Results 11 to 20 of about 15,787 (202)

Gut-Derived Protein-Bound Uremic Toxins

Toxins, 2020
Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of the fastest growing global causes of mortality. When glomerular filtration rate begins to fall, uremic toxins accumulate in the serum and significantly increase ...
Amanda Graboski, Matthew Redinbo, Redinbo Matthew R   +2 more
exaly   +3 more sources

Vascular inflammation in chronic kidney disease: the role of uremic toxins in macrophage activation [PDF]

Frontiers in Cardiovascular Medicine
Chronic kidney disease (CKD) is a progressive condition characterized by the gradual loss of kidney function, leading to the accumulation of uremic toxins in the bloodstream.
Prabhash Kumar Jha, Toshiaki Nakano, Toshiaki Nakano, Lucas Yuji Umesaki Itto, Miguel Cantadori Barbeiro, Adrien Lupieri, Elena Aikawa, Elena Aikawa, Masanori Aikawa, Masanori Aikawa, Masanori Aikawa   +10 more
doaj   +2 more sources

The Impact of CKD on Uremic Toxins and Gut Microbiota

Toxins, 2021
Numerous studies have indicated that the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD) is strictly associated with the accumulation of toxic metabolites in blood and other metabolic compartments.
Jacek Rysz, Robert Olszewski, Anna Gluba-Sagr   +2 more
exaly   +3 more sources

Tryptophan-Derived Uremic Toxins and Thrombosis in Chronic Kidney Disease

Toxins, 2018
Patients with chronic kidney disease (CKD) display an elevated risk of thrombosis. Thrombosis occurs in cardiovascular events, such as venous thromboembolism, stroke, and acute coronary syndrome, and is a cause of hemodialysis vascular access dysfunction.
Laetitia Dou, Stéphane Burtey, Burtey Stéphane   +2 more
exaly   +3 more sources

Development of a convenient and rapid screening zebrafish model to investigate lethal effects and immunocompromised states of uremic toxins [PDF]

Renal Failure
Background Uremia is characterized by high mortality and immune dysfunction owing to the accumulation of uremic toxins. Traditional rodent models are complex and time consuming.
Pema Jo, Rui Zhang, Yuhua Zhang, Zhilian Li, Yanhua Wu, Shuqiong Zhang, Tsring Lhamo, Yuanhan Chen   +7 more
doaj   +2 more sources

Future of Uremic Toxin Management

Toxins
During the progression of chronic kidney disease (CKD), the retention of uremic toxins plays a key role in the development of uremic syndrome. Knowledge about the nature and biological impact of uremic toxins has grown exponentially over the past decades.
Raymond Vanholder, Evelien Snauwaert, Francis Verbeke, Griet Glorieux   +3 more
doaj   +4 more sources

Uremic Toxins and Cardiovascular System [PDF]

Cardiology Clinics, 2021
When chronic kidney disease develops, the capacity of the kidneys to clear metabolic waste products from the body is gradually lost. This process results in the retention of a large array of compounds affecting biochemical and biological functions (uremic toxins), of which several can cause cardiovascular damage.
Valkenburg, Sophie, Glorieux, Griet, Vanholder, Raymond   +2 more
openaire   +3 more sources

Uremic Toxins and Protein-Bound Therapeutics in AKI and CKD: Up-to-Date Evidence

Toxins, 2021
Uremic toxins are defined as harmful metabolites that accumulate in the human body of patients whose renal function declines, especially chronic kidney disease (CKD) patients. Growing evidence demonstrates the deteriorating effect of uremic toxins on CKD
Jia-Huang Chen, Chih-Kang Chiang
doaj   +1 more source

The removal of uremic toxins [PDF]

Kidney International, 2000
Three major groups of uremic solutes can be characterized: the small water-soluble compounds, the middle molecules, and the protein-bound compounds. Whereas small water-soluble compounds are quite easily removed by conventional hemodialysis, this is not the case for many other molecules with different physicochemical characteristics.
Dhondt, Annemieke, Vanholder, Raymond, Van Biesen, Wim, Lameire, Norbert   +3 more
openaire   +2 more sources

Lipid Profile Is Negatively Associated with Uremic Toxins in Patients with Kidney Failure—A Tri-National Cohort

Toxins, 2022
Patients with kidney failure (KF) have a high incidence of cardiovascular (CV) disease, partly driven by insufficient clearance of uremic toxins. Recent investigations have questioned the accepted effects of adverse lipid profile and CV risk in uremic ...
Sam Hobson, Henriette de Loor, Karolina Kublickiene, Joachim Beige, Pieter Evenepoel, Peter Stenvinkel, Thomas Ebert   +6 more
doaj   +1 more source