Results 91 to 100 of about 37,116 (209)

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, EarlyView.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source

The glucocorticoid receptor in inflammatory processes : transrepression is not enough [PDF]

, 2015
Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by
Dejager, Lien, Hübner, Sabine, Libert, Claude, Tuckermann, Jan P   +3 more
core   +2 more sources

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis

Frontiers in Plant Science, 2017
Arabidopsis has 12 histone acetyltransferases grouped in four families: the GNAT/HAG, the MYST/HAM, the p300/CBP/HAC and the TAFII250/HAF families. We previously showed that ham1 and ham2 mutants accumulated higher damaged DNA after UV-B exposure than WT
Julieta P. Fina, Fiorella Masotti, Sebastián P. Rius, Franco Crevacuore, Paula Casati   +4 more
doaj   +1 more source

Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette, Chloé Ilbert, Sébastien Aimé, Hoai‐Nam Truong, Marielle Adrian, Stéphane Bourque   +5 more
wiley   +1 more source

Alcohol-Induced Histone Acetylation Reveals a Gene Network Involved in Alcohol Tolerance [PDF]

, 2013
Alfredo Ghezzi, Harish R. Krishnan, Linda Lew, Francisco J. Prado III, Darryl S. Ong, Nigel S. Atkinson, Section of Neurobiology and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of ...
Atkinson, Nigel S., Ghezzi, Alfredo, Krishnan, Harish R., Lew, Linda, Ong, Darryl S., Prado III, Francisco J.   +5 more
core   +3 more sources

Functional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesis

Frontiers in Microbiology, 2013
The production of antisense transcripts from the 3’ long terminal repeat (LTR) in human T-lymphotropic retroviruses has now been clearly demonstrated. After the identification of the antisense strand-encoded HTLV-1 bZIP (HBZ) factor, we reported that HBZ
Benoit eBarbeau, Jean-Marie ePeloponese, Jean-Michel eMesnard   +2 more
doaj   +1 more source

Leprosy drug clofazimine activates peroxisome proliferator-activated receptor-γ and synergizes with imatinib to inhibit chronic myeloid leukemia cells

Haematologica, 2020
Leukemia stem cells contribute to drug-resistance and relapse in chronic myeloid leukemia (CML) and BCR-ABL1 inhibitor monotherapy fails to eliminate these cells, thereby necessitating alternate therapeutic strategies for patients CML.
Harish Kumar, Sourav Chattopadhyay, Nabanita Das, Sonal Shree, Dinesh Patel, Jogeswar Mohapatra, Anagha Gurjar, Sapana Kushwaha, Abhishek Kumar Singh, Shikha Dubey, Kiran Lata, Rajesh Kushwaha, Riyazuddin Mohammed, Krishnarup Ghosh Dastidar, Namrata Yadav, Achchhe Lal Vishwakarma, Jiaur Rahaman Gayen, Sanghamitra Bandyopadhyay, Abhijit Chatterjee, Mukul Rameshchandra Jain, Anil Kumar Tripathi, Arun Kumar Trivedi, Naibedya Chattopadhyay, Ravishankar Ramachandran, Sabyasachi Sanyal   +24 more
doaj   +1 more source

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family. [PDF]

, 2019
E2F transcription factors are central regulators of cell division and cell fate decisions. E2F4 often represents the predominant E2F activity in cells.
Arand, Julia, Brison, Caileen M, Chaikovsky, Andrea, Demeter, Janos, Hsu, Jenny, Jackson, Peter K, Mooney, Nancie A, Oliverio, Romane, Rubin, Seth M, Sage, Julien, Vogel, Hannes   +10 more
core