Results 71 to 80 of about 18,455,093 (146)

Synthesis of Elastic Metallic Nickel by Solvent‐Ligand‐Mediated Reductive Assembly

Advanced Science, Volume 12, Issue 38, October 13, 2025.
The novel elastic metallic nickel, featuring ligands coordinating on the metal surface, is synthesized via rational selection of reduction and structure‐directing organic solvents. Moreover, by modulating solvent composition and incorporating acetic acid ligands, sufficient ligands are enabled to coordinate with the metal surface, thereby improving the
Haiyan An, Guoying Tan, Pingru Su, Yu Long, Deyan He, Yu Tang   +5 more
wiley   +1 more source

Developing a quantitative structure–property relationships (QSPR) model using Caco‐2 cell bioavailability indicators (BA) to predict the BA of phytochemicals

Journal of the Science of Food and Agriculture, Volume 105, Issue 12, Page 6850-6861, September 2025.
Abstract BACKGROUND The present study aimed to measure bioavailability (BA) indicators, including epithelial barrier function, apparent permeability (Papp) and efflux ratio, of 84 types of phytochemicals using Caco‐2 cell and to develop predictive model systems using machine learning with a quantitative structure–property relationship (QSPR) model ...
Kang‐Woo Lee, Dong‐Ho Lee, In‐Su Na, Jin‐Woo Kim, Na‐Yeon Lee, Jin‐Soo Park, Keunwan Park, Chau Hoang Bao Nguyen, Kyungsu Kang, Soon‐Mi Shim   +9 more
wiley   +1 more source

The mammalian metabolism of R-(-)-m-synephrine

, 1983
The metabolism of R-(-)-m-synephrine (administered orally and by inhalation in man and intraperitoneally in rats) was studied quantitatively by a gas chromatography-mass spectrometry-selected ion monitoring (g.c.–m.s.–s.i.m.) method using deuterated ...
Jan R Crowley, Clyde M Williams, Kamal E Ibrahim, John M Midgley   +3 more
core   +1 more source

Synephrine Analogues as Glucocorticoid Receptor Agonists

, 2023
This work carried out the synthesis of several new synephrine analogues by universal method. Some of the synthesized compounds showed cytotoxicity on myeloid leukaemia cells K562 and lymphoma cell line Granta-519.
Lyubov Grebenkina, Eugenia Oleynik, Ekaterina Zhidkova, Andrey Valerevich Matveev, Diana Grigoreva, Ekaterina Mikhina, Varvara Maksimova, Ekaterina Lesovaya, Marianna Yakubovskaya   +8 more
core   +1 more source

Non-invasive assessment of proarrhythmic risks associated with isoprenaline and the dietary supplement ingredient synephrine using human induced pluripotent stem cell-derived cardiomyocytes

Frontiers in Cardiovascular Medicine
BackgroundThere have been conflicting reports about the proarrhythmic risk of p-synephrine (SYN). To address this, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) combined with the microelectrode array (MEA) system have been ...
Xin Yuan, Tingting Yu, Zhang Zhang, Sen Li   +3 more
doaj   +1 more source

Synephrine Inhibits Eotaxin-1 Expression via the STAT6 Signaling Pathway

, 2014
Citrus contain various flavonoids and alkaloids that have multiple biological activities. It is known that the immature Citrus contains larger amounts of bioactive components, than do the mature plants. Although Citrus flavonoids are well known for their
Il-Hyun Kim, Jung-A Lee, Deokhoon Park, Kyung-Baeg Roh, Myungjae Lee, Young-Soo Kim, Eunsun Jung   +6 more
core   +1 more source

Metabolites of intestinal fora can be used as diagnostic and progressive markers for mild cognitive impairment

Frontiers in Cellular and Infection Microbiology
PurposeThe aim of the work was to analyze the metabolites of the intestinal microbiota from the patients with mild cognitive impairment (MCI) and progressive MCI due to Alzheimer’s disease (AD).MethodTwo cohorts were established.
Liquan Lu, Lei Qin, Xiaohui Zhao, Zanhua Liu, Xiaoting Qiu, Shuo Yang, Haihan Song, Haihan Song, Juan Yang   +8 more
doaj   +1 more source

Pharmacological Effects and Molecular Mechanism of Synephrine Hydrochloride [PDF]

Synephrine hydrochloride, an alkaloid compound extracted from immature bitter orange, has many pharmacological effects such as anticancer effect, antioxidant effect and antidepression effect.
Wang, Anqi, Quan, Quan, Chen, Hai, Wang, Jingchao, Jin, Chenghao, Wang, Mingxinzhi   +5 more
core   +1 more source

Enantioselective LC analysis of synephrine in natural products on a protein-based chiral stationary phase

, 2005
An enantioselective LC method with photodiode array detection (PAD) was developed for the enantioseparation of synephrine from C. aurantium L. var.
BENVENUTI, Stefania, MELEGARI, Michele, PELLATI, Federica   +2 more
core   +1 more source

Effect of Chronic Dolutegravir Administration on the Trace Amine Profile in Wistar Rats

Drugs in R&D
Background Dolutegravir (DTG), an integrase strand inhibitor, is currently used as the first-line treatment for HIV. Despite relatively poor tissue penetration, the risk of adverse effects in metabolic and excretory systems should be considered.
Natasha Henning, Tracy A. Kellermann, Carine Smith   +2 more
doaj   +1 more source