Results 21 to 30 of about 33,160 (231)
eLife, 2020 Systemic metabolic reprogramming induced by infection exerts profound, pathogen-specific effects on infection outcome. Here, we detail the host immune and metabolic response during sickness and recovery in a mouse model of malaria.
Michelle M Lissner +7 more
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Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor. [PDF]
PLoS ONE, 2014 Azole antifungal ketoconazole (KET) was demonstrated to activate aryl hydrocarbon receptor (AhR). Since clinically used KET is a racemic mixture of two cis-enantiomers (2R,4S)-(+)-KET and (2S,4R)-(-)-KET, we examined the effects of KET enantiomers on AhR
Aneta Novotna +8 more
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The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis
Cell Reports, 2018 Summary: Zebrafish have a high capacity to replace lost neurons after brain injury. New neurons involved in repair are generated by a specific set of glial cells, known as ependymoglial cells.
Rossella Di Giaimo +17 more
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The aryl hydrocarbon receptor in tumor immunity [PDF]
OncoImmunology, 2012 The aryl hydrocarbon receptor (AHR) binds environmental toxins and mediates immune regulation. The tryptophan metabolite kynurenine has now been identified as an endogenous ligand of the human AHR constitutively produced by gliomas and other types of cancer via tryptophan-2,3-dioxygenase (TDO), thereby suppressing antitumor immune responses via the AHR.
Platten, Michael +2 more
openaire +2 more sources
Frontiers in Immunology, 2022 Rheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels.
Xiaoyu Xi +15 more
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Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
Nature Communications, 2021 Necrotizing enterocolitis (NEC) is a disease of prematurity requiring Toll-like receptor 4 (TLR4) activation on the gut epithelium. Here the authors show that the aryl hydrocarbon receptor (AHR) mediates NEC pathogenesis via effects on TLR4, and that ...
Peng Lu +12 more
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Dopamine is an aryl hydrocarbon receptor agonist
Biochemical Journal, 2020 Tryptophan metabolites exhibit aryl hydrocarbon receptor (AhR) agonist activity and recent studies show that the phenylalanine metabolites serotonin and carbidopa, a drug used in treating Parkinson's disease, activated the AhR. In this study, we identified the neuroactive hormone dopamine as an inducer of drug-metabolizing enzymes CYP1A1, CYP1B1, and ...
Hyejin Park +8 more
openaire +2 more sources
Nature Communications, 2022 Eusocial honeybee is a versatile model for neurobiological research. Here, the authors established a link between honeybee gut Lactobacillus in bee learning and memory ability via indole derivatives that activate host’s aryl hydrocarbon receptor.
Zijing Zhang +5 more
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MicroorganismsIt is well known that the host response to different human and animal coronaviruses infection is regulated by the aryl hydrocarbon receptor, a ligand-activated transcription factor.
Luca Del Sorbo +11 more
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Regulation of Intestinal Stem Cell Stemness by the Aryl Hydrocarbon Receptor and Its Ligands
Frontiers in Immunology, 2021 Maintenance of intestinal homeostasis requires the integration of immunological and molecular processes together with environmental, diet, metabolic and microbial cues.
Paul J. Wisniewski +2 more
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