Results 11 to 20 of about 98,913 (262)

Gut Microbiota-Derived Indole-3-Acetaldehyde Contributes to the Disease-Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis. [PDF]

Adv Sci (Weinh)
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Han X, Ding J, Pan Z, He W, Kang X, Zhao C, Li Y, Wu D, Li H, Ren K, Lin J, Guo J.   +11 more
europepmc   +2 more sources

Correction to "Gut Parabacteroides distasonis-Derived Indole-3-Acetic Acid Promotes Phospholipid Remodeling and Enhances Ferroptosis Sensitivity via the AhR‒FASN Axis in Bladder Cancer". [PDF]

Adv Sci (Weinh)
Advanced Science, EarlyView.
europepmc   +2 more sources

AHR and PLK1 are important for LUAD progression.

, 2023
A, Comparison of AHR and PLK1 expressions among normal lung, LUAD, LUSC, and SCLC cell lines using data from the DepMap database. Statistical methods: Welch’s ANOVA test following multiple comparisons (AHR); one-way ANOVA following multiple comparisons ...
Chi Wang (131921), Qing Shao (50505), Fengyi Mao (15073242), B. Mark Evers (351582), Sai Wu (6096290), Yanquan Zhang (14930570), Daheng He (9189701), Xiaoqi Liu (45630), Derek B. Allison (15141675), Yifan Kong (4458616), Jinghui Liu (1733008), Piotr Rychahou (563188), Xiongjian Rao (2566378), Ibrahim A. Imam (17427377), Ruixin Wang (1602244), Chaohao Li (15141681), Qiongsi Zhang (2818111), Xinyi Wang (559030), Zhiguo Li (431917)   +18 more
core   +1 more source

Interaction of AHR and PLK1 is implicated in LUAD progression.

, 2023
A, Illustration of p-AHR antibodies and validation experiments. Created with BioRender.com. B, Specificities validation of two anti-p-AHR antibodies with F3 or HA-AHR. C, IB to detect p-AHR in normal lung cells and different subtypes of lung cancers.
Chi Wang (131921), Qing Shao (50505), Fengyi Mao (15073242), B. Mark Evers (351582), Sai Wu (6096290), Yanquan Zhang (14930570), Daheng He (9189701), Xiaoqi Liu (45630), Derek B. Allison (15141675), Yifan Kong (4458616), Jinghui Liu (1733008), Piotr Rychahou (563188), Xiongjian Rao (2566378), Ibrahim A. Imam (17427377), Ruixin Wang (1602244), Chaohao Li (15141681), Qiongsi Zhang (2818111), Xinyi Wang (559030), Zhiguo Li (431917)   +18 more
core   +1 more source

Il meccanismo molecolare nella risposta cellulare alle diossine: AHR e suoi interattori [PDF]

, 2022
La proteina AhR (Aryl-hydrocarbon Receptor) è espressa in numerosi tessuti di mammifero. AhR è in grado di legare sostanze chimiche di natura antropica quali idrocarburi aromatici alogenati e policiclici o sostanze naturali di origine microbica ...
Carpentieri, Jacopo Amerigo
core  

AHR-Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg-Mediated Macrophage Efferocytosis. [PDF]

Adv Sci (Weinh)
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zhu Z, Zhang H, Lin S, Zheng W, Li X, Xu X, Yang R.   +6 more
europepmc   +2 more sources

Correlation of susceptibility to ortho-aminoazotolueneinduced hepatocarcinogenesis with Car and Ahr signaling pathway activation in mice

Вавиловский журнал генетики и селекции, 2015
Ortho-aminoazotoluene (OAT) is a potent hepatocarcinogen for most strains of mice. It has previously been shown that OAT application activates the aryl hydrocarbon receptor (Ahr) and the constitutive androstane receptor (Car) in the mouse liver.
N. V. Baginskaya, E. V. Kashina, M. Yu. Shamanina, S. I. Ilnitskaya, V. I. Kaledin, V. A. Mordvinov   +5 more
doaj   +1 more source

Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications

Cells, 2022
Target modulation of the AhR for inflammatory gastrointestinal (GI) conditions holds great promise but also the potential for safety liabilities both within and beyond the GI tract.
Samantha C. Faber, Tejas S. Lahoti, Ewan R. Taylor, Lauren Lewis, Jessica M. Sapiro, Vicencia Toledo Sales, Yvonne P. Dragan, Brandon D. Jeffy   +7 more
doaj   +1 more source

Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway [PDF]

, 2022
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating adaptive and maladaptive responses toward exogenous and endogenous signals.
Hartung, Frederick, Hätälä, Anna M, Vogel, Christoph FA, Hätälä, Anna M., Rolfes, Katharina M., Rolfes, Katharina M, Faßbender, Sonja, Vogel, Christoph F.A., Sondermann, Natalie C., Haarmann-Stemmann, Thomas, Sondermann, Natalie C   +10 more
core   +1 more source

Effect of pulmonary training for community‐dwelling frail older adults with chronic stroke: A randomized controlled pilot trial

Journal of General and Family Medicine, 2022
Background Decreased pulmonary function and poor deglutition are a major risk factor for poststroke aspiration pneumonia. We analyzed the benefits of pulmonary training on pulmonary function, deglutition, and quality of life (QOL) in community‐dwelling ...
Naoki Maki, Harumi Sakamoto, Yu Takata, Keisuke Taniguchi, Ashoka Wijesinghe, Junko Okamura, Tomoyuki Kawamura, Takahiro Yanagihara, Yusuke Saeki, Shinsuke Kitazawa, Naohiro Kobayashi, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Yukio Sato, Hisako Yanagi   +15 more
doaj   +1 more source