Results 11 to 20 of about 151,121 (186)
Future of Uremic Toxin Management
ToxinsDuring the progression of chronic kidney disease (CKD), the retention of uremic toxins plays a key role in the development of uremic syndrome. Knowledge about the nature and biological impact of uremic toxins has grown exponentially over the past decades.
Raymond Vanholder +3 more
doaj +5 more sources
Parathyroid Hormone: A Uremic Toxin [PDF]
Toxins, 2020 Parathyroid hormone (PTH) has an important role in the maintenance of serum calcium levels. It activates renal 1α-hydroxylase and increases the synthesis of the active form of vitamin D (1,25[OH]2D3).
Eduardo J. Duque +2 more
doaj +4 more sources
From Physicochemical Classification to Multidimensional Insights: A Comprehensive Review of Uremic Toxin Research [PDF]
ToxinsChronic kidney disease (CKD) is a global health burden, with uremic toxins (UTs) playing a central role in its pathophysiology. In this review, we systematically examined the evolution of UT classification from the 2003 European Uremic Toxin Work Group ...
Mario Cozzolino +2 more
doaj +2 more sources
Gut-Derived Protein-Bound Uremic Toxins
Toxins, 2020 Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of the fastest growing global causes of mortality. When glomerular filtration rate begins to fall, uremic toxins accumulate in the serum and significantly increase ...
Amanda L Graboski, Matthew R. Redinbo
exaly +2 more sources
Toxins, 2016 N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new ...
Aurélie Lenglet +10 more
doaj +2 more sources
Targeting Uremic Toxins to Prevent Peripheral Vascular Complications in Chronic Kidney Disease
Toxins, 2020 Chronic kidney disease (CKD) exhibits progressive kidney dysfunction and leads to disturbed homeostasis, including accumulation of uremic toxins, activated renin-angiotensin system, and increased oxidative stress and proinflammatory cytokines.
Chia-Lin Wu, Der-Cherng Tarng
doaj +2 more sources
Uremic Toxin Clearance and Cardiovascular Toxicities
Toxins, 2018 Uremic solutes contribute to cardiovascular disease in renal insufficiency. In this review we describe the clearance of selected uremic solutes, which have been associated with cardiovascular disease.
Robert D. Mair +2 more
doaj +2 more sources
Uremic Toxins and Cardiovascular System [PDF]
Cardiology Clinics, 2021 When chronic kidney disease develops, the capacity of the kidneys to clear metabolic waste products from the body is gradually lost. This process results in the retention of a large array of compounds affecting biochemical and biological functions (uremic toxins), of which several can cause cardiovascular damage.
Valkenburg, Sophie +2 more
openaire +3 more sources
Critical Care Explorations, 2021 OBJECTIVES:. Shiga toxin-producing Escherichia coli infection is associated with dysentery and the hemolytic uremic syndrome, marked by the triad of microangiopathic hemolytic anemia, acute kidney failure, and thrombocytopenia.
Charles G. Volk, MD +4 more
doaj +1 more source
The removal of uremic toxins [PDF]
Kidney International, 2000 Three major groups of uremic solutes can be characterized: the small water-soluble compounds, the middle molecules, and the protein-bound compounds. Whereas small water-soluble compounds are quite easily removed by conventional hemodialysis, this is not the case for many other molecules with different physicochemical characteristics.
Dhondt, Annemieke +3 more
openaire +2 more sources