Results 1 to 10 of about 66,077 (262)

Correlation of susceptibility to ortho-aminoazotolueneinduced hepatocarcinogenesis with Car and Ahr signaling pathway activation in mice

open access: yesВавиловский журнал генетики и селекции, 2015
Ortho-aminoazotoluene (OAT) is a potent hepatocarcinogen for most strains of mice. It has previously been shown that OAT application activates the aryl hydrocarbon receptor (Ahr) and the constitutive androstane receptor (Car) in the mouse liver.
N. V. Baginskaya   +5 more
doaj   +1 more source

Exploring the impact of endogenous AHR ligand, 6-formylindole [3,2-b]carbazole (FICZ) on the microbiota-gut-brain axis in chronic stress-induced depression in rats [PDF]

open access: yesTrends in Pharmaceutical Sciences
Aryl hydrocarbon receptor (AHR) is a nuclear receptor that mediates responses to environmental stimuli. The microbiome, influenced by factors such as nutrition, antibiotics, stress, and infection, plays a crucial role in mood, cognition, and mental ...
Najmeh Ekhtiyardar   +6 more
doaj   +1 more source

Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress

open access: yes4 open, 2019
The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

open access: yesGut Microbes, 2022
Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between the gut microbiota and its host. However, factors regulating AhR within the gut, which is a complex metabolomic environment, are poorly understood.
Morgane Modoux   +10 more
doaj   +1 more source

Actualisation / (re)contextualisation des textes patrimoniaux : d’un questionnement épistémologique à des questions d’ordre didactique

open access: yesRecherches & Travaux, 2017
The article first tackles epistemological questioning on the meaning of actualization and (re)contextualization of literary texts both by the “ideal reader” as well as by the real reader. Then it highlights the need to articulate both perspectives in the
Sylviane Ahr
doaj   +1 more source

Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications

open access: yesCells, 2022
Target modulation of the AhR for inflammatory gastrointestinal (GI) conditions holds great promise but also the potential for safety liabilities both within and beyond the GI tract.
Samantha C. Faber   +7 more
doaj   +1 more source

Aryl Hydrocarbon Receptor is Essential in the Control of Lung Club Cell Homeostasis

open access: yesJournal of Inflammation Research, 2021
Kwei-Yan Liu,1 Li-Ting Wang,2 Hsueh-Chun Wang,3,4 Shen-Nien Wang,5– 7 Li-Wen Tseng,5 Chee-Yin Chai,8 Shyh-Shin Chiou,9,10 Shau-Ku Huang,1,11 Shih-Hsien Hsu5,12,13 1Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen ...
Liu KY   +8 more
doaj  

Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation

open access: yesCell & Bioscience, 2023
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a classical exogenous synthetic ligand of AHR that has significant immunotoxic effects.
Yue Chen   +4 more
doaj   +1 more source

Aryl hydrocarbon receptor maintains hepatic mitochondrial homeostasis in mice

open access: yesMolecular Metabolism, 2023
Objective: Mitophagy removes damaged mitochondria to maintain cellular homeostasis. Aryl hydrocarbon receptor (AhR) expression in the liver plays a crucial role in supporting normal liver functions, but its impact on mitochondrial function is unclear ...
Mi Jeong Heo   +8 more
doaj   +1 more source

Approches analytiques de la littérature à l’articulation collège/lycée : questions pour la recherche

open access: yesRepères, 2020
The article presents and questions the methodological choices made within the framework of the PELAS (Effective practices of analytical reading in secondary education in France and Belgium) research programme with regard to its stakes and its object, on ...
Sylviane Ahr, Isabelle De Peretti
doaj   +1 more source

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