toxins
Toxins, 2023 Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins ...
Claire Rigothier +8 more
doaj +1 more source
Toxins, 2014 Chronic kidney disease (CKD) has been considered a major risk factor for cardiovascular diseases. Although great advances have recently been made in the pathophysiology and treatment of cardiovascular diseases, CKD remains a major global health problem ...
Shunsuke Ito, Masayuki Yoshida
doaj +1 more source