Results 1 to 10 of about 37,116 (209)

The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP [PDF]

Nucleic Acids Research, 2007
When an essential amino acid is limited, a signaling cascade is triggered that leads to increased translation of the 'master regulator', activating transcription factor 4 (ATF4), and resulting in the induction of specific target genes. Binding of ATF4 to the amino acid response element (AARE) is an essential step in the transcriptional activation of ...
Cherasse, Yoan, Maurin, Anne-Catherine, Chaveroux, Cédric, Jousse, Céline, Carraro, Valerie, Parry, Laurent, Deval, Christiane, Chambon, Christophe, Fafournoux, Pierre, Bruhat, Alain   +9 more
openaire   +5 more sources

P300/CBP‐associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation [PDF]

The FASEB Journal, 2018
ABSTRACT The epigenetic enzyme p300/CBP‐associated factor (PCAF) belongs to the GCN5‐related N ‐acetyltransferase (GNAT) family together with GCN5. Although its transcriptional and post‐translational function is well characterized, little is known about its properties as ...
Savoia, Matteo, Cencioni, Chiara, Mori, Mattia, Atlante, Sandra, Zaccagnini, Germana, Devanna, Paolo, Di Marcotullio, Lucia, Botta, Bruno, Martelli, Fabio, Zeiher, Andreas M, Pontecorvi, Alfredo, Farsetti, Antonella, Spallotta, Francesco, Gaetano, Carlo   +13 more
openaire   +9 more sources

miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells [PDF]

BMC Cancer, 2012
Abstract Background Androgen receptor (AR) signalling is critical to the initiation and progression of prostate cancer (PCa). Transcriptional activity of AR involves chromatin recruitment of co-activators, including the p300/CBP-associated factor (PCAF).
Gong Ai-Yu, Eischeid Alex N, Xiao Jing, Zhao Jian, Chen Dongqing, Wang Zhao-Yi, Young Charles YF, Chen Xian-Ming   +7 more
openaire   +5 more sources

The Nuclear Receptor Coactivators p300/CBP/Cointegrator-Associated Protein (p/CIP) and Transcription Intermediary Factor 2 (TIF2) Differentially Regulate PKA-Stimulated Transcriptional Activity of Steroidogenic Factor 1 [PDF]

Molecular Endocrinology, 2002
Steroidogenic factor-1 (SF-1) is a member of the nuclear receptor superfamily that plays essential roles in the development of endocrine organs. Steroid receptor coactivator 1 and transcription intermediary factor 2 (TIF2) belong to the p160 coactivator family that mediates transcriptional activation by several nuclear receptors, including SF-1.
Bente, Børud, Tuyen, Hoang, Marit, Bakke, Anne L, Jacob, Johan, Lund, Gunnar, Mellgren   +5 more
  +6 more sources

The MSG1 Non-DNA-binding Transactivator Binds to the p300/CBP Coactivators, Enhancing Their Functional Link to the Smad Transcription Factors [PDF]

Journal of Biological Chemistry, 2000
The MSG1 nuclear protein has a strong transcriptional activating activity but does not bind directly to DNA. When cotransfected, MSG1 enhances transcription mediated by the Smad transcription factors in mammalian cells in a manner dependent on ligand-induced Smad hetero-oligomerization. However, the mechanism of this MSG1 effect has been unknown.
T, Yahata, M P, de Caestecker, R J, Lechleider, S, Andriole, A B, Roberts, K J, Isselbacher, T, Shioda   +6 more
openaire   +4 more sources

The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression [PDF]

Nucleic Acids Research, 2011
HBP1 is a sequence-specific DNA-binding transcription factor with many important biological roles. It activates or represses the expression of some specific genes during cell growth and differentiation. Previous studies have exhibited that HBP1 binds to p16(INK4A) promoter and activates p16(INK4A) expression.
Wang, Weibin, Pan, Kewu, Chen, Yifan, Huang, Chunyin, Zhang, Xiaowei   +4 more
openaire   +3 more sources

Transcriptional Coactivator p300/CBP-Associated Factor and p300/CBP-Associated Factor Type B Are Required for Normal Estrogen Response of the Mouse Uterus [PDF]

Bioscience, Biotechnology, and Biochemistry, 2004
Mice with targeted gene disruption of one of the estrogen receptor coactivators, p300/CBP-associated factor (PCAF), and its counterpart, PCAF-B, were used to investigate the possible involvement of PCAF and PCAF-B in estrogen receptor-mediated actions in vivo.
Erina, Inoue, Miho, Hanai, Kazuhiko, Yamada, Takatoshi, Esashi, Jun, Yamauchi   +4 more
openaire   +4 more sources

Interferon Regulatory Factor-7 Synergizes with Other Transcription Factors through Multiple Interactions with p300/CBP Coactivators [PDF]

Journal of Biological Chemistry, 2003
Interferon regulatory factor (IRF)-7 is activated in response to virus infection and stimulates the transcription of a set of cellular genes involved in host antiviral defense. The mechanism by which IRF-7 is activated and cooperates with other transcription factors is not fully elucidated.
Hongmei, Yang, Charles H, Lin, Gang, Ma, Michael O, Baffi, Marc G, Wathelet   +4 more
openaire   +4 more sources

An Interaction between the Human T Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) and the KIX Domain of p300/CBP Contributes to the Down-regulation of Tax-dependent Viral Transcription by HBZ [PDF]

Journal of Biological Chemistry, 2008
Activation of human T cell leukemia virus type 1 (HTLV-1) transcription is established through the formation of protein complexes on the viral promoter that are essentially composed of the cellular basic leucine zipper (bZIP) transcription factor cAMP-response element-binding protein (CREB (or certain other members of the ATF/CREB family), the HTLV-1 ...
Clerc, Isabelle, Polakowski, Nicholas, André-Arpin, Charlotte, Cook, Pamela, Barbeau, Benoit, Mesnard, Jean-Michel, Lemasson, Isabelle   +6 more
openaire   +3 more sources

CBP/p300, a promising therapeutic target for prostate cancer [PDF]

Journal of Translational Medicine
Prostate cancer (PCa) remains the most prevalent malignancy among men, with the inevitable emergence of castration-resistant prostate cancer (CRPC) presenting the greatest challenge.
Hongtao Xu, Yifan Hou, Zhenhua Zhao, Jianhua Zhang, Pan Li, Yujia Cao, Xiaobo Nie, Junqing Hou   +7 more
doaj   +2 more sources