Results 101 to 110 of about 4,043,673 (303)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 Objective To investigate the diagnostic value of expression level of serum cystatin C (Cys-C) on early diagnosis of newly diagnosed Parkinson's disease with mild cognitive impairment (PD-MCI).
Can-can MA +9 more
doaj
Chern-Simons theory on spherical Seifert manifolds, topological strings and integrable systems
, 2015 We consider the Gopakumar-Ooguri-Vafa correspondence, relating ${\rm U}(N)$ Chern-Simons theory at large $N$ to topological strings, in the context of spherical Seifert 3-manifolds. These are quotients $\mathbb{S}^{\Gamma} = \Gamma\backslash\mathbb{S}^3$
Borot, Gaetan, Brini, Andrea
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
AerospaceThis study focuses on high-cycle fatigue (HCF) of aircraft landing gear (LG) components, covering material testing, full-scale component experiments, finite element (FE) modeling, life-prediction comparison, and probabilistic assessment.
Haihong Tang +5 more
doaj +1 more source
Lipidome profiles of postnatal day 2 vaginal swabs reflect fat composition of gilt's postnatal diet.
PLoS ONE, 2019 We hypothesized that postnatal development of the vagina is impacted by early nutritional environment. Our objective was to determine if lipid profiles of vaginal swabs were different between postnatal gilts suckled by sow or fed milk replacer the first ...
KaLynn Harlow +4 more
doaj +1 more source
Maximum likelihood method based on specimen information reconstruction and life equivalent principle for P-S-N curve fitting [PDF]
, 2020 Wenfei Liu +4 more
openalex +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source