Uremic Toxins and Protein-Bound Therapeutics in AKI and CKD: Up-to-Date Evidence
Toxins, 2021 Uremic toxins are defined as harmful metabolites that accumulate in the human body of patients whose renal function declines, especially chronic kidney disease (CKD) patients. Growing evidence demonstrates the deteriorating effect of uremic toxins on CKD
Jia-Huang Chen, Chih-Kang Chiang
doaj +2 more sources
Toxins, 2020 Uremic vascular calcification (VC) commonly occurs during advanced chronic kidney disease (CKD) and significantly increases cardiovascular morbidity and mortality.
Chia-Ter Chao, Shih-Hua Lin
doaj +2 more sources
Uremic Toxins and Atrial Fibrillation: Mechanisms and Therapeutic Implications
Toxins, 2019 Atrial fibrillation (AF) is the most prevalent arrhythmia in the general population. There is a close association between chronic kidney disease (CKD) and AF.
Fumi Yamagami +3 more
doaj +2 more sources
ToxinsChronic kidney disease (CKD) can lead to cardiac dysfunction in a condition known as cardiorenal syndrome (CRS). It is postulated that the accumulation of uremic toxins in the bloodstream, as a consequence of declining kidney function, may contribute to ...
Heshini Dalpathadu +3 more
doaj +2 more sources
Elimination of endogenous toxin, creatinine from blood plasma depends on albumin conformation: site specific uremic toxicity & impaired drug binding. [PDF]
PLoS ONE, 2011 Uremic syndrome results from malfunctioning of various organ systems due to the retention of uremic toxins which, under normal conditions, would be excreted into the urine and/or metabolized by the kidneys.
Ankita Varshney +4 more
doaj +2 more sources
Targeting the Gut Microbial Metabolic Pathway With Small Molecules Decreases Uremic Toxin Production
Gut Microbes, 2020 Uremic toxins are a class of toxins that accumulate in patients with chronic kidney disease (CKD). Indoxyl sulfate (IS), a typical uremic toxin, is not efficiently removed by hemodialysis.
Jin-Ao Duan, Shu Jiang, Jianming Guo
exaly +2 more sources
Derivation and Elimination of Uremic Toxins From Kidney-Gut Axis
Frontiers in Physiology, 2023 Uremic toxins are chemicals, organic or inorganic, that accumulate in the body fluids of individuals with acute or chronic kidney disease and impaired renal function.
Zhiyong Guo
exaly +3 more sources
Review on Uremic Toxins: Classification, Concentration, and Interindividual Variability
Kidney International, 2003 Background. The choice of the correct concentration of potential uremic toxins for in vitro, ex vivo, and in vivo experiments remains a major area of concern; errors at this level might result in incorrect decisions regarding therpeutic correction of ...
Ziad A Massy +2 more
exaly +2 more sources
Assessment of Within- and Inter-Patient Variability of Uremic Toxin Concentrations in Children with CKD [PDF]
ToxinsTo promote improved trial design in upcoming randomized clinical trials in childhood chronic kidney disease (CKD), insight in the within- and inter-patient variability of uremic toxins with its nutritional, treatment- and patient-related confounding ...
Evelien Snauwaert +11 more
doaj +2 more sources
A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients [PDF]
Toxins, 2019 Hydrophobic uremic toxins accumulate in patients with chronic kidney disease, contributing to a highly increased cardiovascular risk. The clearance of these uremic toxins using current hemodialysis techniques is limited due to their hydrophobicity and ...
Marieke Sternkopf +12 more
doaj +2 more sources