Results 111 to 120 of about 42,945,447 (298)
Response of Monopiles Under Lateral Loading By Centrifuge Modeling
نشریه مهندسی دریا, 2016 One of the most common methods to analyze and design monopiles under lateral load is load-displacement curves, particularly the p-y curves, at different locations of the structure.
Hamid Reza Khodaei +2 more
doaj
Statistical Evaluation of API P-Y Curve Model for Offshore Piles in Cohesionless Soils
ModellingPile foundations are widely used to support offshore wind turbines. While the p-y curve method is adopted for analysis of pile–soil interactions in popular design specifications, including the American Petroleum Institute (API), its accuracy remains ...
Peiyuan Lin, Xun Yuan, Tong Liu
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Prediction of P-Y curves from finite element analyses
, 1986 The prediction of P-Y curves for undrained clay and sand based on the results of finite element analyses is presented in this thesis. A higher-ordered finite element program was used in the analyses.
She, Jairus Lai Yan
core +1 more source
Applied SciencesThis study establishes a direct and quantitative link between field-scale monopile behavior, three-dimensional finite element (FE) modeling, and practical p-y curve formulations for large-diameter offshore monopiles.
Fatma Dulger Canogullari +1 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
BuildingsThis study investigates the development of axial force in micro anti-slide piles under soil movement during slope stabilization. Axial force arises from two primary mechanisms: axial soil displacement (zs) and pile kinematics. The former plays a dominant
Guoping Lei +3 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source