Results 41 to 50 of about 116,102 (224)

Carbamoylated nail proteins as assessed by near-infrared analysis are associated with load of uremic toxins and mortality in hemodialysis patients [PDF]

, 2020
Carbamoylation is an important risk factor for accelerated atherogenesis and mortality in patients undergoing hemodialysis (HD). We intended to explore whether carbamoylation as assessed by near-infrared (NIR) analysis of nail proteins is associated with
Jonas Himpe, Himpe, Jonas, Griet Glorieux, Marijn M. Speeckaert, Glorieux, Griet, Van Biesen, Wim, De Buyzere, Marc, Sigurd E. Delanghe, Wim Van Biesen, De Bruyne, Sander, Marc L. De Buyzere, Joris R. Delanghe, Sander De Bruyne, Delanghe, Sigurd, Speeckaert, Marijn, Delanghe, Joris   +15 more
core   +1 more source

Effect of uremic toxins on hippocampal cell damage: analysis in vitro and in rat model of chronic kidney disease

Heliyon, 2021
One third of the patients with chronic kidney disease (CKD) develop cognitive impairment, which is also an independent risk factor for mortality. However, the concise mechanism of cerebro-renal interaction has not been clarified.
Kimio Watanabe, Emiko Sato, Eikan Mishima, Mayu Watanabe, Takaaki Abe, Nobuyuki Takahashi, Masaaki Nakayama   +6 more
doaj   +1 more source

Uremic Toxins Enhance Statin-Induced Cytotoxicity in Differentiated Human Rhabdomyosarcoma Cells

Toxins, 2014
The risk of myopathy and rhabdomyolysis is considerably increased in statin users with end-stage renal failure (ESRF). Uremic toxins, which accumulate in patients with ESRF, exert cytotoxic effects that are mediated by various mechanisms.
Hitoshi Uchiyama, Masayuki Tsujimoto, Tadakazu Shinmoto, Hitomi Ogino, Tomoko Oda, Takuya Yoshida, Taku Furukubo, Satoshi Izumi, Tomoyuki Yamakawa, Hidehisa Tachiki, Tetsuya Minegaki, Kohshi Nishiguchi   +11 more
doaj   +1 more source

Uremic Toxins and Blood Purification: A Review of Current Evidence and Future Perspectives

, 2021
Accumulation of uremic toxins represents one of the major contributors to the rapid progression of chronic kidney disease (CKD), especially in patients with end-stage renal disease that are undergoing dialysis treatment.
Stefania Magnani, Mauro Atti
core   +1 more source

Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives

Toxins, 2023
During the past decades, the gut microbiome emerged as a key player in kidney disease. Dysbiosis-related uremic toxins together with pro-inflammatory mediators are the main factors in a deteriorating kidney function.
Gianvito Caggiano, Alessandra Stasi, Rossana Franzin, Marco Fiorentino, Maria Teresa Cimmarusti, Annamaria Deleonardis, Rita Palieri, Paola Pontrelli, Loreto Gesualdo   +8 more
doaj   +1 more source

Probiotic Supplementation in Chronic Kidney Disease: Outcomes on Uremic Toxins, Inflammation, and Vascular Calcification from Experimental and Clinical Models. [PDF]

Toxins (Basel)
Chronic kidney disease (CKD) is associated with gut microbiota alterations that contribute to increased inflammation and the generation of uremic toxins and may worsen the disease progression.
Obrero T, Pendón-Ruiz de Mier MV, Gordillo-Arnaud JE, Jiménez Moral MJ, Vidal V, Guerrero F, Carmona A, Rodríguez-Ortiz ME, Torralbo AI, Ojeda R, Moyano C, Sanchez-Ramade M, Mesa J, López-Ruiz DJ, Valdés-Díaz K, García-Sáez RM, Jurado-Montoya D, Rodelo-Haad C, Álvarez-Benito M, Glorieux G, Rodríguez M, Soriano-Cabrera S, Muñoz-Castañeda JR.   +22 more
europepmc   +2 more sources

The Medium Cut-Off Membrane Does Not Lower Protein-Bound Uremic Toxins

, 2022
The accumulation of protein-bound uremic toxins (PBUT) is associated with increased cardiovascular outcomes in patients on dialysis. However, the efficacy of PBUT removal for a medium-cutoff (MCO) membrane has not been clarified.
Jo, Young-Il, Lee, Sang Ho, Jin, KyuBok, Ju Young Moon, Sang Ho Lee, Lim, Hyun Ji, Young-Il Jo, Jung, Gun Tae, Gun Tae Jung, Kim, Kwang Pyo, Kim, Yang Gyun, Su Woong Jung, Jung, Su Woong, Hyun Ji Lim, Kwang Pyo Kim, KyuBok Jin, Moon, Ju Young, Yang Gyun Kim   +17 more
core   +1 more source

Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3. [PDF]

PLoS ONE, 2013
The accumulated uremic toxins inhibit the expression of various renal transporters and this inhibition may further reduce renal function and subsequently cause the accumulation of uremic toxins.
Yasutoshi Akiyama, Koichi Kikuchi, Daisuke Saigusa, Takehiro Suzuki, Yoichi Takeuchi, Eikan Mishima, Yasuaki Yamamoto, Ayako Ishida, Daiki Sugawara, Daisuke Jinno, Hisato Shima, Takafumi Toyohara, Chitose Suzuki, Tomokazu Souma, Takashi Moriguchi, Yoshihisa Tomioka, Sadayoshi Ito, Takaaki Abe   +17 more
doaj   +1 more source

Organic Anion Transporting Polypeptides 1B1 and 1B3 Play an Important Role in Uremic Toxin Handling and Drug-Uremic Toxin Interactions in the Liver

Journal of Pharmacy & Pharmaceutical Sciences, 2014
PURPOSE. Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs ...
Toshihiro Sato, Hiroaki Yamaguchi, Takuma Kogawa, Takaaki Abe, Nariyasu Mano   +4 more
doaj   +1 more source

Modeling Uremic Vasculopathy With Induced Pluripotent Stem Cell-Derived Endothelial Cells as a Drug Screening System

Frontiers in Cell and Developmental Biology, 2021
Background: Cardiovascular complications are the leading cause of mortality in patients with chronic kidney disease (CKD). Uremic vasculopathy plays a crucial role in facilitating the progression of cardiovascular complications in advanced CKD.
Hye Ryoun Jang, Hyung Joon Cho, Yang Zhou, Ning-Yi Shao, Kyungho Lee, Hoai Huong Thi Le, Junseok Jeon, Jung Eun Lee, Wooseong Huh, Sang-Ging Ong, Sang-Ging Ong, Won Hee Lee, Yoon-Goo Kim   +12 more
doaj   +1 more source