Results 51 to 60 of about 116,102 (224)

New insights in uremic toxins [PDF]

Kidney International, 2003
The retention in the body of compounds, which normally are secreted into the urine results in a clinical picture, called the uremic syndrome. The retention compounds responsible for the uremic syndrome are called uremic toxins. Only a few of the uremic retention solutes fully conform to a true definition of uremic toxins.
Vanholder, Raymond, Glorieux, Griet, De Smet, Rita, Lameire, Norbert   +3 more
openaire   +2 more sources

Microbial Modulation of a Uremic Toxin [PDF]

Cell Host & Microbe, 2016
In this issue of Cell Host & Microbe, Devlin et al. (2016) identify a family of tryptophanases encoded by members of the human gut microbiome and demonstrate that levels of the uremic toxin indoxyl sulfate can be modulated in vivo by altering the abundance of bacteria harboring tryptophanase activity.
Sarah M, Skye, Stanley L, Hazen
openaire   +2 more sources

Comprehensive Bibliometric Analysis of Uremic Toxin Research

Toxins
Uremic toxins accumulate as kidney disease progresses, contributing to diverse systemic disorders. Despite numerous studies, no comprehensive mapping has been performed.
Marsuki Hardjo, Takuya Wakamatsu, Kazuki Watanabe, Shoko Yamazaki, Suguru Yamamoto   +4 more
doaj   +1 more source

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, EarlyView.
Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Gut-Derived Metabolites and Their Role in Immune Dysfunction in Chronic Kidney Disease

Toxins, 2020
Several of the uremic toxins, which are difficult to remove by dialysis, originate from the gut bacterial metabolism. This opens opportunities for novel targets trying to decrease circulating levels of these toxins and their pathophysiological effects ...
Griet Glorieux, Tessa Gryp, Alessandra Perna   +2 more
doaj   +1 more source

Parathyroid Hormone: A Uremic Toxin [PDF]

Toxins, 2020
Parathyroid hormone (PTH) has an important role in the maintenance of serum calcium levels. It activates renal 1α-hydroxylase and increases the synthesis of the active form of vitamin D (1,25[OH]2D3). PTH promotes calcium release from the bone and enhances tubular calcium resorption through direct action on these sites.
Eduardo J. Duque, Rosilene M. Elias, Rosa M. A. Moysés   +2 more
openaire   +3 more sources

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor

Cellular & Molecular Biology Letters
Aryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed that AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the ...
Hongyan Xie, Ninghao Yang, Chen Yu, Limin Lu   +3 more
doaj   +1 more source

Dicarboxymethyl Cellulose‐Based Mixed‐Matrix Membrane Adsorbers: Preparation, Characterization, and Protein Retention Performance

Journal of Applied Polymer Science, EarlyView.
Dicarboxymethyl cellulose is incorporated, for the first time, into a polyethersulfone membrane. The functional membranes are prepared using dimethyl isosorbide through combined non‐solvent and vapor‐induced phase separation. The resulting membranes exhibit porous structures and protein‐retention potential, highlighting the potential of this cellulose ...
Diana Gago, Giuseppe Di Luca, Francesca Russo, Ricardo Chagas, Luísa Maria Ferreira, Francesco Galiano, Isabel Coelhoso, Alberto Figoli   +7 more
wiley   +1 more source