Results 1 to 10 of about 60,384 (208)

Symurban Nanocrystals for Advanced Anti-Pollution Skincare [PDF]

, 2020
Several of most common dermatoses worldwide, e.g., psoriasis and atopic dermatitis, are worsened in their clinical picture when the skin is regularly exposed to an increased air pollution level, e.g., particulate matter.
Köpke, Daniel, Pyo, Sung Min
core   +1 more source

The aryl hydrocarbon receptor system [PDF]

dmdi, 2012
Abstract The aryl hydrocarbon receptor (AhR) recognizes a large number of xenobiotics, such as polyaromatic hydrocarbons (PAHs) and dioxins, and it activates several metabolic and detoxification pathways. Recent evidence suggests that this receptor also has important endogenous functions subsequent to activation by natural dietary ...
Barouki, Robert, Aggerbeck, Martine, Aggerbeck, Lawrence, Coumoul, Xavier   +3 more
openaire   +2 more sources

Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal alpha-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma Predisposition [PDF]

, 2012
PMCID: PMC3534021This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Laenger, A Puga, A Raitila, AF Daly, AF Daly, AJ Perry, AP Heaney, B Bukau, B Panaretou, BD Hollingshead, C Prodromou, C Prodromou, C Scheufler, CA Leontiou, Chrisostomos Prodromou, CM Greiser, D Spengler, DR Bell, E Heliovaara, EB Krissinel, F Glaser, G Huang, G Siligardi, G Trivellin, GB Bolger, Giampaolo Trivellin, Giorgio Colombo, H Ashkenazy, HS Chahal, HS Chahal, HS Chahal, HS Feigelson, I Persson, IW Davis, JL Marlowe, LA Carver, LA Carver, Laura C. Hernández-Ramírez, LH Pearl, Lihong Zhou, M Fujimoto, M Landau, M Linnert, M Yano, M Zhang, MP Mayer, Márta Korbonits, N Kuzhandaivelu, O Vierimaa, P Emsley, P Pocar, PH Pang, PV Afonine, Q Zeng, Rhodri M. L. Morgan, S Igreja, S Safe, S. Mark Roe, SK de Oliveira, SK de Oliveira, SK Kolluri, W Cai, Z Ozfirat   +62 more
core   +10 more sources

Role of the aryl hydrocarbon receptor in Sugen 5416-induced experimental pulmonary hypertension [PDF]

, 2018
Rationale: Rats dosed with the vascular endothelial growth factor (VEGF) inhibitor Sugen 5416 (Su), placed in hypoxia then restored to normoxia has become a widely used model of pulmonary arterial hypertension (PAH).
Dean, Afshan, Docherty, Craig K., Gregorc, Teja, Harvey, Katie Y., MacLean, Margaret R., Morrell, Nicholas W., Nilsen, Margaret   +6 more
core   +1 more source

A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC [PDF]

, 2015
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data
Barollo, Susi, Bertazza, Loris, Bisognin, Andrea, Bortoluzzi, Stefania, Boscaro, Marco, Ceccato, Filippo, Ciato, Denis, Galuppini, Francesca, Guzzardo, Vincenza, Jaffrain Rea, Marie Lise, Mian, Caterina, Occhi, Gianluca, Pennelli, Gianmaria, Regazzo, Daniela, Scaroni, Carla, Vianello, Federica, WATUTANTRIGE FERNANDO, Sara   +16 more
core   +4 more sources

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source

Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]

, 2016
Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A., De Luca, C., Korkina, L., Ozben, T., Saso, Luciano   +4 more
core   +3 more sources

Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene [PDF]

, 2017
Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene.
Catchpole, B, Church, D B, Forcada, Y, Fowkes, R C, Niessen, S J M, Scudder, C J   +5 more
core   +2 more sources

Aryl hydrocarbon receptor and intestinal immunity [PDF]

Mucosal Immunology, 2018
Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular responses to environmental stimuli, such as xenobiotics and oxygen levels. Unlike other members of bHLH, AhR is the only bHLH transcription factor that is known to be ligand activated.
Lamas, Bruno, Natividad, Jane, Sokol, Harry   +2 more
openaire   +3 more sources

The Ah receptor: adaptive metabolism, ligand diversity, and the xenokine model [PDF]

, 2020
Author Posting. © American Chemical Society, 2020. This is an open access article published under an ACS AuthorChoice License. The definitive version was published in Chemical Research in Toxicology, 33(4), (2020): 860-879, doi:10.1021/acs.chemrestox ...
Avilla, Mele N., Bradfield, Christopher A., Hahn, Mark E., Malecki, Kristen M. C., Wilson, Rachel H.   +4 more
core   +1 more source