Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52
Summary: The eradication of HIV infection is difficult to achieve because of stable viral reservoirs. Here, we show that crotonylation enhances AZD5582-induced noncanonical NF-κB (ncNF-κB) signaling, further augmenting HIV latency reversal in Jurkat and ...
Dajiang Li +10 more
doaj +1 more source
Immune Differentiation Regulator p100 Tunes NF-κB Responses to TNF
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose primary physiological function involves coordinating inflammatory and adaptive immune responses.
Budhaditya Chatterjee +11 more
doaj +1 more source
The Value of VR-PVEP in Objective Evaluation of Monocular Refractive Visual Impairment [PDF]
Objective To study the virtual reality-pattern visual evoked potential (VR-PVEP) P100 waveform characteristics of monocular visual impairment with different impaired degrees under simultaneous binocular perception and monocular stimulations.
Hong-xia HAO, Jie-min CHEN, Rong-rong WANG, Xiao-ying YU, Meng WANG, Zhi-lu ZHOU, Yan-liang SHENG, Wen-tao XIA
doaj +1 more source
SUMO1 modification of NF‐κB2/p100 is essential for stimuli‐induced p100 phosphorylation and processing [PDF]
A primary step in activating the alternative nuclear factor‐κB (NF‐κB) pathway requires NF‐κB2/p100 processing to generate p52. In most cases, stimuli‐induced p100 processing is dependent on NF‐κB‐inducing kinase/IκB kinase α‐mediated phosphorylation and ubiquitination.
Jaya, Vatsyayan +3 more
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Self-touch modulates the somatosensory evoked P100 [PDF]
It has recently been shown that contact between one's own limbs (self-touch) reduces the perceived intensity of pain, over and above the well-known modulation of pain by simultaneous colocalized tactile input Kammers et al. (Curr Biol 20:1819-1822, 2010).
Hogendoorn, H +3 more
openaire +5 more sources
Tudor-SN protein expression in colorectal cancer and its association with clinical characteristics
Tudor-SN protein (SND1) is known to be up-regulated in some types of human malignancies and functions as an oncogene. The objective of our study was to investigate the expression and prognostic value of SND1 in human colorectal cancer (CRC).
Zhu Weifang, Tan Shiyun
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NF-κB signaling and crosstalk during carcinogenesis
Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M. +2 more
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Delayed P100-Like Latencies in Multiple Sclerosis: A Preliminary Investigation Using Visual Evoked Spread Spectrum Analysis. [PDF]
Conduction along the optic nerve is often slowed in multiple sclerosis (MS). This is typically assessed by measuring the latency of the P100 component of the Visual Evoked Potential (VEP) using electroencephalography.
Hanni S M Kiiski +15 more
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HDAC5-Mediated Acetylation of p100 Suppresses Its Processing
Periodontitis is a condition involving chronic inflammation in the gums, periodontal ligaments, cementum, and alveolar bone. Nuclear factor-κB (NF-κB) activation is the prominent mediator of inflammation and osteoclast differentiation. The role of histone deacetylase 5 (HDAC5) in periodontitis development and NF-κB regulation is not fully understood.We
Jianqi Wang +5 more
openaire +3 more sources
ObjectivesMigraine is one of the most frequent clinical manifestations of hypermobile Ehlers-Danlos syndrome (hEDS). The comorbidity between these two diseases has been only partially investigated.
Ilaria Maestrini +14 more
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