An evaluation of p–y curves for fatigue analysis of offshore piles and conductors
The paper evaluates methods for deriving p–y curves for fatigue analysis of slender piles and conductors. Updated ISO standard guidance is compared to a new approach, which is validated by centrifuge tests and based on laboratory measurements of ...
Watson, P. G., White, D. J., Guevara, M.
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Study on P-Y Curve Parameters of Large-Diameter Rock-Socketed Pile Under Lateral Load
Response of large-diameter rock-socketed piles subjected to lateral loads is a critical issue in foundation design for bridges, high-rise buildings, and offshore platforms.
Feng Xu +4 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
x-y duality in topological recursion for exponential variables via quantum dilogarithm
For a given spectral curve, the theory of topological recursion generates two different families $\omega_{g,n}$ and $\omega_{g,n}^\vee$ of multi-differentials, which are for algebraic spectral curves related via the universal $x-y$ duality formula.
Alexander Hock
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
P-Y Curves for Rigid Walls Retaining Granular Soil [PDF]
Salah Sadek Mounir Mabsout Jacques Harb Fadi Hage ChehadeThe mobilization of lateral stresses behind retaining walls constitutes a typical soil structure interaction problem particularly under cyclic loading conditions.
El Chiti, Imad
core
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
On the projective normality of Artin-Schreier curves
In this paper we study the projective normality of certain Artin-Schreier curves Y_f defined over a field F of characteristic p by the equations y^q+y=f(x), q being a power of p and f in F[x] being a polynomial in x of degree m, with (m,p)=1.
Alberto Ravagnani, Edoardo Ballico
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source

