Results 1 to 10 of about 60,288 (162)

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

Cell Metabolism, 2020
Summary The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-microbiota-derived signals supports the maintenance of tolerance.
Christoph Bock, André F Rendeiro, Claudia Mauri   +2 more
exaly   +2 more sources

The aryl hydrocarbon receptor and the gut–brain axis

Cellular and Molecular Immunology, 2021
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with ...
Francisco J. Quintana, João Vitor Mahler, Andreia Gonçalves   +2 more
exaly   +2 more sources

Aryl Hydrocarbon Receptor Mechanisms Affecting Chronic Kidney Disease

Frontiers in Pharmacology, 2022
The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix transcription factor that binds diverse endogenous and xenobiotic ligands, which regulate AHR stability, transcriptional activity, and cell signaling.
Colleen S. Curran, Jeffrey B. Kopp
doaj   +2 more sources

Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor

Nature Communications, 2022
The aryl hydrocarbon receptor (AHR) plays important roles in regulating xenobiotic metabolism, cellular differentiation, and immunity. Here, the authors present multiple crystal structures of the Drosophila AHR PAS-B domain, providing insights into the ...
Shuyan Dai, Lingzhi Qu, Jun Li, Ye Zhang, Longying Jiang, Hudie Wei, Ming Guo, Xiaojuan Chen, Yongheng Chen   +8 more
doaj   +2 more sources

Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

Nature Communications, 2021
Necrotizing enterocolitis (NEC) is a disease of prematurity requiring Toll-like receptor 4 (TLR4) activation on the gut epithelium. Here the authors show that the aryl hydrocarbon receptor (AHR) mediates NEC pathogenesis via effects on TLR4, and that ...
Peng Lu, Yukihiro Yamaguchi, William B. Fulton, Sanxia Wang, Qinjie Zhou, Hongpeng Jia, Mark L. Kovler, Andres Gonzalez Salazar, Maame Sampah, Thomas Prindle, Peter Wipf, Chhinder P. Sodhi, David J. Hackam   +12 more
doaj   +2 more sources

Aryl Hydrocarbon Receptor in Health and Disease [PDF]

MedComm
The aryl hydrocarbon receptor (AhR) functions as a ligand‐dependent transcription factor, serving as a pivotal environmental sensor that significantly influences both physiological and pathological processes.
Haonan Li, Yufeng Fan, Jizheng Liu, Shumin Dong, Bin Wen, Yunfei Zhang, Xiaocui Wang, Xuemei Duan, Ying Hu, Ze Yan, Huifeng Shang, Yukai Jing   +11 more
doaj   +2 more sources

The aryl hydrocarbon receptor: structure, signaling, physiology and pathology. [PDF]

Signal Transduct Target Ther
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor of the bHLH/PAS protein family. In this review, we explore the multifaceted roles of AHR in both health and disease, tracing its recognition as a xenobiotic sensor and a ...
Coumoul X, Barouki R, Esser C, Haarmann-Stemmann T, Lawrence BP, Lehmann J, Moura-Alves P, Murray IA, Opitz CA, Perdew GH, Bourguet W.   +10 more
europepmc   +2 more sources

Roles of aryl hydrocarbon receptors in diesel exhaust inhalation-induced cardiopulmonary toxicities during initiation of pulmonary respiration in chicken

环境与职业医学, 2023
BackgroundDue to the limited availability of established research models, very few studies addressed the health effects and underlying mechanisms following exposure to diesel exhaust during the initiation of pulmonary respiration.
Hao NI, Jing JI, Yajie GUO, Shuping ZHONG, Qixiao JIANG   +4 more
doaj   +1 more source

Polygonum tinctorium leaves suppress sodium dextran sulfate-induced colitis through interleukin-10-related pathway

Biochemistry and Biophysics Reports, 2022
Indigo naturalis, a herbal medicine purified from indigo-containing plants, such as Strobilanthes cusia, Isatis tinctoria, and Polygonum tinctorium, has been reported to be useful in the treatment of ulcerative colitis by activating the aryl hydrocarbon ...
Taka Asari, Hidezumi Kikuchi, Shogo Kawaguchi, Hirotake Sakuraba, Shukuko Yoshida, Yui Akemoto, Takato Maeda, Ota Shinji, Yasuhisa Murai, Naoki Higuchi, Kentaro Hoshi, Yukari Fukutoku, Hiroto Hiraga, Kenroh Sasaki, Shinsaku Fukuda   +14 more
doaj   +1 more source

Vitiligo patients show significant up-regulation of aryl hydrocarbon receptor transcription factor [PDF]

Anais Brasileiros de Dermatologia, 2018
: IL-22 has been implicated in the pathogenesis of vitiligo. However, the role of aryl hydrocarbon receptor transcription factor that acts as a master regulator of IL-22-producing Th22 cells is not fully understood.
Farinaze Behfarjam, Zohreh Jadali
doaj   +1 more source