Results 31 to 40 of about 33,160 (231)

Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β

BMC Pharmacology and Toxicology, 2022
Background The main causes of lung cancer are smoking, environmental pollution and genetic susceptibility. It is an indisputable fact that PAHs are related to lung cancer, and benzo(a) pyrene is a representative of PAHs.
Mengdi Zhang, Yuxia Hu, Fan Yang, Jingwen Zhang, Jianxin Zhang, Wanjia Yu, Minjie Wang, Xiaoli Lv, Jun Li, Tuya Bai, Fuhou Chang   +10 more
doaj   +1 more source

Targeting Aryl Hydrocarbon Receptor Signaling Enhances Type I Interferon-Independent Resistance to Herpes Simplex Virus

Microbiology Spectrum, 2021
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcript factor that plays an important role in regulating immunity and cell differentiation. However, its role in cell-autonomous antiviral resistance has not been fully elucidated.
Jincheng Chen, Juan Liang, Hui Xu, Wenqi Liu, Shuyan Liu, Lian Duan, Fang Li, Zhaoqin Wang, Yingxia Liu, Brian McSharry, Carl G. Feng, Guoliang Zhang   +11 more
doaj   +1 more source

Aryl hydrocarbon receptor and intestinal immunity [PDF]

Mucosal Immunology, 2018
Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular responses to environmental stimuli, such as xenobiotics and oxygen levels. Unlike other members of bHLH, AhR is the only bHLH transcription factor that is known to be ligand activated.
Lamas, Bruno, Natividad, Jane, Sokol, Harry   +2 more
openaire   +3 more sources

The Aryl Hydrocarbon Receptor in Asthma: Friend or Foe? [PDF]

International Journal of Molecular Sciences, 2020
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has emerged as an important player in asthma control. AhR is responsive to environmental molecules and endogenous or dietary metabolites and regulates innate and adaptive immune responses.
Poulain-Godefroy, Odile, Bouté, Mélodie, Carrard, Julie, Alvarez-Simon, Daniel, Tsicopoulos, Anne, de Nadai, Patricia   +5 more
openaire   +4 more sources

The Aryl Hydrocarbon Receptor and the Nervous System [PDF]

International Journal of Molecular Sciences, 2018
The aryl hydrocarbon receptor (or AhR) is a cytoplasmic receptor of pollutants. It translocates into the nucleus upon binding to its ligands, and forms a heterodimer with ARNT (AhR nuclear translocator). The heterodimer is a transcription factor, which regulates the transcription of xenobiotic metabolizing enzymes.
Ludmila Juricek, Xavier Coumoul
openaire   +2 more sources

Aryl hydrocarbon receptor controls regulatory CD4+T cell function

Swiss Medical Weekly, 2012
The ligand activated transcription factor aryl hydrocarbon receptor (AhR) has been studied for many decades in toxicology as the ligand for the environmental contaminant dioxin. However, AhR has recently emerged as a critical physiological regulator
Caroline Pot
doaj   +1 more source

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

Nature Communications, 2022
Aryl hydrocarbon receptor (AHR) is a sensor of the chemical environment including pollutants, diet components and metabolites. Here, authors determine the structure of the indirubin-bound AHR cytosolic complex providing mechanistic insights into ligand ...
Jakub Gruszczyk, Loïc Grandvuillemin, Josephine Lai-Kee-Him, Matteo Paloni, Christos G. Savva, Pierre Germain, Marina Grimaldi, Abdelhay Boulahtouf, Hok-Sau Kwong, Julien Bous, Aurélie Ancelin, Cherine Bechara, Alessandro Barducci, Patrick Balaguer, William Bourguet   +14 more
doaj   +1 more source

Plasma Aryl Hydrocarbon Receptor Agonist Activity Is Associated With Inflammation and Metabolic Dysregulation in Obesity: A Cross-Sectional Study. [PDF]

Diabetes Metab Res Rev
ABSTRACT Background The aryl hydrocarbon receptor (AhR) is linked to inflammation, but its plasma agonist activity and association with metabolic and inflammatory markers in obesity remain unclear. This cross‐sectional study aimed to determine the level of plasma AhR agonistic activity and its association with systemic inflammation and metabolic ...
Bahman F, Kochumon S, Al Madhoun A, Al-Roub A, Bennakhi A, Arouj M, Al-Mulla F, Ahmad R.   +7 more
europepmc   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The aryl hydrocarbon receptor and food allergy [PDF]

Veterinary Quarterly, 2013
The immune system is important for protection against pathogens and malignant cells. However, malfunction of the immune system can also result in detrimental auto-immune diseases, inflammatory diseases, cancers and allergies. The aryl hydrocarbon receptor (AhR), present in numerous tissues and cell subsets, including cells of the immune system, plays ...
Schulz, V.J., Smit, J.J., Pieters, R.H.H.   +2 more
openaire   +3 more sources