Results 11 to 20 of about 25,775 (238)
Targeting the gut microbial metabolic pathway with small molecules decreases uremic toxin production
Gut Microbes, 2020 Uremic toxins are a class of toxins that accumulate in patients with chronic kidney disease (CKD). Indoxyl sulfate (IS), a typical uremic toxin, is not efficiently removed by hemodialysis.
Yingyi Wang +10 more
doaj +2 more sources
Parathyroid Hormone: A Uremic Toxin [PDF]
Toxins, 2020 Parathyroid hormone (PTH) has an important role in the maintenance of serum calcium levels. It activates renal 1α-hydroxylase and increases the synthesis of the active form of vitamin D (1,25[OH]2D3).
Eduardo J. Duque +2 more
doaj +3 more sources
Toxins, 2016 N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new ...
Aurélie Lenglet +10 more
doaj +3 more sources
Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate
Toxins, 2014 Protein binding prevents uremic toxins from removal by conventional extracorporeal therapies leading to accumulation in maintenance dialysis patients. Weakening of the protein binding may enhance the dialytic elimination of these toxins.
Eric Devine +4 more
doaj +3 more sources
Uremic Toxins and Cardiovascular System [PDF]
Cardiology Clinics, 2021 When chronic kidney disease develops, the capacity of the kidneys to clear metabolic waste products from the body is gradually lost. This process results in the retention of a large array of compounds affecting biochemical and biological functions (uremic toxins), of which several can cause cardiovascular damage.
Valkenburg, Sophie +2 more
openaire +3 more sources
Journal of Medical Case Reports, 2021 Background Cardiac and neurological involvement in hemolytic uremic syndrome are life-threatening complications. The most frequent complications of cardiac involvement in hemolytic uremic syndrome are myocarditis and cardiac dysfunction due to fluid ...
Sophie Mounier +5 more
doaj +1 more source
Toxins, 2022 Sodium–glucose cotransporter (SGLT) inhibitors are a class of oral hypoglycemic agents, which, in recent years, have been shown to improve renal and cardiovascular outcomes in patients with diabetic and non-diabetic chronic kidney disease.
Pieter Evenepoel +3 more
doaj +1 more source
Derivation and elimination of uremic toxins from kidney-gut axis
Frontiers in Physiology, 2023 Uremic toxins are chemicals, organic or inorganic, that accumulate in the body fluids of individuals with acute or chronic kidney disease and impaired renal function.
Ying Xu +7 more
doaj +1 more source
The Dual Roles of Protein-Bound Solutes as Toxins and Signaling Molecules in Uremia
Toxins, 2022 In patients with severe kidney disease, renal clearance is compromised, resulting in the accumulation of a plethora of endogenous waste molecules that cannot be removed by current dialysis techniques, the most often applied treatment.
Rosalinde Masereeuw
doaj +1 more source
Uremic Pruritus: From Diagnosis to Treatment
Diagnostics, 2022 Uremic pruritus, or chronic kidney disease-associated pruritus, is common, bothersome, and sometimes debilitating in patients with chronic kidney disease or end-stage renal disease.
An-Yu Cheng, Lai-San Wong
doaj +1 more source