Results 71 to 80 of about 717,769 (266)

Case study and practical analysis of lateral bearing characteristics of a single pile in Taihu soft soils using CPTU data

Yantu gongcheng xuebao, 2018
The muddy silty clay is rich in organic matter and widely distributed in Taihu soft soil foundation. It has a large water content and compressibility and is in a state of flow plasticity. All of these make it have bad engineering properties.
LI Hong-jiang 1,2, LIU Song-yu 1,2, TONG Li-yuan 1,2, HA Si 1,2, YANG Wan-yong 3
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

A Study on p-y Curves with Pressuremeter Tests in Jeju Basalt Rock

Journal of the Korean Geosynthetic Society, 2015
Recently, offshore wind farms are increasingly expected, because there are huge resource and large site in offshore. Jeju island has optimum condition for constructing a wind energy farm. Unlike the mainland, Jeju island has stratified structure distribution between rock layers sediments due to volcanic activation.
Ki-Ho Yang, Jong-Chul Huh, Jeong-Jun Park   +2 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Study on P-Y Curve Parameters of Large-Diameter Rock-Socketed Pile Under Lateral Load

Buildings
Response of large-diameter rock-socketed piles subjected to lateral loads is a critical issue in foundation design for bridges, high-rise buildings, and offshore platforms.
Feng Xu, Guoliang Dai, Weiming Gong, Xueying Yang, Lei Xia   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

x-y duality in topological recursion for exponential variables via quantum dilogarithm

SciPost Physics
For a given spectral curve, the theory of topological recursion generates two different families $\omega_{g,n}$ and $\omega_{g,n}^\vee$ of multi-differentials, which are for algebraic spectral curves related via the universal $x-y$ duality formula.
Alexander Hock
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source