Results 1 to 10 of about 94,986 (161)

PI3 kinase signaling pathway in hematopoietic cancers: A glance in miRNA's role. [PDF]

J Clin Lab Anal, 2021
PI3K pathway involves in a wide verity of important biological events in cells such as proliferation, differentiation, apoptosis, and even drug resistance. It is confirmed that there is a relationship between dysregulation of mediators involved in this signaling pathway and different cancer types such as hematopoietic malignancies.
Roshandel E, Noorazar L, Farhadihosseinabadi B, Mehdizadeh M, Kazemi MH, Parkhideh S.   +5 more
europepmc   +2 more sources

Immunomodulatory Mechanisms of Rehmanniae Radix Praeparata-Achyranthes Root-Chinese Angelica Root Combination in Nontraumatic Osteonecrosis of the Femoral Head: A Comprehensive Network Pharmacology and Molecular Docking Study Focusing on Immunological Pathways. [PDF]

Mediators Inflamm
Objective Nontraumatic osteonecrosis of the femoral head (NONFH) is a devastating condition characterised by immune dysregulation and sterile inflammation, which are increasingly acknowledged as central pathogenic mechanisms. This study aims to identify the core herbal combination for NONFH and systematically explore its immunomodulatory effects and ...
Li X, Ng L, Liu C, Qin L, Xiao P, Liu C, Liu Y, Zhang Q, Huang W, Zhou Y, Liu W.   +10 more
europepmc   +2 more sources

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment. [PDF]

MedComm (2020)
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Jiang M, Zhang K, Zhang Z, Zeng X, Huang Z, Qin P, Xie Z, Cai X, Ashrafizadeh M, Tian Y, Wei R.   +10 more
europepmc   +2 more sources

Lactiplantibacillus plantarum P101 Attenuated Cyclophosphamide-Induced Liver Injury in Mice by Regulating the Nrf2/ARE Signaling Pathway

International Journal of Molecular Sciences, 2023
Cyclophosphamide causes side effects in cancer patients, including hepatotoxicity. Probiotics have recently emerged as potential approaches for the administration of many diseases.
T. You, Yu Zhao, Shanji Liu, Hengyi Xu
semanticscholar   +1 more source

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Cell Reports, 2023
Summary Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two distinct complexes (p110γ-p84 and p110γ-p101), which are differentially activated by G protein-coupled receptors (GPCRs) and Ras.
M. Rathinaswamy, M. Jenkins, Benjamin R. Duewell, Xuxiao Zhang, N. J. Harris, John T. Evans, Jordan T B Stariha, U. Dalwadi, Kaelin D. Fleming, Harish Ranga-prasad, C. Yip, Roger L. Williams, Scott D. Hansen, J. Burke   +13 more
semanticscholar   +1 more source

LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via regulating the Wnt/β-catenin pathway

Autoimmunity, 2023
LncRNA OIP5-AS1 has a common gene imbalance in various cancers and tumours, which plays an important role in regulating its biological function. However, there are few studies on lncRNA OIP5-AS1 in rheumatoid arthritis (RA).
Yuan‐Bo Sun, Hui Jiang, Lingyu Pan, Yanquan Han, Yan Chen, Yeke Jiang, Yongzhong Wang   +6 more
semanticscholar   +1 more source

The Molecular Mechanism of the TEAD1 Gene and miR-410-5p Affect Embryonic Skeletal Muscle Development: A miRNA-Mediated ceRNA Network Analysis

Cells, 2023
Muscle development is a complex biological process involving an intricate network of multiple factor interactions. Through the analysis of transcriptome data and molecular biology confirmation, this study aims to reveal the molecular mechanism underlying
Wenping Hu, Xinyue Wang, Yazhen Bi, J. Bao, Mingyu Shang, Li Zhang   +5 more
semanticscholar   +1 more source

Le pouvoir impérial et les religions dans l’Empire (284-410)

Gouverner un empire de 284 à 410 apr. J.-C., 2023
Pour comprendre les relations complexes entre le pouvoir impérial et les religions entre 284 et 410, il convient d’abord d’évoquer la définition religieuse de l’autorité impériale.
Christophe J. Goddard
semanticscholar   +1 more source

Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation

Science Advances, 2021
The structure of class IB PI3K (p110γ-p101) reveals mechanism of GPCR activation and differences from class IA PI3Ks.
M. Rathinaswamy, U. Dalwadi, Kaelin D. Fleming, Carson Adams, Jordan T B Stariha, E. Pardon, M. Baek, O. Vadas, F. DiMaio, J. Steyaert, Scott D. Hansen, C. Yip, J. Burke   +12 more
semanticscholar   +1 more source

Lactiplantibacillus plantarum P101 alleviates alcoholic liver injury by modulating the Nrf2/HO-1 pathway in mice.

Journal of Applied Microbiology, 2022
AIMS The occurrence of alcoholic liver injury is related to the oxidative stress. Bacteria for alleviating alcoholic related liver injury have received widespread attention.
Shanji Liu, Yu Zhao, Xiaowei Xu, Mengqi Wang, X. Tao, Hengyi Xu   +5 more
semanticscholar   +1 more source