Results 141 to 150 of about 308,059 (252)

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

open access: yesAdvanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li   +11 more
wiley   +1 more source

Neurología general P3 (Pósteres)

open access: yesNeurology Perspectives, 2023
doaj   +1 more source

Passive Metasurface Tweezers for Multi‐Scale Orbital Transport and Trapping on Elastic Plates

open access: yesAdvanced Science, EarlyView.
Passive labyrinthine phase encoding converts single‐channel excitation into localized flexural‐wave vortices with programmable orbital angular momentum. The resulting vortex fields enable cross‐scale particle manipulation, including orbital transport, central confinement, and rotational actuation.
Zeyang Bi   +7 more
wiley   +1 more source

Mixed‐Valence Atomic‐Layer Iridium Patches Enhance Alkaline Hydrogen Evolution

open access: yesAdvanced Science, EarlyView.
Engineering iridium architectures on Cu3P nanowires reveals that atomic‐layer Ir patches form a mixed‐valence interfacial motif with an anisotropic electronic structure. This configuration balances water dissociation and hydrogen adsorption/desorption, delivering superior alkaline hydrogen evolution with a 27 mV overpotential and 1 A cm−2 operation in ...
Payam Ahmadian Koudakan   +7 more
wiley   +1 more source

Distinct Neural Modes Carry Information About Attempted Grasp Timing and Force in the Sensorimotor Cortex. [PDF]

open access: yesJ Neurosci
Blumenthal GH   +12 more
europepmc   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

open access: yesAdvanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen   +11 more
wiley   +1 more source

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