Results 31 to 40 of about 1,542,659 (289)

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Nature Medicine, 2016
Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and caspase recruitment domain family member 9 (CARD9), a susceptibility gene ...
B. Lamas, Mathias L. Richard, Valentin Leducq, H. Pham, Marie‐Laure Michel, G. da Costa, C. Bridonneau, S. Jégou, Thomas W. Hoffmann, J. Natividad, L. Brot, S. Taleb, A. Couturier-Maillard, I. Nion-Larmurier, F. Merabtene, P. Seksik, A. Bourrier, J. Cosnes, B. Ryffel, L. Beaugerie, J. Launay, P. Langella, R. Xavier, H. Sokol   +23 more
semanticscholar   +1 more source

Aryl Hydrocarbon Receptor: From Homeostasis to Tumor Progression

Frontiers in Cell and Developmental Biology, 2022
Transcription factor aryl hydrocarbon receptor (AHR) has emerged as one of the main regulators involved both in different homeostatic cell functions and tumor progression.
Claudia Rejano-Gordillo, Ana Ordiales-Talavero, Ana Nacarino-Palma, Jaime M. Merino, Francisco J. González-Rico, Pedro M. Fernández-Salguero   +5 more
doaj   +1 more source

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

International Journal of Molecular Sciences, 2022
The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery of genes involved in the metabolism of xenobiotics and endogenous compounds.
A. Grishanova, M. Perepechaeva
semanticscholar   +1 more source

The Immunophilin-Like Protein XAP2 Is a Negative Regulator of Estrogen Signaling through Interaction with Estrogen Receptor alpha [PDF]

, 2011
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Petra Berg, Pongratz, I,, Kramarova Tatiana V., Cai, W, Pongratz Ingemar, Tatiana V. Kramarova, Berg, P, Berg Petra, Ingemar Pongratz, Korbonits Marta, Korbonits, M, Cai Wen, Kramarova, TV, Marta Korbonits, Tatiana V Kramarova, Wen Cai, Pongratz, I   +16 more
core   +2 more sources

Bioassay-Driven, Fractionation-Empowered, Focused Metabolomics for Discovering Bacterial Activators of Aryl Hydrocarbon Receptor [PDF]

, 2023
Aryl hydrocarbon receptor (AhR) is a transcription factor that regulates gene expression upon ligand activation, enabling microbiota-dependent induction, training, and function of the host immune system. A spectrum of metabolites, encompassing indole and
Lei, Wang, Rachel, Hardy, Lindsey, Placek, Lina, Kozhaya, Elizabeth, Fleming, Derya, Unutmaz, Xudong, Yao, Julia, Oh, Huidi, Tian   +8 more
core   +2 more sources

Potential role of PM2.5 in melanogenesis

Environment International, 2019
Ambient particulate matter 2.5 (PM2.5) is one of the main components of air pollutants, which can absorb many polycyclic aromatic hydrocarbons and metals.
Fen Peng, Gaku Tsuji, Jian-zhong Zhang, Zhou Chen, Masutaka Furue   +4 more
doaj   +1 more source

Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal alpha-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma Predisposition [PDF]

, 2012
PMCID: PMC3534021This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Chrisostomos Prodromou, Rhodri M. L. Morgan, Giampaolo Trivellin, Lihong Zhou, Lihong Zhou (106007), Prodromou, C, Zhou Lihong, Korbonits Márta, Chrisostomos Prodromou (4463035), Rhodri M L Morgan, Hernandez-Ramirez, LC, Laura C Hernández-Ramírez (16156643), Trivellin Giampaolo, Márta Korbonits, Laura C. Hernández-ramı́rez, Giampaolo Trivellin (106006), Trivellin, G, Zhou, L, Laura C Hernández-Ramírez, S. Mark Roe, S. Mark Roe (22167), Márta Korbonits (59514), Rhodri M. L. Morgan (106004), Prodromou Chrisostomos, Roe S. Mark, Hernández-Ramírez Laura C., S Mark Roe, Korbonits, M, Morgan Rhodri M. L., Chrisostomos Prodromou (106010), Morgan, RML, Rhodri M L Morgan (16156640), Roe, SM, Laura C. Hernández-Ramírez (106005)   +33 more
core   +1 more source

Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance While the effects of gut microbes on brain development and function have been described, the mechanisms remain largely unknown. Here, we report that tryptophan-metabolizing gut microbes secrete indoles that regulate neurogenesis in the adult
George Z Wei, Katherine A. Martin, Peter Yuli Xing, R. Agrawal, L. Whiley, T. Wood, Sophia Hejndorf, Yong-Zhi Ng, J. Low, J. Rossant, Robert Nechanitzky, E. Holmes, J. Nicholson, E. Tan, P. Matthews, S. Pettersson   +15 more
semanticscholar   +1 more source

Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure [PDF]

, 2010
The mineralocorticoid receptor (MR) binds the steroid hormones aldosterone and cortisol and has an important physiological role in the control of salt homeostasis.
Fischer, Katharina, Watt, Carolyn, McEwan, Iain Joseph, Nicholas C. Price, Kelly, S.M., Katharina Fischer, Price, N.C., McEwan, I. J., Watt, K., Fischer, K., Price, Nicholas C., Sharon M. Kelly, Kate Watt, Iain J. McEwan, Kelly, Sharon M.   +14 more
core   +1 more source

Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. [PDF]

PLoS ONE, 2013
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of structurally diverse chemicals.
Qin Hu, Guochun He, Jing Zhao, Anatoly Soshilov, Michael S Denison, Aiqian Zhang, Huijun Yin, Domenico Fraccalvieri, Laura Bonati, Qunhui Xie, Bin Zhao   +10 more
doaj   +1 more source