Results 11 to 20 of about 1,542,659 (289)

Antioxidant Functions of the Aryl Hydrocarbon Receptor [PDF]

Stem Cells International, 2016
The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but ...
Cornelia Dietrich
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Insight into the Role of the Aryl Hydrocarbon Receptor in Bovine Coronavirus Infection by an Integrated Approach Combining In Vitro and In Silico Methods [PDF]

Microorganisms
It is well known that the host response to different human and animal coronaviruses infection is regulated by the aryl hydrocarbon receptor, a ligand-activated transcription factor.
Luca Del Sorbo, Clementina Acconcia, Maria Michela Salvatore, Giovanna Fusco, Violetta Vasinioti, Maria Stella Lucente, Liqian Zhu, Annamaria Pratelli, Luigi Russo, Anna Andolfi, Rosa Iacovino, Filomena Fiorito   +11 more
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The role of immune homeostasis in patients with new coronavirus infection (COVID-19) in the development of invasive pulmonary aspergillosis

Журнал инфектологии, 2023
Recently, more attention has been paid to the role of indolamine-2,3-dioxygenase and aryl hydrocarbon receptor in maintaining a balance between immune reactivity and tolerance in various infectious diseases.
A. E. Taraskina, E. V. Frolova, O. V. Shadrivova, O. V. Sekretareva, N. V. Vasilyeva   +4 more
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Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

Immunity, 2022
SUMMARY The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated macrophage (TAM) function in pancreatic ductal adenocarcinoma (PDAC).
K. Hezaveh, Rahul S. Shinde, Andreas Klötgen, M. Halaby, Sara Lamorte, M. Ciudad, R. Quevedo, Luke Neufeld, Z. Liu, Robbie Jin, Barbara T. Grünwald, E. Foerster, Danica Chaharlangi, Meng-Di Guo, P. Makhijani, Xin Zhang, Trevor J Pugh, Devanand M. Pinto, I. Co, A. McGuigan, G. Jang, R. Khokha, P. Ohashi, G. O'Kane, S. Gallinger, W. Navarre, H. Maughan, D. Philpott, David G. Brooks, T. McGaha   +29 more
semanticscholar   +1 more source

Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota

Journal of molecular medicine, 2023
Gut microbiota in interaction with intestinal host tissues influences many brain functions and microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric conditions and Alzheimer’s disease (AD). l -tryptophan metabolites and short-
A. Salminen
semanticscholar   +1 more source

Repression of the Aryl Hydrocarbon Receptor Prevents Oxidative Stress and Ferroptosis of Intestinal Intraepithelial Lymphocytes

Immunity, 2023
SUMMARY The aryl-hydrocarbon receptor (AHR) is a ligand-activated transcription factor that buoys intestinal immune responses. AHR induces its own negative regulator, the AHR repressor (AHRR).
S. Panda, Vincent Peng, R. Sudan, Alina Ulezko Antonova, B. Di Luccia, Takahiro E. Ohara, J. Fachi, G. Grajales-Reyes, N. Jaeger, Tihana Trsan, S. Gilfillan, M. Cella, M. Colonna   +12 more
semanticscholar   +1 more source

Aryl hydrocarbon receptor overexpression in miniaturized follicles in female pattern hair loss [PDF]

Anais Brasileiros de Dermatologia, 2017
The etiopathogenesis of female pattern hair loss is still poorly understood. In addition to genetic and hormonal elements, environmental factors could be involved.
Paulo Müller Ramos, Gabrielli Brianezi, Ana Carolina Pereira Martins, Márcia Guimarães da Silva, Mariângela Esther Alencar Marques, Hélio Amante Miot   +5 more
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Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs. [PDF]

PLoS ONE, 2013
The aryl hydrocarbon receptor (AHR) mediates biological responses to toxic chemicals. An unexpected role for AHR in vascularization was suggested when mice lacking AHR displayed impaired closure of the ductus venosus after birth, as did knockout mice for
Frank G van Steenbeek, Bart Spee, Louis C Penning, Anne Kummeling, Ingrid H M van Gils, Guy C M Grinwis, Dik Van Leenen, Frank C P Holstege, Manon Vos-Loohuis, Jan Rothuizen, Peter A J Leegwater   +10 more
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Lung cancer associated with combustion particles and fine particulate matter (PM2.5) - The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon receptor (AhR)

Biochemical Pharmacology, 2023
Air pollution is the leading cause of lung cancer after tobacco smoking, contributing to 20% of all lung cancer deaths. Increased risk associated with living near trafficked roads, occupational exposure to diesel exhaust, indoor coal combustion and ...
J. Holme, J. Vondráček, M. Machala, D. Lagadic-Gossmann, Christoph F. A. Vogel, E. Le Ferrec, L. Sparfel, J. Øvrevik   +7 more
semanticscholar   +1 more source

Tapinarof Validates the Aryl Hydrocarbon Receptor as a Therapeutic Target: A Clinical Review.

Journal of Allergy and Clinical Immunology, 2023
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that has wide-ranging roles, including regulation of inflammation and homeostasis.
J. Silverberg, M. Boguniewicz, Francisco J. Quintana, Rachael A Clark, Lara M Gross, I. Hirano, A. Tallman, P. Brown, Doral Fredericks, D. Rubenstein, Kimberly A McHale   +10 more
semanticscholar   +1 more source