Results 11 to 20 of about 66,077 (262)

The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions [PDF]

International Journal of Molecular Sciences, 2021
The aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates numerous cellular responses. Originally investigated in toxicology because of its ability to bind environmental contaminants, AhR has attracted enormous attention in the field of immunology in the last 20 years.
Marco Gargaro, Giulia Scalisi, Giorgia Manni   +2 more
exaly   +3 more sources

Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs) [PDF]

International Journal of Molecular Sciences, 2020
The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that bound and mediated the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and dioxin-like compounds (DLCs). Subsequent studies show that the AhR plays an important role in maintaining cellular homeostasis and in pathophysiology, and there is ...
Stephen Safe, Un-Ho Jin, Robert S Chapkin   +2 more
exaly   +3 more sources

Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators: Genomic studies [PDF]

Current Opinion in Toxicology, 2018
The aryl hydrocarbon receptor (AhR) binds structurally diverse ligands that vary from the environmental toxicant 2,3,7,8-tetrachlorodibenzo-B-dioxin (TCDD) to AhR- active pharmaceuticals and health-promoting phytochemicals. There are remarkable differences in the toxicity of TCDD and related halogenated aromatics (HAs) vs. health promoting AhR ligands,
Stephen Safe, Huajun Han, Kumaravel Mohankumar   +2 more
exaly   +3 more sources

Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands

Cellular Physiology and Biochemistry, 2020
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter and hormone with important physiological functions in many organs, including the intestine. We have previously shown that 5-HT activates the aryl hydrocarbon receptor (AhR) in intestinal epithelial cells (IECs) via a serotonin transporter (SERT)-dependent mechanism.
Christopher R. Manzella, Max Ackerman, Megha Singhal, Alexander L. Ticho, Justin Ceh, Waddah A. Alrefai, Seema Saksena, Pradeep K. Dudeja, Ravinder K. Gill   +8 more
doaj   +3 more sources

« Le Lac » de Lamartine : quels usages pour quels enjeux lorsque l’extrait se substitue à l’œuvre ?

Repères, 2021
This article examines the uses and objectives – prescribed by the institution and recommended by textbooks over the past four decades, but also questioned by teachers on their dedicated websites – of Lamartine’s poem “The Lake” during lessons in the ...
Sylviane Ahr
doaj   +1 more source

Study of the Notch-Aromatic Hydrocarbon Receptor-Interleukin-22 Signaling Pathway and the Pathogenesis of Immune Thrombocytopenia

Clinical and Experimental Obstetrics & Gynecology, 2023
Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms ...
Qian-qian Fan, Rong-xia He
doaj   +1 more source

AhR/IL-22 pathway as new target for the treatment of post-infectious irritable bowel syndrome symptoms

Gut Microbes, 2022
Alterations in brain/gut/microbiota axis are linked to Irritable Bowel Syndrome (IBS) physiopathology. Upon gastrointestinal infection, chronic abdominal pain and anxio-depressive comorbidities may persist despite pathogen clearance leading to Post ...
Maëva Meynier, Elodie Baudu, Nathalie Rolhion, Manon Defaye, Marjolène Straube, Valentine Daugey, Morgane Modoux, Ivan Wawrzyniak, Frédéric Delbac, Romain Villéger, Mathieu Méleine, Esther Borras Nogues, Catherine Godfraind, Nicolas Barnich, Denis Ardid, Philippe Poirier, Harry Sokol, Jean-Marc Chatel, Philippe Langella, Valérie Livrelli, Mathilde Bonnet, Frédéric Antonio Carvalho   +21 more
doaj   +1 more source

Performance and water usage of selected vegetables grown with different irrigation systems under house-type structures

Annals of Tropical Research, 2017
Irrigation for vegetables grown under protected cropping is very important for optimum production. Likewise, choosing an efficient method of irrigation can save water and labour.
Jessie C. Rom, Zenaida C. Gonzaga, Othello B. Capuno, Ana Linda G. Gorme, Warren L. Obeda, Sandra McDougall, Adam D. Goldwater, Gordon S. Rogers   +7 more
doaj   +1 more source

Growth and yield of tomato (Solanum lycopersicum L.) as influenced by different soil organic amendments and types of cultivation

Annals of Tropical Research, 2017
Tomato is one of the most profitable crops in the Philippines and is extensively cultivated throughout the world. However, its production faces different pest and disease problems, particularly bacterial wilt which greatly reduces yield.
Ana Linda G. Gorme, Zenaida C. Gonzaga, Othello B. Capuno, Jessie C. Rom, Sandra McDougall, Adam D. Goldwater, Gordon S. Rogers   +6 more
doaj   +1 more source

Kynurenine: an oncometabolite in colon cancer

Cell Stress, 2020
Tryptophan is one of the eight essential amino acids that must be obtained from the diet. Interestingly, tryptophan is the least abundant amino acid in most proteins, a large portion of cellular tryptophan is converted into metabolites of the serotonin ...
Niranjan Venkateswaran, Maralice Conacci-Sorrell   +1 more
doaj   +1 more source