Results 21 to 30 of about 1,542,659 (289)

The key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor

Frontiers in Immunology, 2022
The aryl hydrocarbon receptor was previously known as an environmental receptor that modulates the cellular response to external environmental changes. In essence, the aryl hydrocarbon receptor is a cytoplasmic receptor and transcription factor that is ...
Jingwen Wu, Tianyi Pang, Ziyuan Lin, Ming Zhao, Hui Jin   +4 more
doaj   +1 more source

MIR-320a/b inhibits cell viability and cell cycle progression by targeting aryl hydrocarbon receptor nuclear translocator-like in acute promyelocyte leukaemia

Polish Journal of Pathology, 2022
Acute promyelocyte leukaemia (APL) is a subgroup of acute myeloid leukaemia. Dysregulation of clock genes has been revealed to be involved in APL progression. Herein, the mechanism of clock gene aryl hydrocarbon receptor nuclear translocator- like (ARNTL)
Dan Hu, Zhenji Shen, Lin Yuan
doaj   +1 more source

Sinomenine ameliorates rheumatoid arthritis by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation.

Science Bulletin, 2023
Gut microbiota dysbiosis is associated with the development of rheumatoid arthritis (RA). Sinomenine (SIN) is an effective immunosuppressive and anti-inflammatory drug used for treating RA, but how SIN regulates gut microbiota to alleviate RA remains ...
Zheng‐Meng Jiang, Su-Ling Zeng, Tian-Qing Huang, Yang Lin, Fang Wang, Xing-Jiao Gao, Jing Li, Ping Li, Ehu Liu   +8 more
semanticscholar   +1 more source

Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice.

Brain, behavior, and immunity, 2022
Gut microbiota alterations might affect the development of Alzheimer's disease (AD) through microbiota-derived metabolites. For example, microbiota-derived Indoles via tryptophan metabolism prevented Aβ accumulation and Tau hyperphosphorylation, restored
J. Sun, Yu-Hong Zhang, Yu Kong, Tao Ye, Qingxia Yu, Senthil Kumaran Satyanarayanan, K. Su, Jiaming Liu   +7 more
semanticscholar   +1 more source

Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice

Nature Communications, 2023
The aryl hydrocarbon receptor regulates the expression of genes involved in many cell processes and its dysregulation has been implicated in different diseases.
Karolína Ondrová, Iveta Zůvalová, Barbora Vyhlídalová, Kristýna Krasulová, Elena Mikova, R. Vrzal, P. Nádvorník, Binod Nepal, S. Kortagere, Martina Kopečná, D. Kopečný, M. Šebela, F. Rastinejad, H. Pu, Miroslav Soural, K. Rolfes, T. Haarmann-Stemmann, Hao Li, S. Mani, Z. Dvořák   +19 more
semanticscholar   +1 more source

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.

Immunity, 2013
Endogenous tryptophan (Trp) metabolites have an important role in mammalian gut immune homeostasis, yet the potential contribution of Trp metabolites from resident microbiota has never been addressed experimentally.
T. Zelante, R. Iannitti, C. Cunha, A. De Luca, G. Giovannini, G. Pieraccini, R. Zecchi, C. D'Angelo, Cristina Massi-Benedetti, F. Fallarino, A. Carvalho, P. Puccetti, L. Romani   +12 more
semanticscholar   +1 more source

Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway

Biochemical Pharmacology, 2022
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating adaptive and maladaptive responses toward exogenous and endogenous signals.
N. C. Sondermann, S. Fassbender, F. Hartung, Anna M. Hätälä, K. Rolfes, Christoph F. A. Vogel, T. Haarmann-Stemmann   +6 more
semanticscholar   +1 more source

Streamlined Access to Novel Activators and Degraders of the Aryl Hydrocarbon Receptor through a Rewired Multicomponent Reaction [PDF]

, 2022
A rewired Yonemitsu multicomponent reaction was designed to readily synthesize a family of 6-substituted indolocarbazoles. In this approach, indole 2-carboxaldehyde and nucleophilic species directly yield the final adducts through a domino reaction.
Marina , Pedrola, Anna, Hätälä, Ismael, Sánchez-Vera, Joan, Gil, Frederick, Hartung, Francisco Javier, Luque, Rodolfo, Lavilla, Ouldouz, Ghashghaei, Alejandro, Diaz, Katharina M., Rolfes, Thomas , Haarmann-Stemmann   +10 more
core   +2 more sources

Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

Gut microbes, 2022
Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between the gut microbiota and its host. However, factors regulating AhR within the gut, which is a complex metabolomic environment, are poorly understood.
Morgane Modoux, N. Rolhion, J. Lefèvre, Cyriane Oeuvray, P. Nádvorník, P. Illés, P. Emond, Y. Parc, S. Mani, Z. Dvořák, H. Sokol   +10 more
semanticscholar   +1 more source

Increased Expression of Aryl Hydrocarbon Receptor in Peripheral Blood Mononuclear Cells of Patients with Autoimmune Hepatitis

Middle East Journal of Digestive Diseases, 2018
BACKGROUND Previous studies have indicated an elevated level of serum Interleukin (IL)-22 in patients with autoimmune hepatitis (AIH). However, there are no experimental data on the master transcription factor (aryl hydrocarbon receptor) that plays an ...
Farinaz Behfarjam, Zohreh Jadali
doaj   +1 more source