Results 41 to 50 of about 27,152 (233)
Prebiotic, Probiotic, and Synbiotic Supplementation in Chronic Kidney Disease: A Systematic Review and Meta-analysis [PDF]
, 2019 Gut dysbiosis has been implicated in the pathogenesis of chronic kidney disease (CKD). Restoring gut microbiota with prebiotic, probiotic, and synbiotic supplementation has emerged as a potential therapeutic intervention but has not been systematically ...
Campbell, Katrina L. +3 more
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Uremic Toxins and Vascular Dysfunction [PDF]
Toxins, 2020 Vascular dysfunction is an essential element found in many cardiovascular pathologies and in pathologies that have a cardiovascular impact such as chronic kidney disease (CKD). Alteration of vasomotricity is due to an imbalance between the production of relaxing and contracting factors. In addition to becoming a determining factor in pathophysiological
Isabelle Six +7 more
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Toxins, 2020 Uremic vascular calcification (VC) commonly occurs during advanced chronic kidney disease (CKD) and significantly increases cardiovascular morbidity and mortality.
Chia-Ter Chao, Shih-Hua Lin
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Toxins, 2023 During the past decades, the gut microbiome emerged as a key player in kidney disease. Dysbiosis-related uremic toxins together with pro-inflammatory mediators are the main factors in a deteriorating kidney function.
Gianvito Caggiano +8 more
doaj +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2014 PURPOSE. Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs ...
Toshihiro Sato +4 more
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Role of Uremic Toxins in Early Vascular Ageing and Calcification
Toxins, 2021 In patients with advanced chronic kidney disease (CKD), the accumulation of uremic toxins, caused by a combination of decreased excretion secondary to reduced kidney function and increased generation secondary to aberrant expression of metabolite genes ...
Nikolaos C. Kyriakidis +4 more
doaj +1 more source
'Uremic toxin' section in the journal Toxins : a powerful tool to bundle and advance knowledge on uremia [PDF]
, 2017 In the journal Toxins, a new section has been added to those already included, which will be specifically devoted to uremic toxins.[...
Vanholder, Raymond
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The removal of uremic toxins [PDF]
Kidney International, 2000 Three major groups of uremic solutes can be characterized: the small water-soluble compounds, the middle molecules, and the protein-bound compounds. Whereas small water-soluble compounds are quite easily removed by conventional hemodialysis, this is not the case for many other molecules with different physicochemical characteristics.
Dhondt, Annemieke +3 more
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Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3. [PDF]
PLoS ONE, 2013 The accumulated uremic toxins inhibit the expression of various renal transporters and this inhibition may further reduce renal function and subsequently cause the accumulation of uremic toxins.
Yasutoshi Akiyama +17 more
doaj +1 more source
New insights in uremic toxins [PDF]
Kidney International, 2003 The retention in the body of compounds, which normally are secreted into the urine results in a clinical picture, called the uremic syndrome. The retention compounds responsible for the uremic syndrome are called uremic toxins. Only a few of the uremic retention solutes fully conform to a true definition of uremic toxins.
Vanholder, Raymond +3 more
openaire +2 more sources