Results 31 to 40 of about 15,787 (202)

Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives

Toxins, 2023
During the past decades, the gut microbiome emerged as a key player in kidney disease. Dysbiosis-related uremic toxins together with pro-inflammatory mediators are the main factors in a deteriorating kidney function.
Gianvito Caggiano, Alessandra Stasi, Rossana Franzin, Marco Fiorentino, Maria Teresa Cimmarusti, Annamaria Deleonardis, Rita Palieri, Paola Pontrelli, Loreto Gesualdo   +8 more
doaj   +1 more source

Uremic Vascular Calcification: The Pathogenic Roles and Gastrointestinal Decontamination of Uremic Toxins

Toxins, 2020
Uremic vascular calcification (VC) commonly occurs during advanced chronic kidney disease (CKD) and significantly increases cardiovascular morbidity and mortality.
Chia-Ter Chao, Shih-Hua Lin
doaj   +1 more source

Role of Uremic Toxins in Early Vascular Ageing and Calcification

Toxins, 2021
In patients with advanced chronic kidney disease (CKD), the accumulation of uremic toxins, caused by a combination of decreased excretion secondary to reduced kidney function and increased generation secondary to aberrant expression of metabolite genes ...
Nikolaos C. Kyriakidis, Gabriela Cobo, Lu Dai, Bengt Lindholm, Peter Stenvinkel   +4 more
doaj   +1 more source

Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3. [PDF]

PLoS ONE, 2013
The accumulated uremic toxins inhibit the expression of various renal transporters and this inhibition may further reduce renal function and subsequently cause the accumulation of uremic toxins.
Yasutoshi Akiyama, Koichi Kikuchi, Daisuke Saigusa, Takehiro Suzuki, Yoichi Takeuchi, Eikan Mishima, Yasuaki Yamamoto, Ayako Ishida, Daiki Sugawara, Daisuke Jinno, Hisato Shima, Takafumi Toyohara, Chitose Suzuki, Tomokazu Souma, Takashi Moriguchi, Yoshihisa Tomioka, Sadayoshi Ito, Takaaki Abe   +17 more
doaj   +1 more source

Organic Anion Transporting Polypeptides 1B1 and 1B3 Play an Important Role in Uremic Toxin Handling and Drug-Uremic Toxin Interactions in the Liver

Journal of Pharmacy & Pharmaceutical Sciences, 2014
PURPOSE. Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs ...
Toshihiro Sato, Hiroaki Yamaguchi, Takuma Kogawa, Takaaki Abe, Nariyasu Mano   +4 more
doaj   +1 more source

Modeling Uremic Vasculopathy With Induced Pluripotent Stem Cell-Derived Endothelial Cells as a Drug Screening System

Frontiers in Cell and Developmental Biology, 2021
Background: Cardiovascular complications are the leading cause of mortality in patients with chronic kidney disease (CKD). Uremic vasculopathy plays a crucial role in facilitating the progression of cardiovascular complications in advanced CKD.
Hye Ryoun Jang, Hyung Joon Cho, Yang Zhou, Ning-Yi Shao, Kyungho Lee, Hoai Huong Thi Le, Junseok Jeon, Jung Eun Lee, Wooseong Huh, Sang-Ging Ong, Sang-Ging Ong, Won Hee Lee, Yoon-Goo Kim   +12 more
doaj   +1 more source

The Microbiome and Uremic Solutes

Toxins, 2022
Uremic retention solutes, especially the protein-bound compounds, are toxic metabolites, difficult to eliminate with progressive renal functional decline.
Nadim Zaidan, Lama Nazzal
doaj   +1 more source

Association between Dental Scores and Saliva Uremic Toxins

Toxins, 2023
Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins ...
Claire Rigothier, Sylvain Catros, Antoine Bénard, Johan Samot, Olivier Quintin, Christian Combe, Islam Larabi, Ziad Massy, Jean-Claude Alvarez   +8 more
doaj   +1 more source

New insights in uremic toxins [PDF]

Kidney International, 2003
The retention in the body of compounds, which normally are secreted into the urine results in a clinical picture, called the uremic syndrome. The retention compounds responsible for the uremic syndrome are called uremic toxins. Only a few of the uremic retention solutes fully conform to a true definition of uremic toxins.
Vanholder, Raymond, Glorieux, Griet, De Smet, Rita, Lameire, Norbert   +3 more
openaire   +2 more sources

Comprehensive Bibliometric Analysis of Uremic Toxin Research

Toxins
Uremic toxins accumulate as kidney disease progresses, contributing to diverse systemic disorders. Despite numerous studies, no comprehensive mapping has been performed.
Marsuki Hardjo, Takuya Wakamatsu, Kazuki Watanabe, Shoko Yamazaki, Suguru Yamamoto   +4 more
doaj   +1 more source