Results 21 to 30 of about 33,261 (251)

Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor. [PDF]

PLoS ONE, 2014
Azole antifungal ketoconazole (KET) was demonstrated to activate aryl hydrocarbon receptor (AhR). Since clinically used KET is a racemic mixture of two cis-enantiomers (2R,4S)-(+)-KET and (2S,4R)-(-)-KET, we examined the effects of KET enantiomers on AhR
Aneta Novotna, Martina Korhonova, Iveta Bartonkova, Anatoly A Soshilov, Michael S Denison, Katerina Bogdanova, Milan Kolar, Petr Bednar, Zdenek Dvorak   +8 more
doaj   +1 more source

The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis

Cell Reports, 2018
Summary: Zebrafish have a high capacity to replace lost neurons after brain injury. New neurons involved in repair are generated by a specific set of glial cells, known as ependymoglial cells.
Rossella Di Giaimo, Tamara Durovic, Pablo Barquin, Anita Kociaj, Tjasa Lepko, Sven Aschenbroich, Christopher T. Breunig, Martin Irmler, Filippo M. Cernilogar, Gunnar Schotta, Joana S. Barbosa, Dietrich Trümbach, Emily Violette Baumgart, Andrea M. Neuner, Johannes Beckers, Wolfgang Wurst, Stefan H. Stricker, Jovica Ninkovic   +17 more
doaj   +1 more source

Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor

Frontiers in Immunology, 2022
Rheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels.
Xiaoyu Xi, Xiaoyu Xi, Qinbin Ye, Qinbin Ye, Danping Fan, Danping Fan, Xiaoxue Cao, Xiaoxue Cao, Qiong Wang, Qiong Wang, Xing Wang, Xing Wang, Mengxiao Zhang, Yuan Xu, Cheng Xiao, Cheng Xiao   +15 more
doaj   +1 more source

Honeybee gut Lactobacillus modulates host learning and memory behaviors via regulating tryptophan metabolism

Nature Communications, 2022
Eusocial honeybee is a versatile model for neurobiological research. Here, the authors established a link between honeybee gut Lactobacillus in bee learning and memory ability via indole derivatives that activate host’s aryl hydrocarbon receptor.
Zijing Zhang, Xiaohuan Mu, Qina Cao, Yao Shi, Xiaosong Hu, Hao Zheng   +5 more
doaj   +1 more source

Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

Nature Communications, 2021
Necrotizing enterocolitis (NEC) is a disease of prematurity requiring Toll-like receptor 4 (TLR4) activation on the gut epithelium. Here the authors show that the aryl hydrocarbon receptor (AHR) mediates NEC pathogenesis via effects on TLR4, and that ...
Peng Lu, Yukihiro Yamaguchi, William B. Fulton, Sanxia Wang, Qinjie Zhou, Hongpeng Jia, Mark L. Kovler, Andres Gonzalez Salazar, Maame Sampah, Thomas Prindle, Peter Wipf, Chhinder P. Sodhi, David J. Hackam   +12 more
doaj   +1 more source

Regulation of Intestinal Stem Cell Stemness by the Aryl Hydrocarbon Receptor and Its Ligands

Frontiers in Immunology, 2021
Maintenance of intestinal homeostasis requires the integration of immunological and molecular processes together with environmental, diet, metabolic and microbial cues.
Paul J. Wisniewski, Mitzi Nagarkatti, Prakash S. Nagarkatti   +2 more
doaj   +1 more source

The aryl hydrocarbon receptor in tumor immunity [PDF]

OncoImmunology, 2012
The aryl hydrocarbon receptor (AHR) binds environmental toxins and mediates immune regulation. The tryptophan metabolite kynurenine has now been identified as an endogenous ligand of the human AHR constitutively produced by gliomas and other types of cancer via tryptophan-2,3-dioxygenase (TDO), thereby suppressing antitumor immune responses via the AHR.
Platten, Michael, Litzenburger, Ulrike, Wick, Wolfgang   +2 more
openaire   +2 more sources

Insight into the Role of the Aryl Hydrocarbon Receptor in Bovine Coronavirus Infection by an Integrated Approach Combining In Vitro and In Silico Methods

Microorganisms
It is well known that the host response to different human and animal coronaviruses infection is regulated by the aryl hydrocarbon receptor, a ligand-activated transcription factor.
Luca Del Sorbo, Clementina Acconcia, Maria Michela Salvatore, Giovanna Fusco, Violetta Vasinioti, Maria Stella Lucente, Liqian Zhu, Annamaria Pratelli, Luigi Russo, Anna Andolfi, Rosa Iacovino, Filomena Fiorito   +11 more
doaj   +1 more source

Targeting Aryl Hydrocarbon Receptor Signaling Enhances Type I Interferon-Independent Resistance to Herpes Simplex Virus

Microbiology Spectrum, 2021
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcript factor that plays an important role in regulating immunity and cell differentiation. However, its role in cell-autonomous antiviral resistance has not been fully elucidated.
Jincheng Chen, Juan Liang, Hui Xu, Wenqi Liu, Shuyan Liu, Lian Duan, Fang Li, Zhaoqin Wang, Yingxia Liu, Brian McSharry, Carl G. Feng, Guoliang Zhang   +11 more
doaj   +1 more source

Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β

BMC Pharmacology and Toxicology, 2022
Background The main causes of lung cancer are smoking, environmental pollution and genetic susceptibility. It is an indisputable fact that PAHs are related to lung cancer, and benzo(a) pyrene is a representative of PAHs.
Mengdi Zhang, Yuxia Hu, Fan Yang, Jingwen Zhang, Jianxin Zhang, Wanjia Yu, Minjie Wang, Xiaoli Lv, Jun Li, Tuya Bai, Fuhou Chang   +10 more
doaj   +1 more source