Results 31 to 40 of about 151,121 (186)

Uremic Toxins in Organ Crosstalk [PDF]

Frontiers in Medicine, 2021
Many putative uremic toxins—like indoxyl sulfate, p-cresol sulfate, kynurenic acid, uric acid, and CMPF—are organic anions. Both inter-organ and inter-organismal communication are involved. For example, the gut microbiome is the main source of indole, which, after modification by liver drug metabolizing enzymes (DMEs), becomes indoxyl sulfate.
Jerome Lowenstein, Sanjay K. Nigam
openaire   +3 more sources

Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate [PDF]

, 2014
Protein binding prevents uremic toxins from removal by conventional extracorporeal therapies leading to accumulation in maintenance dialysis patients. Weakening of the protein binding may enhance the dialytic elimination of these toxins.
Devine, Eric, Eric Devine, Joachim Jankovski, Detlef Krieter, Rüth, Marieke, Lemke, Horst-Dieter, Jankovski, Joachim, Marieke Rüth, Horst-Dieter Lemke, Krieter, Detlef H., Detlef H. Krieter   +10 more
core   +1 more source

The role of EUTox in uremic toxin research

, 2009
In this publication, we review the activities of the European Uremic Toxin Work Group (EUTox) in the field of uremic toxin research. Founded in 1999 under the umbrella of the European Society of Artificial Organs (ESAO), and active since 2000, this group
Wanner, Christoph, Baurmeister, U, De Deyn, PP, Glorieux, Griet, Drueke, TB, Argiles, A, Stenvinkel, Peter, Stenvinkel, P, Brunet, Philippe, Wiecek, Andrzej, Thornalley, PJ, Abou-Deif, Omar, Drüeke, Tilman B, Vanholder, Raymond, Massy, Ziad A., Herget-Rosenthal, S, Jorres, A, Rodriguez-Portillo, Juan Mariano, Beige, Joachim, Stegmayr, Bernd G,, Thornalley, Paul J, Stegmayr, Bernd G., Mischak, Harald, Spasovski, Goce, Argiles, Angel, Jankowski, J, Drüeke, Tilman B., Brouckaert, Peter, Fliser, Danilo, Jörres, Achim, Thornalley, Paul J., Hörl, Walter H, Massy, ZA, Perna, Alessandra F., Horl, WH, Cohen, G, Mischak, H, Fliser, D, Jankowski, Joachim, Cohen, Gerald, Wanner, C, Massy, Ziad A, Stegmayr, BG, Abou-Deif, O, Perna, Alessandra F, Herget-Rosenthal, Stefan, Perna, AF, Baurmeister, Ulrich, Spasovski, G, Rodriguez-Portillo, JM, Wiecek, A, De Deyn, Peter Paul, Beige, J, BROUCKAERT P, JÖRRES A, De, Deyn PP, HERGET ROSENTHAL S, HÖRL WH, ARGILES A, WANNER C, WIECEK A., VANHOLDER R, ABOU DEIF O, PERNA, Alessandra, FLISER D, STEGMAYR BG, et al., COHEN G, BRUNET P, MASSY ZA, THORNALLEY PJ, BEIGE J, Vanholder, R, SPASOVSKI G, GLORIEUX G, DE DEYN PP, DRÜEKE TB, RODRIGUEZ PORTILLO JM, BAURMEISTER U, MISCHAK H, JANKOWSKI J, Brunet, P, Brouckaert, P, STENVINKEL P, Danilo Fliser, Joachim Jankowski, Griet Glorieux, Walter H Hörl, Peter Brouckaert, Peter Paul De Deyn, Ulrich Baurmeister, Omar Abou-Deif, Philippe Brunet, Tilman B. Drüeke, Joachim Beige, Hoerl, Walter H., Goce Spasovski, Joerres, Achim, Mariano Rodriguez-Portillo, Juan, Alessandra F. Perna, Bernd G. Stegmayr, Andrzej Wiecek, Angel Argiles, Peter Stenvinkel, Juan Mariano Rodriguez-Portillo, Gerald Cohen, Achim Jörres, Ziad A. Massy, Stefan Herget-Rosenthal, Drueeke, Tilman B., Christoph Wanner, Raymond Vanholder, Harald Mischak, Paul J. Thornalley   +113 more
core   +3 more sources

Hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli in a renal transplant recipient case report

Brazilian Journal of Nephrology, 2020
Thrombotic microangiopathies are disorders characterized by nonimmune microangiopathic hemolytic anemia, thrombocytopenia, and multi-systemic failure.
John Fredy Nieto-Rios, Monica Zuluaga-Quintero, Julio Cesar Valencia-Maturana, Diana Carolina Bello-Marquez, Arbey Aristizabal-Alzate, Gustavo Adolfo Zuluaga-Valencia, Lina Maria Serna-Higuita, Luis Fernando Arias   +7 more
doaj   +2 more sources

Uremic Toxins and Vascular Dysfunction [PDF]

Toxins, 2020
Vascular dysfunction is an essential element found in many cardiovascular pathologies and in pathologies that have a cardiovascular impact such as chronic kidney disease (CKD). Alteration of vasomotricity is due to an imbalance between the production of relaxing and contracting factors. In addition to becoming a determining factor in pathophysiological
Six, I., Flissi, Nadia, Lenglet, Gaëlle, Louvet, Loïc, Kamel, Saïd, Gallet, Marlène, Massy, Ziad, Liabeuf, Sophie   +7 more
openaire   +5 more sources

Baseline uremic toxin concentrations as predictors of eGFR decline.

, 2016
Baseline uremic toxin concentrations as predictors of eGFR decline.
Petra H. van den Broek (587366), Jan A. J. G. van den Brand (3607550), Peter J. Blankestijn (151363), Frans G. M. Russel (225673), Rosalinde Masereeuw (180563), Jack F. M. Wetzels (151358), Henricus A. M. Mutsaers (225665), Arjan D. van Zuilen (3607547)   +7 more
core   +1 more source

Protein/Fiber Index Modulates Uremic Toxin Concentrations in Hemodialysis Patients

, 2022
Background: Indoxyl sulfate (IS) and p-cresyl sulfate (PCS), two uremic toxins (UTs), are associated with increased mortality in patients with chronic kidney disease (CKD).
Cecilia Mallmann, Bouchouareb, Dammar, Manon Ebersolt, Mc-Kay, Nathalie, Dou, Laetitia, Nathalie Mc-Kay, Marion Sallée, Santana Machado, Tacy, Tacy Santana Machado, Laetitia Dou, Mallmann, Cecilia, Philippe Brunet, Stéphane Burtey, Brunet, Philippe, Sallée, Marion, Dammar Bouchouareb, Ebersolt, Manon, Burtey, Stéphane   +17 more
core   +1 more source

Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor

Cellular & Molecular Biology Letters
Aryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed that AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the ...
Hongyan Xie, Ninghao Yang, Chen Yu, Limin Lu   +3 more
doaj   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source