Results 51 to 60 of about 27,152 (233)

Metabolic profiling of human plasma and urine in chronic kidney disease by hydrophilic interaction liquid chromatography coupled with time-of-flight mass spectrometry : a pilot study [PDF]

, 2017
A typical characteristic of chronic kidney disease (CKD) is the progressive loss in renal function over a period of months or years with the concomitant accumulation of uremic retention solutes in the body.
Boelaert, Jente, Glorieux, Griet, Lynen, Frederic, Neirynck, Nathalie, Schepers, Eva, Vanholder, Raymond   +5 more
core   +1 more source

Modeling Uremic Vasculopathy With Induced Pluripotent Stem Cell-Derived Endothelial Cells as a Drug Screening System

Frontiers in Cell and Developmental Biology, 2021
Background: Cardiovascular complications are the leading cause of mortality in patients with chronic kidney disease (CKD). Uremic vasculopathy plays a crucial role in facilitating the progression of cardiovascular complications in advanced CKD.
Hye Ryoun Jang, Hyung Joon Cho, Yang Zhou, Ning-Yi Shao, Kyungho Lee, Hoai Huong Thi Le, Junseok Jeon, Jung Eun Lee, Wooseong Huh, Sang-Ging Ong, Sang-Ging Ong, Won Hee Lee, Yoon-Goo Kim   +12 more
doaj   +1 more source

Chronic Kidney Disease Increases Cerebral Microbleeds in Mouse and Man. [PDF]

, 2020
Brain microbleeds are increased in chronic kidney disease (CKD) and their presence increases risk of cognitive decline and stroke. We examined the interaction between CKD and brain microhemorrhages (the neuropathological substrate of microbleeds) in ...
Bangash, Maria, Cribbs, David H, Fisher, Mark, Floriolli, David, Lau, Wei Ling, Lertpanit, Long, Naqvi, Sameen, Nunes, Ane CF, Paganini-Hill, Annlia, Savoj, Javad, Shah, Krunal, Vasilevko, Vitaly, Vaziri, Nosratola D, Yao, Zhihui   +13 more
core  

The Microbiome and Uremic Solutes

Toxins, 2022
Uremic retention solutes, especially the protein-bound compounds, are toxic metabolites, difficult to eliminate with progressive renal functional decline.
Nadim Zaidan, Lama Nazzal
doaj   +1 more source

Uraemic toxins and new methods to control their accumulation : game changers for the concept of dialysis adequacy [PDF]

, 2015
The current concept of an adequate dialysis based only on the dialysis process itself is rather limited. We now have considerable knowledge of uraemic toxicity and improved tools for limiting uraemic toxin accumulation. It is time to make use of these. A
Glorieux, Griet, Tattersall, James
core   +2 more sources

Parathyroid Hormone: A Uremic Toxin [PDF]

Toxins, 2020
Parathyroid hormone (PTH) has an important role in the maintenance of serum calcium levels. It activates renal 1α-hydroxylase and increases the synthesis of the active form of vitamin D (1,25[OH]2D3). PTH promotes calcium release from the bone and enhances tubular calcium resorption through direct action on these sites.
Eduardo J. Duque, Rosilene M. Elias, Rosa M. A. Moysés   +2 more
openaire   +3 more sources

Comprehensive Bibliometric Analysis of Uremic Toxin Research

Toxins
Uremic toxins accumulate as kidney disease progresses, contributing to diverse systemic disorders. Despite numerous studies, no comprehensive mapping has been performed.
Marsuki Hardjo, Takuya Wakamatsu, Kazuki Watanabe, Shoko Yamazaki, Suguru Yamamoto   +4 more
doaj   +1 more source

Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]

, 2018
Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean, Halliday, Christopher, Jahagirdar, Ravi, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Robson, Richard, Stotz, Stephanie C, Sweeney, Michael, Tsujikawa, Laura M, Wasiak, Sylwia, Wong, Norman C   +11 more
core   +2 more sources

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source

The intestine and the kidneys : a bad marriage can be hazardous [PDF]

, 2015
The concept that the intestine and chronic kidney disease influence each other, emerged only recently. The problem is multifaceted and bidirectional. On one hand, the composition of the intestinal microbiota impacts uraemic retention solute production ...
Glorieux, Griet, Vanholder, Raymond
core   +1 more source