Results 101 to 110 of about 37,116 (209)

Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis [PDF]

, 2015
Induced pluripotent stem (iPS) cells can be generated from somatic cells by coexpression of four transcription factors: Sox2, Oct4, Klf4, and c-Myc.
Dai, Xiangpeng, Inuzuka, Hiroyuki, Lau, Alan W, Liu, Pengda, Liu, Yueyong   +4 more
core   +1 more source

High-density P300 enhancers control cell state transitions. [PDF]

, 2015
BACKGROUND: Transcriptional enhancers are frequently bound by a set of transcription factors that collaborate to activate lineage-specific gene expression. Recently, it was appreciated that a subset of enhancers comprise extended clusters dubbed stretch-
Bradley, Allan, Enright, Anton J, Muljo, Stefan A, Witte, Steven   +3 more
core   +1 more source

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

PLoS Biology, 2012
Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this is strictly due to repression of proliferation remains a subject of debate.
Abhinav K Jain, Kendra Allton, Michelina Iacovino, Elisabeth Mahen, Robert J Milczarek, Thomas P Zwaka, Michael Kyba, Michelle Craig Barton   +7 more
doaj   +1 more source

T‐cell exhaustion from a multiomics perspective: Differentiation mechanisms and regulatory networks in the journey from progenitor‐Exhausted T cells to terminally exhausted T cells

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
(1) Core Process: Persistent antigen, from TDLNs to TME, drives Tpex → Tex‐int → Tex‐term differentiation. (2) Multiomics Regulation: This fate transition is orchestrated by a co‐ordinated, multi‐layered molecular network. (3) Functional Outcome: Dysregulated signalling and surging co‐inhibitory receptors lock in proliferative arrest and functional ...
Tong Zhu, Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Yunshan Wang, Maoxiao Feng   +5 more
wiley   +1 more source

Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor [PDF]

, 2022
Alexandra D. Brown, Kathleen L. Vergunst, Makenzie Branch, Connor M. Blair, Denis J. Dupré, George S. Baillie, David N. Langelaan   +6 more
openalex   +1 more source

RNA Binding to CBP Stimulates Histone Acetylation and Transcription [PDF]

, 2017
CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-regulatory elements that control patterns of gene expression in multicellular organisms. Active enhancers produce bi-directional enhancer RNAs (eRNAs) and display CBP/
Bailey, Barlev, Bedford, Beltran, Berndsen, Bezzi, Bonasio, Bowers, Castello, Cifuentes-Rojas, Corcoran, Creyghton, Daniel A. Bose, Danny Reinberg, Davidovich, De Santa, Delvecchio, Di Ruscio, Friedersdorf, Greg Donahue, Gupta, Hafner, Hah, He, Heinz, Hendrickson, Henry, Hilton, Hsieh, Huang, Huppertz, Jin, Kagey, Kaikkonen, Kaneko, Kaneko, Kaneko, Kasper, Kim, Kim, Lai, Lam, Lam, Langmead, Li, Li, Lienert, Liu, Lowary, Luger, Martin, Matys, May, Melo, Meng, Mousavi, Peterson, Pnueli, Postepska-Igielska, Quinlan, Rada-Iglesias, Ramin Shiekhattar, Roberto Bonasio, Schaukowitch, Schröder, Shelley L. Berger, Shen, Stasevich, Sun, Tanaka, Thompson, Thompson, Tie, Wang, Wang, Wang, Wang, Wang, Wongtrakoongate, Yang, Yue, Zhang, Ørom   +82 more
core   +1 more source

Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF).

The Journal of biological chemistry, 2000
Transcription factors of the ONECUT class, whose prototype is HNF-6, contain a single cut domain and a divergent homeodomain characterized by a phenylalanine at position 48 and a methionine at position 50. The cut domain is required for DNA binding. The homeodomain is required either for DNA binding or for transcriptional stimulation, depending on the ...
V J, Lannoy, A, Rodolosse, C E, Pierreux, G G, Rousseau, F P, Lemaigre   +4 more
openaire   +1 more source

NF‐κB Is a Potential Therapeutic Target for Histone Deacetylase Inhibitor‐Resistant Cutaneous T‐Cell Lymphoma

Cancer Science, Volume 117, Issue 2, Page 407-417, February 2026.
We identified a novel mechanism of resistance to histone deacetylase inhibitors (HDACi) in cutaneous T‐cell lymphoma (CTCL), mediated by NF‐κB activation. This finding highlights NF‐κB as a potential therapeutic target for overcoming HDACi resistance in CTCL.
Yuto Takahashi, Akihiro Kitadate, Sayaka Iwama, Wataru Kuroki, Ko Abe, Masahiro Yamada, Sho Ikeda, Hiroyuki Tagawa, Hideki Wakui, Masaki Hikida, Naoto Takahashi   +10 more
wiley   +1 more source

The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity

Cell Reports
Summary: The Ada two A-containing (ATAC) complex, containing histone acetyltransferases general control non-derepressible 5 (GCN5) or p300/CBP-associated factor (PCAF), has gained recognition as a prominent transcriptional coactivator. Recent revelations
Xiaolu Wang, Lingling Wang, Zhili Zhou, Chenhao Jiang, Ziyu Bao, Yuexin Wang, Ying Zhang, Lili Song, Yueling Zhao, Xinying Li, Qianqian Li, Yujun Shen, Ying Yu, Wenyi Mi   +13 more
doaj   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, Volume 158, Issue 2, Page 314-332, 15 January 2026.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source